日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia.

中和 APOA5 单克隆抗体可减少毛细血管中脂蛋白脂肪酶的含量，并引发高甘油三酯血症。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2528664123
Yang Ye, Beigneux Anne P, Lowe Troy L, Chen Yan Q, Xie Katherine, Jung Hyesoo, Tu Yiping, Yu Rachel G, Scheithauer Julia L, Mehta Shailen, Wu Jerry, Alvarez Lindsay, Davidson W Sean, Birrane Gabriel, Remaley Alan T, Sviridov Denis, Ploug Michael, Zhen Eugene Y, Qian Yuewei, Sloan John H, Siegel Robert W, Konrad Robert J, Fong Loren G, Young Stephen G
单克隆抗体
心血管
APOA5
发表日期：2026
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Structural basis for uPAR binding to an antibody developed for targeted cancer therapy. Mechanistic insights into flexibility, ligand recognition, and molecular imaging

uPAR与靶向癌症治疗抗体结合的结构基础。对柔性、配体识别和分子成像的机制性见解

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.70473
Anane, Rex F; Kumari, Anni; Venugopal, Hari; Trépout, Sylvain; Whisstock, James C; Engelholm, Lars H; Law, Ruby H P; Ploug, Michael
uPAR
肿瘤
肿瘤免疫
uPA
发表日期：2026
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GPIHBP1, lipoprotein lipase, and triglyceride-rich lipoproteins in capillaries of the choroid plexus and circumventricular organs

脉络丛和脑室周围器官毛细血管中的 GPIHBP1、脂蛋白脂肪酶和富含甘油三酯的脂蛋白

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI191867
Song, Wenxin; Hung, Madison; Kozlov, Ellen; Hung, Megan; Tran, Anh P; Carroll, James; Nguyen, Le Phoung; Lowe, Troy L; Kim, Paul; Jung, Hyesoo; Tu, Yiping; Kim, Joonyoung; Presnell, Ashley M; Scheithauer, Julia; Koerner, Jenna P; Yang, Ye; Magaki, Shino D; Williams, Christopher K; Ploug, Michael; Jiang, Haibo; Betsholtz, Christer; Mäe, Maarja Andaloussi; He, Liqun; Beigneux, Anne P; Fong, Loren G; Young, Stephen G
HBP1
神经科学
发表日期：2025
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Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase.

血管生成素样 3 单体在人类血浆中含量丰富，但不能抑制内皮脂肪酶。

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.197827
Walker Sydney G, Chen Yan Q, Sylvers-Davie Kelli L, Dou Alex, Zhen Eugene Y, Qian Yuewei, Wen Yi, Ehsani Mariam, Smith Sydney, Thapa Rakshya, Mercer Maxwell J, Langmack Lucy, Bhattarai Bharat Raj, Ploug Michael, Konrad Robert J, Davies Brandon Sj
Human
心血管
血管生成
发表日期：2025
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Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1.

GPIHBP1 中无序的酸性簇协调脂蛋白脂肪酶与硫酸乙酰肝素的竞争性置换

期刊:Journal of Lipid Research
影响因子:4.1
doi:10.1016/j.jlr.2025.100745
Biswas Anamika, Arshid Samina, Kristensen Kristian Kølby, Jørgensen Thomas J D, Ploug Michael
免疫/内分泌
发表日期：2025
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Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity

APOA5 中的羧基末端序列对于抑制 ANGPTL3/8 活性至关重要

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2322332121
Chen, Yan Q; Yang, Ye; Zhen, Eugene Y; Beyer, Thomas P; Li, Hongxia; Wen, Yi; Ehsani, Mariam; Jackson, Nicholas; Xie, Katherine; Jung, Hyesoo; Scheithauer, Julia L; Kumari, Anni; Birrane, Gabriel; Russell, Anna M; Balasubramaniam, Deepa; Liao, Zhongping; Siegel, Robert W; Qian, Yuewei; Ploug, Michael; Young, Stephen G; Konrad, Robert J
APOA5
发表日期：2024
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Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species

哺乳动物和低等脊椎动物心脏中血管内甘油三酯代谢的不同策略

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.184940
Nguyen, Le Phuong; Song, Wenxin; Yang, Ye; Tran, Anh P; Weston, Thomas A; Jung, Hyesoo; Tu, Yiping; Kim, Paul H; Kim, Joonyoung R; Xie, Katherine; Yu, Rachel G; Scheithauer, Julia; Presnell, Ashley M; Ploug, Michael; Birrane, Gabriel; Arnold, Hannah; Koltowska, Katarzyna; Mäe, Maarja A; Betsholtz, Christer; He, Liqun; Goodwin, Jeffrey L; Beigneux, Anne P; Fong, Loren G; Young, Stephen G
代谢
发表日期：2024
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APOA5 deficiency causes hypertriglyceridemia by reducing amounts of lipoprotein lipase in capillaries

APOA5缺乏症通过减少毛细血管中脂蛋白脂肪酶的含量而导致高甘油三酯血症。

期刊:Journal of Lipid Research
影响因子:4.1
doi:10.1016/j.jlr.2024.100578
Yang, Ye; Konrad, Robert J; Ploug, Michael; Young, Stephen G
APOA5
发表日期：2024
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A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism

毛细血管内皮细胞蛋白GPIHBP1对血浆甘油三酯代谢至关重要。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2211136119
Young, Stephen G; Song, Wenxin; Yang, Ye; Birrane, Gabriel; Jiang, Haibo; Beigneux, Anne P; Ploug, Michael; Fong, Loren G
心血管
代谢
内皮细胞
细胞生物学
HBP1
发表日期：2022
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The Urokinase Receptor (uPAR) as a "Trojan Horse" in Targeted Cancer Therapy: Challenges and Opportunities

尿激酶受体（uPAR）作为靶向癌症治疗中的“特洛伊木马”：挑战与机遇

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers13215376
Metrangolo, Virginia; Ploug, Michael; Engelholm, Lars H
肿瘤
肿瘤免疫
信号转导
uPA
Horse
uPAR
发表日期：2021
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