日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Group a Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination

A组链球菌在纤维蛋白凝块内仍能存活,并能接触到人纤溶酶原,进而发生纤溶和扩散。

Vu, Henry M; Moran, Thomas E; Liang, Zhong; Bao, Yun-Juan; Carles, Paulina G; Keane, Jessica C; Cerney, Madelyn G; Dahnke, Caitlyn N; Flores-Mireles, Ana L; Ploplis, Victoria A; Castellino, Francis J; Lee, Shaun W

Plasminogen missense variants and their involvement in cardiovascular and inflammatory disease

纤溶酶原错义变异及其与心血管和炎症性疾病的关系

Brito-Robinson, Teresa; Ayinuola, Yetunde A; Ploplis, Victoria A; Castellino, Francis J

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

SPHK2/S1P 轴改变平滑肌细胞组蛋白乙酰化物会促进肺动脉高压

A Dushani C U Ranasinghe, Maggie Holohan #, Kalyn M Borger #, Deborah L Donahue, Rafael D Kuc, Martin Gerig, Andrew Kim, Victoria A Ploplis, Francis J Castellino, Margaret A Schwarz

Spike protein receptor-binding domains from SARS-CoV-2 variants of interest bind human ACE2 more tightly than the prototype spike protein

来自目标SARS-CoV-2变种的刺突蛋白受体结合域与人ACE2的结合力比原型刺突蛋白更强。

Charles, Jermilia; McCann, Nathan; Ploplis, Victoria A; Castellino, Francis J

Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection

链球菌溶血素S靶向钠-碳酸氢盐共转运蛋白NBCn1,在A组链球菌感染期间诱导人角质形成细胞的炎症和细胞毒性。

Hammers, Daniel E; Donahue, Deborah L; Tucker, Zachary D; Ashfeld, Brandon L; Ploplis, Victoria A; Castellino, Francis J; Lee, Shaun W

Relationships Between Plasminogen-Binding M-Protein and Surface Enolase for Human Plasminogen Acquisition and Activation in Streptococcus pyogenes

化脓性链球菌中纤溶酶原结合 M 蛋白与表面烯醇化酶对人类纤溶酶原获取和激活的关系

Yetunde A Ayinuola, Sheiny Tjia-Fleck, Bradley M Readnour, Zhong Liang, Olawole Ayinuola, Lake N Paul, Shaun W Lee, Vincent A Fischetti, Victoria A Ploplis, Francis J Castellino

Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation

化脓性链球菌的进化最大限度地提高了A型分选酶切割基序对细胞壁转肽作用的效率。

Readnour, Bradley M; Ayinuola, Yetunde A; Russo, Brady T; Liang, Zhong; Lee, Shaun W; Ploplis, Victoria A; Fischetti, Vincent A; Castellino, Francis J

Shock temporality: international students coping with disrupted lives and suspended futures

冲击性的时间性:国际学生如何应对被打乱的生活和悬而未决的未来

Castellino, Francis J; Chapman, Michael P; Donahue, Deborah L; Thomas, Scott; Moore, Ernest E; Wohlauer, Max V; Fritz, Braxton; Yount, Robert; Ploplis, Victoria; Davis, Patrick; Evans, Edward; Walsh, Mark; Gomes, Catherine

Binding of the kringle-2 domain of human plasminogen to streptococcal PAM-type M-protein causes dissociation of PAM dimers

人纤溶酶原的kringle-2结构域与链球菌PAM型M蛋白的结合导致PAM二聚体解离。

Ayinuola, Olawole; Ayinuola, Yetunde A; Qiu, Cunjia; Lee, Shaun W; Ploplis, Victoria A; Castellino, Francis J

Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence

链球菌利用人类纤溶酶原中的构象锁来促进链激酶裂解和细菌毒力

Yetunde A Ayinuola, Teresa Brito-Robinson, Olawole Ayinuola, Julia E Beck, Diana Cruz-Topete, Shaun W Lee, Victoria A Ploplis, Francis J Castellino