日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Stimulation of histamine H(1)-receptors produces a positive inotropic effect in the human atrium

组胺H(1)受体的刺激可对人体心房产生正性肌力作用

Pham, Thanh Hoai; Abella, Lina Maria Rayo; Hadova, Katarina; Klimas, Jan; Dhein, Stefan; Pockes, Steffen; Schlicht, Jonas Manfred Albert; Hofmann, Britt; Kirchhefer, Uwe; Neumann, Joachim; Gergs, Ulrich

Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment

纳米圆盘环境中无细胞合成的人类组胺 2 受体/Gs 复合物的低温电子显微镜结构

Zoe Köck #, Kilian Schnelle #, Margherita Persechino, Simon Umbach, Hannes Schihada, Dovile Januliene, Kristian Parey, Steffen Pockes, Peter Kolb, Volker Dötsch, Arne Möller, Daniel Hilger, Frank Bernhard

Clonidine stimulates force of contraction via histamine H2 receptors in the human atrium

可乐定通过人心房的组胺 H2 受体刺激收缩力

Joachim Neumann, Steffen Pockes, Laura J Humphrys, Denise Mönnich, Lisa Forster, Uwe Kirchhefer, Britt Hofmann, Ulrich Gergs

Development of Fluorescent AF64394 Analogues Enables Real-Time Binding Studies for the Orphan Class A GPCR GPR3

荧光 AF64394 类似物的开发使对孤儿 A 类 GPCR GPR3 进行实时结合研究成为可能

Merlin Bresinsky, Aida Shahraki, Peter Kolb, Steffen Pockes, Hannes Schihada

An electrophilic fragment screening for the development of small molecules targeting caspase-2

亲电片段筛选用于开发针对 caspase-2 的小分子

Matthew E Cuellar, Mu Yang, Surendra Karavadhi, Ya-Qin Zhang, Hu Zhu, Hongmao Sun, Min Shen, Matthew D Hall, Samarjit Patnaik, Karen H Ashe, Michael A Walters, Steffen Pockes

Ergometrine stimulates histamine H2 receptors in the isolated human atrium

麦角新碱刺激人类心房分离部位的组胺 H2 受体

Hannes Jacob, Pauline Braekow, Britt Hofmann, Uwe Kirchhefer, Lisa Forster, Denise Mönnich, Laura J Humphrys, Steffen Pockes, Joachim Neumann, Ulrich Gergs

Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314

基于肽 AcVDVAD-CHO 和 Caspase-2 介导的 Tau 裂解序列 YKPVD314 的新型 Caspase-2 抑制剂的结构设计和生物学评价

Merlin Bresinsky, Jessica M Strasser, Bernadette Vallaster, Peng Liu, William M McCue, Jessica Fuller, Alexander Hubmann, Gurpreet Singh, Kathryn M Nelson, Matthew E Cuellar, Carrie M Wilmot, Barry C Finzel, Karen H Ashe, Michael A Walters, Steffen Pockes

Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties

哌嗪和哌啶衍生物作为组胺 H3 和 Sigma-1 受体拮抗剂的结构和分子见解,具有良好的抗伤害特性

Katarzyna Szczepańska, Sabina Podlewska, Maria Dichiara, Davide Gentile, Vincenzo Patamia, Niklas Rosier, Denise Mönnich, Ma Carmen Ruiz Cantero, Tadeusz Karcz, Dorota Łażewska, Agata Siwek, Steffen Pockes, Enrique J Cobos, Agostino Marrazzo, Holger Stark, Antonio Rescifina, Andrzej J Bojarski, Eman

Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis

根据 caspase-2 介导的蛋白水解的特定位点表征 caspase-2 抑制剂

Merlin Bresinsky, Jessica M Strasser, Alexander Hubmann, Bernadette Vallaster, William M McCue, Jessica Fuller, Gurpreet Singh, Kathryn M Nelson, Matthew E Cuellar, Barry C Finzel, Karen H Ashe, Michael A Walters, Steffen Pockes

Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists

开发构象组胺 H3 受体生物传感器用于同步筛选激动剂和反向激动剂

Hannes Schihada, Xiaoyuan Ma, Ulrike Zabel, Henry F Vischer, Gunnar Schulte, Rob Leurs, Steffen Pockes, Martin J Lohse