日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease

非人灵长类动物大脑中广泛的AAV1和AAV2介导的转基因表达:对亨廷顿病的启示

Hadaczek, Piotr; Stanek, Lisa; Ciesielska, Agnieszka; Sudhakar, Vivek; Samaranch, Lluis; Pivirotto, Philip; Bringas, John; O'Riordan, Catherine; Mastis, Bryan; San Sebastian, Waldy; Forsayeth, John; Cheng, Seng H; Bankiewicz, Krystof S; Shihabuddin, Lamya S

Cerebellomedullary Cistern Delivery for AAV-Based Gene Therapy: A Technical Note for Nonhuman Primates

基于腺相关病毒(AAV)的基因治疗的小脑延髓池递送:非人灵长类动物技术说明

Samaranch, Lluis; Bringas, John; Pivirotto, Philip; Sebastian, Waldy San; Forsayeth, John; Bankiewicz, Krystof

AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction.

在非人灵长类动物中枢神经系统中,AAV9 介导的非自身蛋白表达会引发由抗原呈递细胞转导驱动的广泛神经炎症

Samaranch Lluis, Sebastian Waldy San, Kells Adrian P, Salegio Ernesto A, Heller Gregory, Bringas John R, Pivirotto Philip, DeArmond Stephen, Forsayeth John, Bankiewicz Krystof S

Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain

非人灵长类动物脑部的动态超极化碳-13磁共振代谢成像

Park, Ilwoo; Larson, Peder E Z; Tropp, James L; Carvajal, Lucas; Reed, Galen; Bok, Robert; Robb, Fraser; Bringas, John; Kells, Adrian; Pivirotto, Philip; Bankiewicz, Krystof; Vigneron, Daniel B; Nelson, Sarah J

Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum

在非人灵长类动物纹状体中,利用新型递送平台,通过磁共振成像引导对流增强递送AAV2-hAADC的安全性和耐受性

San Sebastian, Waldy; Richardson, R Mark; Kells, Adrian P; Lamarre, Clementine; Bringas, John; Pivirotto, Philip; Salegio, Ernesto A; Dearmond, Stephen J; Forsayeth, John; Bankiewicz, Krystof S

Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.

通过对流增强递送 AAV2-GDNF 可促进 MPTP 损伤的多巴胺能系统的再生

Kells Adrian P, Eberling Jamie, Su Xiaomin, Pivirotto Philip, Bringas John, Hadaczek Piotr, Narrow Wade C, Bowers William J, Federoff Howard J, Forsayeth John, Bankiewicz Krystof S

Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys

在老年和帕金森病恒河猴中,对AAV2-GDNF基因转移到多巴胺能黑质纹状体通路进行安全性评估

Su, Xiaomin; Kells, Adrian P; Huang, Eric J; Lee, Han S; Hadaczek, Piotr; Beyer, Janine; Bringas, John; Pivirotto, Philip; Penticuff, Janine; Eberling, Jamie; Federoff, Howard J; Forsayeth, John; Bankiewicz, Krystof S

Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys.

对流增强递送 AAV2-GDNF 对老年恒河猴多巴胺能黑质纹状体通路具有临床相关作用

Johnston Louisa C, Eberling Jamie, Pivirotto Philip, Hadaczek Piotr, Federoff Howard J, Forsayeth John, Bankiewicz Krystof S

Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain

通过对流增强递送至脑部后,腺相关病毒2型在非人灵长类动物体内的生物分布

Cunningham, Janet; Pivirotto, Philip; Bringas, John; Suzuki, Brian; Vijay, Sharmila; Sanftner, Laura; Kitamura, Marina; Chan, Curtis; Bankiewicz, Krystof S

Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys

纹状体局灶性多巴胺可能加剧帕金森猴的运动障碍

Bankiewicz, Krystof S; Daadi, Marcel; Pivirotto, Philip; Bringas, John; Sanftner, Laura; Cunningham, Janet; Forsayeth, John R; Eberling, Jamie L