日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Group a Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination

A组链球菌在纤维蛋白凝块内仍能存活,并能接触到人纤溶酶原,进而发生纤溶和扩散。

Vu, Henry M; Moran, Thomas E; Liang, Zhong; Bao, Yun-Juan; Carles, Paulina G; Keane, Jessica C; Cerney, Madelyn G; Dahnke, Caitlyn N; Flores-Mireles, Ana L; Ploplis, Victoria A; Castellino, Francis J; Lee, Shaun W

Plasminogen missense variants and their involvement in cardiovascular and inflammatory disease

纤溶酶原错义变异及其与心血管和炎症性疾病的关系

Brito-Robinson, Teresa; Ayinuola, Yetunde A; Ploplis, Victoria A; Castellino, Francis J

The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI

导尿管膀胱环境会诱发巨噬细胞极化失调,从而加剧细菌性尿路感染。

Marrufo, Armando M; Molina, Jonathan J; Gager, Chris; Andersen, Marissa J; LaBella, Alyssa A; Lucas, Elizabeth R; Wongso, Ellsa; Urmi, Tamanna; Arias-Parbul, Kassandra; Webster, Railyn; Stuckey, Peter V; Kohler, Kurt N; Donahue, Deborah; Ploplis, Victoria A; Flick, Matthew J; Castellino, Francis J; Santiago-Tirado, Felipe H; Flores-Mireles, Ana L

Coagulation factor XII contributes to renin activation, heart failure progression, and mortality

凝血因子XII促进肾素激活、心力衰竭进展和死亡率。

Gladysheva, Inna P; Sullivan, Ryan D; Saleem, Sofiyan; Castellino, Francis J; Ploplis, Victoria A; Reed, Guy L

Spike protein receptor-binding domains from SARS-CoV-2 variants of interest bind human ACE2 more tightly than the prototype spike protein

来自目标SARS-CoV-2变种的刺突蛋白受体结合域与人ACE2的结合力比原型刺突蛋白更强。

Charles, Jermilia; McCann, Nathan; Ploplis, Victoria A; Castellino, Francis J

Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection

链球菌溶血素S靶向钠-碳酸氢盐共转运蛋白NBCn1,在A组链球菌感染期间诱导人角质形成细胞的炎症和细胞毒性。

Hammers, Daniel E; Donahue, Deborah L; Tucker, Zachary D; Ashfeld, Brandon L; Ploplis, Victoria A; Castellino, Francis J; Lee, Shaun W

Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation

化脓性链球菌的进化最大限度地提高了A型分选酶切割基序对细胞壁转肽作用的效率。

Readnour, Bradley M; Ayinuola, Yetunde A; Russo, Brady T; Liang, Zhong; Lee, Shaun W; Ploplis, Victoria A; Fischetti, Vincent A; Castellino, Francis J

Binding of the kringle-2 domain of human plasminogen to streptococcal PAM-type M-protein causes dissociation of PAM dimers

人纤溶酶原的kringle-2结构域与链球菌PAM型M蛋白的结合导致PAM二聚体解离。

Ayinuola, Olawole; Ayinuola, Yetunde A; Qiu, Cunjia; Lee, Shaun W; Ploplis, Victoria A; Castellino, Francis J

Plasminogen Deficiency Significantly Reduces Vascular Wall Disease in a Murine Model of Type IIa Hypercholesterolemia

纤溶酶原缺乏显著降低了 IIa 型高胆固醇血症小鼠模型中的血管壁疾病

Iwaki, Takayuki; Arakawa, Tomohiro; Sandoval-Cooper, Mayra J; Smith, Denise L; Donahue, Deborah; Ploplis, Victoria A; Umemura, Kazuo; Castellino, Francis J

Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution

A组链球菌诱导的人纤溶酶原活化是角质形成细胞伤口回缩和血凝块快速溶解所必需的

Vu, Henry M; Hammers, Daniel E; Liang, Zhong; Nguyen, Gabrielle L; Benz, Mary E; Moran, Thomas E; Higashi, Dustin L; Park, Claudia J; Ayinuola, Yetunde A; Donahue, Deborah L; Flores-Mireles, Ana L; Ploplis, Victoria A; Castellino, Francis J; Lee, Shaun W