日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Photolabile oligonucleotides combined with topologically imposed light gradients enable spatially resolved single-cell transcriptomics and epigenomics

光敏寡核苷酸与拓扑施加的光梯度相结合,可实现空间分辨的单细胞转录组学和表观基因组学研究。

Piscopio, Robert A; Chialastri, Alex; Wang, Chieh; Godzik, Mikolaj; Heom, Kellie A; Wang, Weiyue; Wilson, Maxwell Z; Dey, Siddharth S

Optogenetic Rescue Reveals Spatiotemporal Rules of Germ-Layer Patterning

光遗传学拯救揭示胚层模式形成的时空规律

Baxter, Naomi; Piscopio, Robert; Rufo, Joseph; Han, Dasol; Whitehead, Isobel; Dhillon, Jasmine; Dey, Siddharth S; Wilson, Maxwell Z

Cleavage of protein kinase c δ by caspase-3 mediates proinflammatory cytokine-induced apoptosis in pancreatic islets

胱天蛋白酶-3 切割蛋白激酶 cδ 介导促炎性细胞因子诱导的胰岛细胞凋亡

Jillian Collins, Robert A Piscopio, Mary E Reyland, Chelsea G Johansen, Richard K P Benninger, Nikki L Farnsworth

Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy

阐明新型 HDAC 抑制剂 bocodepsin (OKI-179) 对 T 细胞的直接影响,以合理设计与免疫疗法相结合的方案

Nisha Holay, Alexander Somma, Mark Duchow, Milad Soleimani, Anna Capasso, Srividya Kottapalli, Joshua Rios, Uma Giri, Jennifer Diamond, Anna Schreiber, Anthony D Piscopio, Carla Van Den Berg, S Gail Eckhardt, Todd A Triplett

First-in-Human Dose-Escalation Study of the Novel Oral Depsipeptide Class I-Targeting HDAC Inhibitor Bocodepsin (OKI-179) in Patients with Advanced Solid Tumors

新型口服去肽类 I 类靶向 HDAC 抑制剂 Bocodepsin (OKI-179) 在晚期实体瘤患者中的首次人体剂量递增研究

Schreiber, Anna R; Kagihara, Jodi A; Corr, Bradley R; Davis, S Lindsey; Lieu, Christopher; Kim, Sunnie S; Jimeno, Antonio; Camidge, D Ross; Williams, Jud; Heim, Amy M; Martin, Anne; DeMattei, John A; Holay, Nisha; Triplett, Todd A; Eckhardt, S Gail; Litwiler, Kevin; Winkler, James; Piscopio, Anthony D; Diamond, Jennifer R

Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response

胰岛的功能结构揭示了驱动第一阶段钙反应的第一反应细胞群。

Kravets, Vira; Dwulet, JaeAnn M; Schleicher, Wolfgang E; Hodson, David J; Davis, Anna M; Pyle, Laura; Piscopio, Robert A; Sticco-Ivins, Maura; Benninger, Richard K P

Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

用于治疗实体瘤的I类选择性组蛋白去乙酰化酶抑制剂OKI-179的临床前开发

Diamond, Jennifer R; Pitts, Todd M; Ungermannova, Dana; Nasveschuk, Christopher G; Zhang, Gan; Phillips, Andrew J; Bagby, Stacey M; Pafford, Jessica; Yacob, Betelehem W; Newton, Timothy P; Tentler, John J; Gittleman, Brian; Hartman, Sarah J; DeMattei, John A; Winkler, James D; Wendt, Michael K; Schiemann, William P; Eckhardt, S Gail; Liu, Xuedong; Piscopio, Anthony D

Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes

型糖尿病发展过程中胰岛内间隙连接偶联的调节

Nikki L Farnsworth, Robert A Piscopio, Wolfgang E Schleicher, David G Ramirez, Jose G Miranda, Richard K P Benninger

Optogenetic stimulation of cholinergic fibers for the modulation of insulin and glycemia

利用光遗传学刺激胆碱能纤维来调节胰岛素和血糖

Fontaine, Arjun K; Ramirez, David G; Littich, Samuel F; Piscopio, Robert A; Kravets, Vira; Schleicher, Wolfgang E; Mizoguchi, Naoko; Caldwell, John H; Weir, Richard F Ff; Benninger, Richard K P

Caloric restriction recovers impaired β-cell-β-cell gap junction coupling, calcium oscillation coordination, and insulin secretion in prediabetic mice

热量限制可恢复糖尿病前期小鼠受损的β细胞-β细胞间隙连接、钙振荡协调和胰岛素分泌。

Corezola do Amaral, Maria Esméria; Kravets, Vira; Dwulet, JaeAnn M; Farnsworth, Nikki L; Piscopio, Robert; Schleicher, Wolfgang E; Miranda, Jose Guadalupe; Benninger, Richard K P