日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An Aptamer-Based EXACT Anticoagulant as a Sustainable, Animal-Free Alternative to Unfractionated Heparin

一种基于适配体的EXACT抗凝剂,可作为普通肝素的可持续、无动物成分替代品。

Yu, Haixiang; Pitoc, George; Zhang, Manqi; Clancy, Jeffrey; Frederiksen, James; Yan, Amy; Francis, Samuel; Sullenger, Rebecca; Rempel, Rachel; Gammell, Susannah; Caiazzi, Jillian; Sullenger, Bruce A

Association of Retinal Oximetry with Peripheral Diabetic Retinopathy Lesions and Nonperfusion on Ultra-widefield Angiography

视网膜氧饱和度与周围糖尿病视网膜病变及超广角血管造影无灌注的相关性

Sampani, Konstantina; Ashraf, Mohamed; Pitoc, Cloyd M; Rhee, Jae; Tolson, Ann M; Cavallerano, Jerry D; Sun, Jennifer K; Aiello, Lloyd Paul; Silva, Paolo S

Rats subject to extracorporeal membrane oxygenation have improved cardiac function following anticoagulation and reversal with factor IXa aptamer-antidote oligonucleotide pair

接受体外膜肺氧合(ECMO)治疗的大鼠,在抗凝治疗和使用 IXa 因子适体-解毒寡核苷酸对逆转抗凝作用后,心脏功能得到改善。

Nimjee, Shahid M; de Lange, Fellery; Pitoc, George A; Sullenger, Bruce A

Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors

适体水蛭素作为选择性和可逆的EXO位点-活性位点(EXACT)抑制剂

Yu, Haixiang; Kumar, Shekhar; Frederiksen, James W; Kolyadko, Vladimir N; Pitoc, George; Layzer, Juliana; Yan, Amy; Rempel, Rachel; Francis, Samuel; Krishnaswamy, Sriram; Sullenger, Bruce A

Retinal Vascular Caliber Association with Nonperfusion and Diabetic Retinopathy Severity Depends on Vascular Caliber Measurement Location

视网膜血管直径与无灌注和糖尿病视网膜病变严重程度的关联取决于血管直径的测量位置。

Ashraf, Mohamed; Shokrollahi, Siamak; Pisig, Alex U; Sampani, Konstantina; Abdelal, Omar; Cavallerano, Jerry D; Robertson, Gavin; Fleming, Alan; van Hemert, Jano; Pitoc, Cloyd M; Sun, Jennifer K; Aiello, Lloyd Paul; Silva, Paolo S

Comparison of SDOCT Scan Types for Grading Disorganization of Retinal Inner Layers and Other Morphologic Features of Diabetic Macular Edema

比较不同SDOCT扫描类型对糖尿病性黄斑水肿视网膜内层结构紊乱及其他形态学特征的分级效果

Sampani, Konstantina; Abdulaal, Marwan; Peiris, Timothy; Lin, Michael M; Pitoc, Cloyd; Ledesma, Migil; Lammer, Jan; Silva, Paolo S; Aiello, Lloyd Paul; Sun, Jennifer K

Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers

抗 PEG 抗体抑制聚乙二醇化适体的抗凝活性

Angelo Moreno, George A Pitoc, Nancy J Ganson, Juliana M Layzer, Michael S Hershfield, Alice F Tarantal, Bruce A Sullenger

Probing the coagulation pathway with aptamers identifies combinations that synergistically inhibit blood clot formation

利用适体探测凝血途径,可以鉴定出能够协同抑制血栓形成的适体组合。

Bompiani, Kristin M; Lohrmann, Jens L; Pitoc, George A; Frederiksen, James W; Mackensen, George B; Sullenger, Bruce A

Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses

核酸清除聚合物抑制细胞外 DNA 介导的先天免疫激活,而不会抑制抗病毒反应

Eda K Holl, Kara L Shumansky, George Pitoc, Elizabeth Ramsburg, Bruce A Sullenger

Nucleic acid scavengers inhibit thrombosis without increasing bleeding

核酸清除剂可抑制血栓形成,且不会增加出血风险。

Jain, Shashank; Pitoc, George A; Holl, Eda K; Zhang, Ying; Borst, Luke; Leong, Kam W; Lee, Jaewoo; Sullenger, Bruce A