日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety and Tolerability of a Novel Anti-HER2 Antibody-Drug Conjugate (PF-06804103) in Patients with HER2-Expressing Solid Tumors: A Phase 1 Dose-Escalation Study

新型抗HER2抗体药物偶联物(PF-06804103)在HER2表达实体瘤患者中的安全性和耐受性:一项I期剂量递增研究

Meric-Bernstam, Funda; Calvo, Emiliano; Lee, Keun Seok; Moreno, Victor; Park, Yeon Hee; Rha, Sun Young; Chalasani, Pavani; Zhong, Wei; Zhou, Li; Pirie-Shepherd, Steven; Leung, Abraham C F; Curigliano, Giuseppe

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

NOTCH3 靶向抗体药物偶联物通过诱导受体细胞凋亡和通过内吞作用进入配体细胞来消退肿瘤

Kenneth G Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christophe

Pixelwise H-score: A novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images

像素级H评分:一种基于数字图像分析的新型指标,用于量化免疫组织化学图像中的膜生物标志物表达。

Ram, Sripad; Vizcarra, Pamela; Whalen, Pamela; Deng, Shibing; Painter, C L; Jackson-Fisher, Amy; Pirie-Shepherd, Steven; Xia, Xiaoling; Powell, Eric L

First-in-human, phase I study of PF-06647263, an anti-EFNA4 calicheamicin antibody-drug conjugate, in patients with advanced solid tumors

PF-06647263(一种抗EFNA4卡利奇霉素抗体药物偶联物)在晚期实体瘤患者中的首次人体I期研究

Garrido-Laguna, Ignacio; Krop, Ian; Burris, Howard A 3rd; Hamilton, Erika; Braiteh, Fadi; Weise, Amy M; Abu-Khalaf, Maysa; Werner, Theresa L; Pirie-Shepherd, Steven; Zopf, Christopher J; Lakshminarayanan, Mani; Holland, Jaymes S; Baffa, Raffaele; Hong, David S

Detecting expression of 5T4 in CTCs and tumor samples from NSCLC patients

检测 NSCLC 患者 CTC 和肿瘤样本中 5T4 的表达

Steven R Pirie-Shepherd, Cory Painter, Pamela Whalen, Pamela Vizcarra, Marc Roy, Jesse Qian, Tania Franks, Tim Coskran, Jon Golas, Shibing Deng, Wenyan Zhong, Eric Tucker, Dena Marrinucci, Hans-Peter Gerber, Eric L Powell

Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers

血管生成素 2 和 VEGF 通路联合治疗早期乳腺癌、结直肠癌和肾癌术后辅助治疗的疗效

Florence T H Wu, Shan Man, Ping Xu, Annabelle Chow, Marta Paez-Ribes, Christina R Lee, Steven R Pirie-Shepherd, Urban Emmenegger, Robert S Kerbel

The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs

分子量、PK 和效价对抗体药物肿瘤生物分布和疗效的影响

Ruth Muchekehu, Dingguo Liu, Mark Horn, Lioudmila Campbell, Joselyn Del Rosario, Michael Bacica, Haim Moskowitz, Trina Osothprarop, Anouk Dirksen, Venkata Doppalapudi, Allan Kaspar, Steven R Pirie-Shepherd, Julia Coronella

Antitumor efficacy of a thrombospondin 1 mimetic CovX-body

血小板反应蛋白 1 模拟物 CovX-body 的抗肿瘤功效

Lingna Li, Tom A Leedom, Janet Do, Hanhua Huang, JingYu Lai, Kim Johnson, Trina F Osothprarop, John D Rizzo, Venkata R Doppalapudi, Curt W Bradshaw, Rodney W Lappe, Gary Woodnutt, Nancy J Levin, Steven R Pirie-Shepherd

Vitamin D binding protein-macrophage activating factor directly inhibits proliferation, migration, and uPAR expression of prostate cancer cells.

维生素 D 结合蛋白-巨噬细胞激活因子直接抑制前列腺癌细胞的增殖、迁移和 uPAR 表达

Gregory Kalvin J, Zhao Bing, Bielenberg Diane R, Dridi Sami, Wu Jason, Jiang Weihua, Huang Bin, Pirie-Shepherd Steven, Fannon Michael