日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

降低朊病毒蛋白水平是一种能够改善朊病毒疾病各个阶段、毒株和终点的疾病治疗手段。

Minikel, Eric Vallabh; Zhao, Hien T; Le, Jason; O'Moore, Jill; Pitstick, Rose; Graffam, Samantha; Carlson, George A; Kavanaugh, Michael P; Kriz, Jasna; Kim, Jae Beom; Ma, Jiyan; Wille, Holger; Aiken, Judd; McKenzie, Deborah; Doh-Ura, Katsumi; Beck, Matthew; O'Keefe, Rhonda; Stathopoulos, Jacquelyn; Caron, Tyler; Schreiber, Stuart L; Carroll, Jeffrey B; Kordasiewicz, Holly B; Cabin, Deborah E; Vallabh, Sonia M

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

在β-淀粉样蛋白存在的情况下,tau蛋白的减少可以预防体内tau蛋白病理和神经元死亡。

DeVos, Sarah L; Corjuc, Bianca T; Commins, Caitlin; Dujardin, Simon; Bannon, Riley N; Corjuc, Diana; Moore, Benjamin D; Bennett, Rachel E; Jorfi, Mehdi; Gonzales, Jose A; Dooley, Patrick M; Roe, Allyson D; Pitstick, Rose; Irimia, Daniel; Frosch, Matthew P; Carlson, George A; Hyman, Bradley T

Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

在肾痨模型中,通过药物或基因手段抑制 CDK5 来缩短纤毛长度可减轻多囊肾病。

Husson, Hervé; Moreno, Sarah; Smith, Laurie A; Smith, Mandy M; Russo, Ryan J; Pitstick, Rose; Sergeev, Mikhail; Ledbetter, Steven R; Bukanov, Nikolay O; Lane, Monica; Zhang, Kate; Billot, Katy; Carlson, George; Shah, Jagesh; Meijer, Laurent; Beier, David R; Ibraghimov-Beskrovnaya, Oxana

Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice

利用连续注射和错配修复缺陷小鼠提高ENU诱变效率

Gallego-Llamas, Jabier; Timms, Andrew E; Pitstick, Rose; Peters, Janet; Carlson, George A; Beier, David R

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

去除内源性tau蛋白并不能阻止tau蛋白的增殖,但可以降低其神经毒性。

Wegmann, Susanne; Maury, Eduardo A; Kirk, Molly J; Saqran, Lubna; Roe, Allyson; DeVos, Sarah L; Nicholls, Samantha; Fan, Zhanyun; Takeda, Shuko; Cagsal-Getkin, Ozge; William, Christopher M; Spires-Jones, Tara L; Pitstick, Rose; Carlson, George A; Pooler, Amy M; Hyman, Bradley T

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

在早期阿尔茨海默病模型中,淀粉样蛋白加速了tau蛋白的增殖和毒性。

Pooler, Amy M; Polydoro, Manuela; Maury, Eduardo A; Nicholls, Samantha B; Reddy, Snigdha M; Wegmann, Susanne; William, Christopher; Saqran, Lubna; Cagsal-Getkin, Ozge; Pitstick, Rose; Beier, David R; Carlson, George A; Spires-Jones, Tara L; Hyman, Bradley T

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model

内嗅皮层中可溶性病理性tau蛋白会导致早期阿尔茨海默病模型中的突触前功能障碍

Polydoro, Manuela; Dzhala, Volodymyr I; Pooler, Amy M; Nicholls, Samantha B; McKinney, A Patrick; Sanchez, Laura; Pitstick, Rose; Carlson, George A; Staley, Kevin J; Spires-Jones, Tara L; Hyman, Bradley T

Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy

亚甲蓝不能逆转rTg4510小鼠tau蛋白病模型中已存在的神经原纤维缠结病理。

Spires-Jones, Tara L; Friedman, Taylor; Pitstick, Rose; Polydoro, Manuela; Roe, Allyson; Carlson, George A; Hyman, Bradley T

Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease

Mahogunin环指1 E3泛素连接酶的水平不影响朊病毒病

Silvius, Derek; Pitstick, Rose; Ahn, Misol; Meishery, Delisha; Oehler, Abby; Barsh, Gregory S; DeArmond, Stephen J; Carlson, George A; Gunn, Teresa M

Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy

在 rTg4510 tau 蛋白病模型中,tau 蛋白会导致突触丢失,但不会破坏钙稳态。

Kopeikina, Katherine J; Wegmann, Susanne; Pitstick, Rose; Carlson, George A; Bacskai, Brian J; Betensky, Rebecca A; Hyman, Bradley T; Spires-Jones, Tara L