Plemel相关文献与解析，生知库 | 链接生命科学的每一步

Peripheral immune response and axonal degeneration in the hind paw skin of mice with experimental autoimmune encephalomyelitis.

实验性自身免疫性脑脊髓炎小鼠后爪皮肤的外周免疫反应和轴突变性。

期刊:Neurobiology of Pain

影响因子:3.2

doi:10.1016/j.ynpai.2025.100207

Klassen Andrea G, Friedman Timothy N, Tenorio Gustavo, Plemel Jason R, Taylor Anna M W, Kerr Bradley J

炎症/感染

发表日期：2026

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Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

衰老样小胶质细胞通过衰老相关分泌表型限制髓鞘再生

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-57632-w

Phillip S Gross ，Violeta Durán-Laforet ，Lana T Ho ，George S Melchor ，Sameera Zia ，Zeeba Manavi ，William E Barclay ，Sung Hyun Lee ，Nataliia Shults ，Sean Selva ，Enrique Alvarez ，Jason R Plemel ，Meng-Meng Fu ，Dorothy P Schafer ，Jeffrey K Huang

Age-impaired remyelination is associated with dysregulated microglial transitions

年龄相关的髓鞘再生障碍与小胶质细胞转化失调有关。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-64906-w

Sameera Zia ，Marianela E Traetta ，Charbel S Baaklini ，Brady P Hammond ，Rebecca K John ，Katherine M Souter ，Niels Meijns ，Larry K A Afun ，Sharmistha Panda ，Fernando González Ibáñez ，Mena K Burr ，Eva Dhupia ，Abhisha M Rathod ，Andre O Faria ，Dhruvish Zaveri ，Sowmya Challa ，Eugene Hahn ，Sohrab B Manesh ，Kelly V Lee ，Madelene F S Ho ，Timothy N Friedman ，Aislinn D Maguire ，Arina Pang ，Olivia Farkas ，Bożena Szulc ，Luiz Tenorio ，Diya Vyas ，Olivia R La Caprara ，Wolfram Tetzlaff ，Sarthak Sinha ，Gregory J Duncan ，Anastassia Voronova ，Bradley J Kerr ，Marie-Eve Tremblay ，Jeff Biernaskie ，Geert Schenk ，Jason R Plemel

Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states.

利用脂多糖重新激活慢性脊髓损伤中的炎症可诱导多种小胶质细胞状态

期刊:Journal of Neuroinflammation

影响因子:10.1

doi:10.1186/s12974-025-03379-6

John Rebecca K, Vogel Sadie P, Zia Sameera, Lee Kelly V, Nguyen Antoinette T, Torres-Espin Abel, Fenrich Keith K, Ng Carmen, Schmidt Emma K A, Vavrek Romana, Raposo Pamela J F, Smith Keira, Fouad Karim, Plemel Jason R

A focus on the normal-appearing white and gray matter within the multiple sclerosis brain: a link to smoldering progression

关注多发性硬化症脑内外观正常的白质和灰质：与缓慢进展的联系

期刊:Acta Neuropathologica

影响因子:9.3

doi:10.1007/s00401-025-02923-1

Muñoz González, Gema; T Hart, Bert A; Bugiani, Marianna; Plemel, Jason R; Schenk, Geert J; Kooij, Gijs; Luchicchi, Antonio

Inhibition of Endoplasmic Reticulum Oxidoreductin 1 Modulates Neuronal Excitability and Nociceptive Sensitivity in Mice

抑制内质网氧化还原酶1可调节小鼠的神经元兴奋性和伤害感受敏感性

期刊:Anesthesiology

影响因子:9.1

doi:10.1097/ALN.0000000000005453

Aislinn D Maguire ,Shawn M Lamothe ,Muhammad Saad Yousuf ,Kree Goss ,Jayadeep Rao ,Gustavo Tenorio ,Sridhar R Kaulagari ,Lori Hazlehurst ,Jason R Plemel ,Anna M W Taylor ,Harley T Kurata ,Thomas Simmen ,Bradley J Kerr

神经科学

发表日期：2025

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Dicer deficiency affects microglial function during demyelination and impairs remyelination.

Dicer 缺乏会影响脱髓鞘过程中小胶质细胞的功能，并损害髓鞘再生

期刊:Neurobiology of Disease

影响因子:5.6

doi:10.1016/j.nbd.2025.106879

Tripathi Ajai, Rai Nagendra Kumar, Perles Aaron, Courtney Haley, Jones Claire, Sapra Adya, Plemel Jason, Dutta Ranjan

细胞生物学

发表日期：2025

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Plasticity of Mouse Dorsal Root Ganglion Neurons by Innate Immune Activation Is Influenced by Electrophysiological Activity

小鼠背根神经节神经元通过先天免疫激活而产生的可塑性受电生理活动的影响

期刊:Journal of Neurochemistry

影响因子:4.2

doi:10.1111/jnc.16292

Timothy N Friedman, Shawn M Lamothe, Aislinn D Maguire, Thomas Hammond, Gustavo Tenorio, Brett J Hilton, Jason R Plemel, Harley T Kurata, Bradley J Kerr

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation.

CSF1R 配体促进小胶质细胞增殖，但并非发育过程中小胶质细胞增殖的唯一调节因子

期刊:Development

影响因子:3.6

doi:10.1242/dev.204610

Hammond Brady P, Zia Sameera, Hahn Eugene, Kapustina Margarita, Lange Tristan, Friesen Sarah, Manek Rupali, Lee Kelly V, Castellanos-Molina Adrian, Bretheau Floriane, Cembrowski Mark S, Kerr Bradley J, Lacroix Steve, Plemel Jason R

Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation

炎症介质直接和间接促进小胶质细胞增殖

Peripheral immune response and axonal degeneration in the hind paw skin of mice with experimental autoimmune encephalomyelitis.

实验性自身免疫性脑脊髓炎小鼠后爪皮肤的外周免疫反应和轴突变性。

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

衰老样小胶质细胞通过衰老相关分泌表型限制髓鞘再生

Age-impaired remyelination is associated with dysregulated microglial transitions

年龄相关的髓鞘再生障碍与小胶质细胞转化失调有关。

Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states.

利用脂多糖重新激活慢性脊髓损伤中的炎症可诱导多种小胶质细胞状态

A focus on the normal-appearing white and gray matter within the multiple sclerosis brain: a link to smoldering progression

关注多发性硬化症脑内外观正常的白质和灰质：与缓慢进展的联系

Inhibition of Endoplasmic Reticulum Oxidoreductin 1 Modulates Neuronal Excitability and Nociceptive Sensitivity in Mice

抑制内质网氧化还原酶1可调节小鼠的神经元兴奋性和伤害感受敏感性

Dicer deficiency affects microglial function during demyelination and impairs remyelination.

Dicer 缺乏会影响脱髓鞘过程中小胶质细胞的功能，并损害髓鞘再生

Plasticity of Mouse Dorsal Root Ganglion Neurons by Innate Immune Activation Is Influenced by Electrophysiological Activity

小鼠背根神经节神经元通过先天免疫激活而产生的可塑性受电生理活动的影响

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation.

CSF1R 配体促进小胶质细胞增殖，但并非发育过程中小胶质细胞增殖的唯一调节因子