日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids

利用脑类器官深度学习筛选加速莱氏综合征药物研发

Menacho, Carmen; Okawa, Satoshi; Álvarez-Merz, Iris; Wittich, Annika; Muñoz-Oreja, Mikel; Lisowski, Pawel; Martín, Mario López; Pentimalli, Tancredi Massimo; Zakin, Shiri; Thevandavakkam, Mathuravani; Jerred, Caleb; Lickfett, Selene; Petersilie, Laura; Rybak-Wolf, Agnieszka; Seibt, Annette; Herebian, Diran; Inak, Gizem; Brodesser, Susanne; Zaliani, Andrea; Mlody, Barbara; Donnelly, Justin; Woleben, Kasey; Soriano, Francesc Xavier; Fernandez-Checa, Jose C; Ventura, Natascia; Cambridge, Sidney; Mayatepek, Ertan; Spinazzola, Antonella; Schuelke, Markus; Rajewsky, Nikolaus; Rossi, Andrea; Peralvarez-Marin, Alex; Distelmaier, Felix; Perlstein, Ethan; Holt, Ian J; Puighermanal, Emma; Pless, Ole; Rose, Christine R; Del Sol, Antonio; Prigione, Alessandro

Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability to Cause Aortopathy.

激活 PRKG1 变体可增强平滑肌细胞变形能力,从而导致主动脉病变。

Jost Marie E, Schweizer Moyra, Henning Philipp, Gorzelanny Christian, Lehners Moritz, Ellinger Bernhard, Boix-Campos Javier, Kux Johan-Moritz, Singh Shubhangi, Fachinger Alexandra, Martinez Pomier Karla, VanSchouwen Bryan, Billing Anja M, Biedenweg Doreen, Schweizer Michaela, Siegel Saskia, Reimer Rudolph, Brandt Mona, Priesmeier Laura, Fuchs Ulrike, Pflaumenbaum Julia, Nikolaev Viacheslav O, Newbury-Ecob Ruth, Wilsdon Anna, Rybczynski Meike, Gehle Petra, Zelarayán Laura C, Stafforst Thorsten, Feil Robert, Rinschen Markus M, Pless Ole, Eaton Philip, Sáez Pablo J, Otto Oliver, Melacini Giuseppe, Demal Till J, Eschenhagen Thomas, Herberg Friedrich W, Cuello Friederike

Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease.

晚发性阿尔茨海默病中,脑毛细血管内皮样细胞表现出屏障功能改变和淀粉样蛋白β转运减少。

Hartmann Carla, Haferkamp Undine, Appelt-Menzel Antje, Barenberg Janica, Brachner Andreas, Ehrhard Toni, Feldhaus Julia, Gerhartl Anna, Hollemann Thomas, Kulka Linda Anna Michelle, Leckzik Selin, Leu Jennifer, Woo Marcel Seungsu, Friese Manuel Alexander, Initiative Alzheimer's Disease Neuroimaging, Metzger Marco, Neuhaus Winfried, Oerter Sabrina, Olzscha Heidi, Pich Andreas, Riemann Dagmar, Pless Ole, Rujescu Dan, Jung Matthias

DPP4 inhibition affects metabolism and inflammation associated pathways in hiPSC-derived steatotic HLCs

DPP4抑制影响hiPSC衍生的脂肪变性HLCs中的代谢和炎症相关通路

Loerch, Christiane; Wruck, Wasco; Wittich, Annika; Hokamp, Rabea; Reiss, Julian; Pless, Ole; Adjaye, James; Graffmann, Nina

Cortical organoid-derived models of the melanoma brain metastatic niche enable prioritization of cancer-targeting drugs.

利用皮质类器官衍生的黑色素瘤脑转移微环境模型,可以对癌症靶向药物进行优先排序。

Krieg Kim, Materna-Reichelt Silvia, Naber Tobias, Rachad Fatima-Zahra, Kauven Pia, Weller Arjen, Haferkamp Undine, Wittich Annika, Zaliani Andrea, Woo Marcel S, Walkenhorst Mark, Siegmund Malte, Harberts Jann, Zierold Robert, Blick Robert, Conze Christian, Muschong Patricia, Miltner Dominik, Friese Manuel A, Mezler Mario, Siegmund Heiko, Evert Katja, Krasemann Susanne, Gužvić Nataša Stojanović, Klein Christoph A, Werner-Klein Melanie, Wegener Joachim, Pless Ole

Optimization and Evaluation of Complementary Degrader Discovery Assays for Application in Screening.

优化和评价互补降解剂发现试验在筛选中的应用

Huchting Johanna, Weller Arjen, Schweizer Moyra, Brandt Mona, Heering Jan, Kuzikov Maria, Wolf Markus, Reinshagen Jeanette, Queisser Markus A, Gribbon Philip, Zaliani Andrea, Pless Ole, Kannt Aimo

Targeting autophagy in disease: established and new strategies

靶向自噬治疗疾病:现有策略和新策略

Kocak, Muhammed; Ezazi Erdi, Saba; Jorba, Guillem; Maestro, Inés; Farrés, Judith; Kirkin, Vladimir; Martinez, Ana; Pless, Ole

Response to: SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe

回应:SARS-CoV-2 和 I 型干扰素信号在脑内皮细胞中的传导:模糊了敌友界限

Krasemann, Susanne; Glatzel, Markus; Pless, Ole

The mechanism of macroautophagy: The movie

巨自噬的机制:电影版

Reggiori, Fulvio; Boya, Patricia; da Costa, David; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Farrés, Judith; Guettler, Sebastian; Kraft, Claudine; Jungbluth, Heinz; Martinez, Ana; Morel, Etienne; Pless, Ole; Proikas-Cezanne, Tassula; Simonsen, Anne

Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis

脂质介质谱可预测复发缓解型多发性硬化症患者对口服乳香提取物治疗的反应

Stürner, Klarissa Hanja; Werz, Oliver; Koeberle, Andreas; Otto, Markus; Pless, Ole; Leypoldt, Frank; Paul, Friedemann; Heesen, Christoph