Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.

设计、合成经典和非经典 2-氨基-4-氧代-5-取代-6-乙基噻吩并[2,3-d]嘧啶类化合物，并研究其作为双重胸苷酸合成酶和二氢叶酸还原酶抑制剂及潜在抗肿瘤药物的 X 射线晶体结构