CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness
利用 CRISPR 技术构建的人类 GATA2 缺陷模型揭示了造血干细胞 (HSPC) 的有丝分裂功能障碍和过早衰老,从而损害了造血功能。
期刊:Leukemia
影响因子:13.4
doi:10.1038/s41375-025-02771-8
Romero-Moya, Damia; Torralba-Sales, Eric; Calvo, Cristina; Marin-Bejar, Oskar; Magallon-Mosella, Maria; Distefano, Maximiliano; Pera, Joan; Castaño, Julio; De Giorgio, Francesca; Gonzalez, Jessica; Iglesias, Arnau; Berenguer-Balaguer, Clara; Schilling, Marcel; Plass, Mireya; Pasquali, Lorenzo; Català, Albert; Molina, Oscar; Wlodarski, Marcin W; Bigas, Anna; Giorgetti, Alessandra