日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation.

蛋白质脱乙酰酶 SIRT2 对适应性 β 细胞增殖发挥代谢控制作用。

Wortham Matthew, Ramms Bastian, Zeng Chun, Benthuysen Jacqueline R, Sai Somesh, Pollow Dennis P, Liu Fenfen, Schlichting Michael, Harrington Austin R, Liu Bradley, Prakash Thazha P, Pirie Elaine C, Zhu Han, Baghdasarian Siyouneh, Lee Sean T, Ruthig Victor A, Wells Kristen L, Auwerx Johan, Shirihai Orian S, Sander Maike

S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.

S-亚硝基化的TDP-43可引发hiPSCs和ALS/FTD体内模型中的聚集、细胞间传播和神经毒性

Pirie Elaine, Oh Chang-Ki, Zhang Xu, Han Xuemei, Cieplak Piotr, Scott Henry R, Deal Amanda K, Ghatak Swagata, Martinez Fernando J, Yeo Gene W, Yates John R 3rd, Nakamura Tomohiro, Lipton Stuart A

Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2'-O-Methoxyethyl Antisense Oligonucleotide

杂交小鼠多样性分析鉴定出与2'-O-甲氧基乙基反义寡核苷酸介导的急性炎症反应相关的遗传结构

Pirie, Elaine; Cauntay, Patrick; Fu, Wuxia; Ray, Shayoni; Pan, Calvin; Lusis, Aldonis J; Hsiao, Jill; Burel, Sebastien A; Narayanan, Padma; Crooke, Rosanne M; Lee, Richard G

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

异常的蛋白质S-亚硝基化与神经退行性疾病的病理生理学有关。

Nakamura, Tomohiro; Prikhodko, Olga A; Pirie, Elaine; Nagar, Saumya; Akhtar, Mohd Waseem; Oh, Chang-Ki; McKercher, Scott R; Ambasudhan, Rajesh; Okamoto, Shu-ichi; Lipton, Stuart A

Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept

顺铂治疗小鼠持续性痛觉过敏(通过阈值测定、条件性位置偏好范式和背根神经节激活转录因子3的变化来定义):加巴喷丁、酮咯酸和依那西普的作用

Park, Hue Jung; Stokes, Jennifer A; Pirie, Elaine; Skahen, James; Shtaerman, Yuri; Yaksh, Tony L

A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.

Ikbkg 的突变会导致免疫缺陷,但不会损害 IkappaB α 的降解

Siggs Owen M, Berger Michael, Krebs Philippe, Arnold Carrie N, Eidenschenk Celine, Huber Christoph, Pirie Elaine, Smart Nora G, Khovananth Kevin, Xia Yu, McInerney Gerald, Karlsson Hedestam Gunilla B, Nemazee David, Beutler Bruce