日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors

靶向 HER2 或 EGFR 和 CD3 的精准激活 T 细胞衔接器可减轻实体瘤免疫疗法的靶向非肿瘤毒性。

Fiore Cattaruzza ,Ayesha Nazeer ,Milton To ,Mikhail Hammond ,Caitlin Koski ,Lucas Y Liu ,V Pete Yeung ,Deena A Rennerfeldt ,Angela Henkensiefken ,Michael Fox ,Sharon Lam ,Kari M Morrissey ,Zachary Lange ,Vladimir N Podust ,Mika K Derynck ,Bryan A Irving ,Volker Schellenberger

Miconazole-like Scaffold is a Promising Lead for Naegleria fowleri-Specific CYP51 Inhibitors

咪康唑类骨架是针对福氏耐格里阿米巴原虫的CYP51特异性抑制剂的有前景的先导化合物

Sharma, Vandna; Madia, Valentina Noemi; Tudino, Valeria; Nguyen, Jennifer V; Debnath, Anjan; Messore, Antonella; Ialongo, Davide; Patacchini, Elisa; Palenca, Irene; Basili Franzin, Silvia; Seguella, Luisa; Esposito, Giuseppe; Petrucci, Rita; Di Matteo, Paola; Bortolami, Martina; Saccoliti, Francesco; Di Santo, Roberto; Scipione, Luigi; Costi, Roberta; Podust, Larissa M

A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides

结合 THIOMAB 抗体和 XTEN 多肽的均质高 DAR 抗体-药物偶联平台

Neelie Zacharias, Vladimir N Podust, Kimberly K Kajihara, Douglas Leipold, Geoffrey Del Rosario, Desiree Thayer, Emily Dong, Maciej Paluch, David Fischer, Kai Zheng, Corinna Lei, Jintang He, Carl Ng, Dian Su, Luna Liu, Shabkhaiz Masih, William Sawyer, Jeff Tinianow, Jan Marik, Victor Yip, Guangmin L

Essential Role of Loop Dynamics in Type II NRPS Biomolecular Recognition

环动力学在II型NRPS生物分子识别中的关键作用

Corpuz, Joshua C; Patel, Ashay; Davis, Tony D; Podust, Larissa M; McCammon, J Andrew; Burkart, Michael D

Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway

来自 Tirandamycin 生物合成途径的多功能 P450 单加氧酶 TamI 进行 C─H 迭代氧化的分子基础

Sean A Newmister, Kinshuk Raj Srivastava, Rosa V Espinoza, Kersti Caddell Haatveit, Yogan Khatri, Rachel M Martini, Marc Garcia-Borràs, Larissa M Podust, K N Houk, David H Sherman

1152. Characteristics of Patients with Invasive Infections Caused by Trichosporon asahii

1152. 由朝日毛孢子菌引起的侵袭性感染患者的特征

Podust, L M; Poulos, T L; Waterman, M R; Kim, Jinyeong; Kim, Min Jae; Chong, Yong Pil; Kim, Sung-Han; Choi, Sang-Ho; Lee, Sang-Oh; Woo, Jun Hee; Kim, Yang Soo; Jung, Jiwon

The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii

抗真菌药物伊沙康唑对棘阿米巴既有杀阿米巴原虫作用,也有杀囊肿作用。

Shing, Brian; Singh, Seema; Podust, Larissa M; McKerrow, James H; Debnath, Anjan

Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole

卡氏棘阿米巴 CYP51 的域交换二聚化和艾沙康唑的独特失活机制

Vandna Sharma, Brian Shing, Lilian Hernandez-Alvarez, Anjan Debnath, Larissa M Podust

Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of Naegleria fowleri Sterol Δ8-Δ7-Isomerase and Phenotypic Assays

通过福氏耐格里阿米巴原虫甾醇 Δ8-Δ7-异构酶分子对接筛选和表型分析鉴定四种无毒杀阿米巴原虫化合物

Da Shi, Kirti Kandhwal Chahal, Patricia Oto, Louis-Felix Nothias, Anjan Debnath, James H McKerrow, Larissa M Podust, Ruben Abagyan

Short-lived neutral FMN and FAD semiquinones are transient intermediates in cryo-reduced yeast NADPH-cytochrome P450 reductase

短寿命的中性FMN和FAD半醌是低温还原酵母NADPH-细胞色素P450还原酶中的瞬态中间体。

Davydov, Roman M; Jennings, Gareth; Hoffman, Brian M; Podust, Larissa M