日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches

人类2型糖尿病中胰岛β细胞功能恢复:转录组特征揭示治疗方法

Suleiman, Mara; Sawatani, Toshiaki; Tesi, Marta; Yi, Xiaoyan; Papadopoulou, Theodora; Rufer, Chantal; Lytrivi, Maria; Bosi, Emanuele; Burdet, Frederic; Fantuzzi, Federica; De Luca, Carmela; Sebastiani, Guido; Saponaro, Chiara; Pugliese, Licia Anna; Del Guerra, Silvia; Pocai, Alessandro; De Simone, Paolo; Ghinolfi, Davide; Boggi, Ugo; Kessler, Camille; Grieco, Giuseppina Emanuela; Fignani, Daniela; Kerr-Conte, Julie; Pattou, François; Nacher, Montserrat; Montanya, Eduard; Mourad, Nizar; Buemi, Antoine; Citi, Valentina; Martelli, Alma; Benedetti, Giada; Calderone, Vincenzo; Rossi, Leonardo; Paolicchi, Aldo; Cardarelli, Francesco; Dotta, Francesco; Eizirik, Decio L; Ibberson, Mark; Marchetti, Piero; Cnop, Miriam; Marselli, Lorella

VEPTP inhibition with an extracellular domain targeting antibody did not restore albuminuria in a mouse model of diabetic kidney disease

使用胞外域靶向抗体抑制 VEPTP 未能恢复糖尿病肾病小鼠模型中的白蛋白尿

Rajashree Rana, Thomas A Natoli, Puneet Khandelwal, Pavlos Pissios, Abdul Bari Muhammad, Vaja Chipashvili, Krista P Farrington, Wen Zhou, Gang Zheng, Nikolay O Bukanov, Alessandro Pocai, Maria Chiara Magnone

The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR

肝脏中的线粒体裂变蛋白 Drp1 是缓解 NASH 所必需的,并可防止线粒体 ISR 的激活

Janos Steffen, Jennifer Ngo, Sheng-Ping Wang, Kevin Williams, Henning F Kramer, George Ho, Carlos Rodriguez, Krishna Yekkala, Chidozie Amuzie, Russell Bialecki, Lisa Norquay, Andrea R Nawrocki, Mark Erion, Alessandro Pocai, Orian S Shirihai, Marc Liesa

A FFAR1 full agonist restores islet function in models of impaired glucose-stimulated insulin secretion and diabetic non-human primates

FFAR1 完全激动剂可恢复葡萄糖刺激胰岛素分泌受损模型和糖尿病非人类灵长类动物的胰岛功能

Brian Rady, Jianying Liu, Hui Huang, Ivona Bakaj, Jenson Qi, S P Lee, Tonya Martin, Lisa Norquay, Mark Player, Alessandro Pocai

PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells

PNPLA3 下调加剧人类肝星状细胞的纤维化反应

Brian Rady, Takahiro Nishio, Debanjan Dhar, Xiao Liu, Mark Erion, Tatiana Kisseleva, David A Brenner, Alessandro Pocai

GRK Inhibition Potentiates Glucagon-Like Peptide-1 Action

GRK 抑制可增强胰高血糖素样肽-1 的作用

Seunghun P Lee, Jenson Qi, Guozhang Xu, Matthew M Rankin, James Littrell, June Zhi Xu, Ivona Bakaj, Alessandro Pocai

Glucagon-like peptide 1 (GLP-1)

胰高血糖素样肽-1 (GLP-1)

Müller, T D; Finan, B; Bloom, S R; D'Alessio, D; Drucker, D J; Flatt, P R; Fritsche, A; Gribble, F; Grill, H J; Habener, J F; Holst, J J; Langhans, W; Meier, J J; Nauck, M A; Perez-Tilve, D; Pocai, A; Reimann, F; Sandoval, D A; Schwartz, T W; Seeley, R J; Stemmer, K; Tang-Christensen, M; Woods, S C; DiMarchi, R D; Tschöp, M H

A Randomized Controlled Trial on the Efficacy of a Psychosocial Behavioral Intervention to Improve the Lifestyle of Patients With Severe Mental Disorders: Study Protocol

一项关于心理社会行为干预改善重性精神障碍患者生活方式疗效的随机对照试验:研究方案

Sampogna, Gaia; Fiorillo, Andrea; Luciano, Mario; Del Vecchio, Valeria; Steardo, Luca Jr; Pocai, Benedetta; Barone, Marina; Amore, Mario; Pacitti, Francesca; Dell'Osso, Liliana; Di Lorenzo, Giorgio; Maj, Mario

A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice

本研究比较了二肽基肽酶-4 (DPP-4) 抑制剂阿格列汀、利格列汀、沙格列汀、西格列汀和维格列汀在小鼠体内的结合特性、DPP-4抑制活性和降血糖疗效。

Berger, Joel P; SinhaRoy, Ranabir; Pocai, Alessandro; Kelly, Theresa M; Scapin, Giovanna; Gao, Ying-Duo; Pryor, Kelly Ann D; Wu, Joseph K; Eiermann, George J; Xu, Shiyao S; Zhang, Xiaoping; Tatosian, Daniel A; Weber, Ann E; Thornberry, Nancy A; Carr, Richard D

Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice

胰高血糖素样受体1/胰高血糖素双重激动剂可显著增强小鼠肝脏脂质清除率并抑制从头脂肪生成。

More, Vijay R; Lao, Julie; McLaren, David G; Cumiskey, Anne-Marie; Murphy, Beth Ann; Chen, Ying; Previs, Stephen; Stout, Steven; Patel, Rajesh; Satapati, Santhosh; Li, Wenyu; Kowalik, Edward; Szeto, Daphne; Nawrocki, Andrea; Pocai, Alessandro; Wang, Liangsu; Carrington, Paul