日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FRONTIER-3: a randomised phase 2a study to investigate tozorakimab, an anti-interleukin-33 monoclonal antibody, in early-onset asthma

FRONTIER-3:一项随机 IIa 期研究,旨在研究托佐拉单抗(一种抗白介素-33 单克隆抗体)治疗早发性哮喘的疗效

Corren, Jonathan; Reid, Fred; Moate, Rachel; Jimenez, Eulalia; Sadiq, Muhammad Waqas; Williams, Adam; Rytelewski, Mateusz; Cameron-Christie, Sophia; Muthas, Daniel; Georgi, Benjamin; Brooks, Dennis; Lindqvist, Eva; Kell, Chris; Platt, Adam; Belvisi, Maria G; Pandya, Hitesh

IL-33 is associated with alveolar dysfunction in patients with viral lower respiratory tract disease

IL-33与病毒性下呼吸道疾病患者的肺泡功能障碍相关

Scott, Ian C; Zuydam, Natalie van; Cann, Jennifer A; Negri, Victor Augusti; Tsafou, Kalliopi; Killick, Helen; Liu, Zhi; McCrae, Christopher; Rees, D Gareth; England, Elizabeth; Guscott, Molly A; Houslay, Kirsty; McCormick, Dominique; Freeman, Anna; Schofield, Darren; Freeman, Adrian; Cohen, E Suzanne; Thwaites, Ryan; Brohawn, Zach; Platt, Adam; Openshaw, Peter J M; Semple, Malcolm G; Baillie, J Kenneth; Wilkinson, Tom

ARTEMISIA: a mechanistic study of a novel Janus kinase 1 inhibitor to advance molecular understanding and precision medicine in asthma

ARTEMISIA:一项关于新型 Janus 激酶 1 抑制剂的机制研究,旨在增进对哮喘分子机制的理解并促进精准医疗。

Dosanjh, Davinder Paul Singh; Darrah, Erika; Jensen, Tina Jellesmark; Jevnikar, Zala; Halvorson, Alese; Cardner, Mathias; Hughes, Rod; Grant, Sarah S; Platt, Adam; Brightling, Chris E

Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD

肺部IL-13基因特征与慢性阻塞性肺疾病(COPD)患者组织嗜酸性粒细胞增多相关。

Staples, Karl J; Ackland, Jodie; Lukose, Sruthymol; Angermann, Bastian; Belfield, Graham; Belvisi, Maria; Chaerkady, Raghothama; Etal, Damla; Heinson, Ashley; Hess, Sonja; Hristova, Ventzislava A; Hühn, Michael; McCrae, Christopher; Muthas, Daniel; Öberg, Lisa; Ostridge, Kristoffer; Platt, Adam; Spalluto, C Mirella; Watson, Alastair; Wilkinson, Tom

NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome.

慢性阻塞性肺病患者的非典型流感嗜血杆菌(NTHi)杀菌活性降低,且与不同的微生物群有关

Gopalakrishnan Vancheswaran, Sparklin Ben, Kim Jung Hwan, Bouquet Jerome, Kehl Margaret, Kenny Tara, Morehouse Christopher, Caceres Carolina, Warrener Paul, Hristova Ventzislava A, Wilson Susan, Shandilya Harini, Barnes Arnita, Ruzin Alexey, Wang Junmin, Oberg Lisa, Angermann Bastian, McCrae Christopher, Platt Adam, Muthas Daniel, Hess Sonja, Tkaczyk Christine, Sellman Bret R, Ostridge Kristoffer, Belvisi Maria G, Wilkinson Tom M A, Staples Karl J, DiGiandomenico Antonio

Metabolomic profiling of patients with lupus nephritis reveals unique metabolites that are modulated through type I interferon inhibition by anifrolumab treatment in a phase 2 trial

在一项二期临床试验中,对狼疮性肾炎患者进行代谢组学分析发现,阿尼弗鲁单抗治疗可通过抑制I型干扰素来调节独特的代谢物。

Gavin, Patrick G; Allman, Erik L; Jayne, David; Mysler, Eduardo; Amoura, Zahir; Di Poto, Cristina; Tian, Xiang; Hess, Sonja; Csomor, Eszter; Brohawn, Philip Z; Muthas, Daniel; Platt, Adam; Anzillotti, Consuelo; Stone, Heena; Seth, Asha; Woollard, Kevin; Al-Mossawi, Hussein; Lindholm, Catharina; Ferrari, Nicola

A phase 1 study evaluating the safety, tolerability, and pharmacokinetics of the porcupine inhibitor, AZD5055

一项评估豪猪蛋白酶抑制剂 AZD5055 的安全性、耐受性和药代动力学的 1 期研究

Zhou, Xiao-Hong; Prothon, Susanne; L, Engin; Ferrari, Nicola; Hezaveh, Kebria; Liu, Zhi; Nemes, Szilard; Almquist, Joachim; Williams, Michael L; Sobande, Olami; Gottfridsson, Christer; Gochuico, Bernadette R; Platt, Adam; Brohawn, Zach; Belvisi, Maria G; Goldwater, Ronald; Hornberg, Ellinor; Owen, Caroline A

A novel SPECT-CT imaging platform for quantifying in vivo lung cytokine signals in COPD

一种用于量化慢性阻塞性肺疾病患者体内肺部细胞因子信号的新型SPECT-CT成像平台

Welham, Benjamin; Bennett, Michael; Ostridge, Kristoffer; Guy, Matthew; Zvavamwe, Clint; Chilcott, Anna; Johns, Sandra; Sundram, Francis; Spalluto, Cosma M; Shaw, Emily; Harden, Stephen; Alzetani, Aiman; Lee, Paul; Lawson, Matthew; Lackie, Peter; Michopoulou, Sofia; Henley, Darren; Kong, Alex; Fazleen, Aishath; Cellura, Doriana; McCrae, Christopher; Platt, Adam; Belvisi, Maria G; Staples, Karl J; Wilkinson, Tom

Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences

英国生物银行462,666个全基因组序列中端粒长度的遗传结构

Burren, Oliver S; Dhindsa, Ryan S; Deevi, Sri V V; Wen, Sean; Nag, Abhishek; Mitchell, Jonathan; Hu, Fengyuan; Loesch, Douglas P; Smith, Katherine R; Razdan, Neetu; Olsson, Henric; Platt, Adam; Vitsios, Dimitrios; Wu, Qiang; Codd, Veryan; Nelson, Christopher P; Samani, Nilesh J; March, Ruth E; Wasilewski, Sebastian; Carss, Keren; Fabre, Margarete; Wang, Quanli; Pangalos, Menelas N; Petrovski, Slavé

Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials

在两项 3 期临床试验中,基因表达和蛋白质组学分析表明,使用阿尼弗鲁单抗阻断 I 型干扰素可调节系统性红斑狼疮患者的关键免疫病理通路。

Baker, Tina; Sharifian, Hoda; Newcombe, Paul J; Gavin, Patrick G; Lazarus, Mark N; Ramaswamy, Madhu; White, Wendy I; Ferrari, Nicola; Muthas, Daniel; Tummala, Raj; Morand, Eric F; Furie, Richard A; Vital, Edward M; Chamberlain, Chris; Platt, Adam; Al-Mossawi, Hussein; Brohawn, Philip Z; Csomor, Eszter