日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy

在体外扩增过程中重新定向葡萄糖通量可产生表观遗传和代谢方面更优的T细胞,用于癌症免疫治疗。

Andrew T Frisch ,Yiyang Wang ,Bingxian Xie ,Aaron Yang ,B Rhodes Ford ,Supriya Joshi ,Katarzyna M Kedziora ,Ronal Peralta ,Drew Wilfahrt ,Steven J Mullett ,Kellie Spahr ,Konstantinos Lontos ,Jessica A Jana ,Victoria G Dean ,William G Gunn ,Stacy Gelhaus ,Amanda C Poholek ,Dayana B Rivadeneira ,Greg M Delgoffe

AMPK agonism optimizes the in vivo activation and antileukemic efficacy of chimeric antigen receptor T cells.

AMPK激动剂可优化嵌合抗原受体T细胞的体内激活和抗白血病功效。

Braverman Erica, Qin Mengtao, Ampudia-Mesias Elisabet, Schuler Herbert Tres, Brown Harrison, Murdych Lukas, Titus Ann, MacLean Allison, Kanagala Bhavya, Wittmann Christopher, Ramgopal Archana, Kemp Felicia, Mullet Steven J, Yang Aaron, Poholek Amanda C, Gelhaus Stacy, Byersdorfer Craig

IL-9 and Blimp-1 protects the transcriptional identity of group 2 innate lymphocytes in allergic asthma.

IL-9 和 Blimp-1 保护过敏性哮喘中 2 组固有淋巴细胞的转录特性

Zheng Yibo, Zhang Jinyi, Yang Aaron, He Kun, Creech Arianna, Schwartz Daniella M, Gottschalk Rachel A, Bouladoux Nicolas, Belkaid Yasmine, Poholek Amanda C

A unified network systems approach uncovers a core novel program underlying T follicular helper cell differentiation.

统一的网络系统方法揭示了 T 滤泡辅助细胞分化背后的核心新程序

Omelchenko Alisa A, Rahman Syed A, Viswanadham Vinayak V, Yuen Grace J, Del Rio Estrada Perla M, D'Onofrio Valentino, Chen Yijia, Sun Na, Mattoo Hamid, Varma Chinmay G, Salgado Gonzalo, Nava Maribel S, Ruiz Lady C, Rivera Dafne D, Rios Santiago A, Kasturi Sudhir P, Ribeiro Susan P, Shlomchik Mark J, Poholek Amanda C, Pillai Shiv S, Elsner Rebecca A, Mahajan Vinay S, Das Jishnu

SLIDE: Significant Latent Factor Interaction Discovery and Exploration across biological domains

幻灯片:跨生物学领域的重要潜在因素交互作用的发现与探索

Rahimikollu, Javad; Xiao, Hanxi; Rosengart, AnnaElaine; Rosen, Aaron B I; Tabib, Tracy; Zdinak, Paul M; He, Kun; Bing, Xin; Bunea, Florentina; Wegkamp, Marten; Poholek, Amanda C; Joglekar, Alok V; Lafyatis, Robert A; Das, Jishnu

Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism

耗竭的T细胞功能障碍是由MCT11介导的乳酸代谢加剧的。

Ronal M Peralta ,Bingxian Xie ,Konstantinos Lontos ,Hector Nieves-Rosado ,Kellie Spahr ,Supriya Joshi ,B Rhodes Ford ,Kevin Quann ,Andrew T Frisch ,Victoria Dean ,Mary Philbin ,Anthony R Cillo ,Sebastian Gingras ,Amanda C Poholek ,Lawrence P Kane ,Dayana B Rivadeneira ,Greg M Delgoffe

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T(H)2 cells in response to inhaled allergen.

IL-2 的空间微环境与 IL-10 结合,驱动肺部迁移性 T(H)2 细胞响应吸入的过敏原

He Kun, Xiao Hanxi, MacDonald William A, Mehta Isha, Kishore Akash, Vincent Augusta, Xu Zhongli, Ray Anuradha, Chen Wei, Weaver Casey T, Lambrecht Bart N, Das Jishnu, Poholek Amanda C

Innovative super-resolution in spatial transcriptomics: a transformer model exploiting histology images and spatial gene expression

空间转录组学中的创新超分辨率技术:利用组织学图像和空间基因表达的Transformer模型

Zhao, Chongyue; Xu, Zhongli; Wang, Xinjun; Tao, Shiyue; MacDonald, William A; He, Kun; Poholek, Amanda C; Chen, Kong; Huang, Heng; Chen, Wei

Interleukin (IL)-1/IL-6-Inhibitor-Associated Drug Reaction With Eosinophilia and Systemic Symptoms (DReSS) in Systemic Inflammatory Illnesses

系统性炎症疾病中白细胞介素(IL)-1/IL-6抑制剂相关嗜酸性粒细胞增多症和系统性症状的药物反应(DReSS)

Saper, Vivian E; Tian, Lu; Verstegen, Ruud H J; Conrad, Carol K; Cidon, Michal; Hopper, Rachel K; Kuo, Christin S; Osoegawa, Kazutoyo; Baszis, Kevin; Bingham, Catherine A; Ferguson, Ian; Hahn, Timothy; Horne, Annacarin; Isupova, Eugenia A; Jones, Jordan T; Kasapcopur, Özgür; Klein-Gitelman, Marisa S; Kostik, Mikhail M; Ozen, Seza; Phadke, Omkar; Prahalad, Sampath; Randell, Rachel L; Sener, Seher; Stingl, Cory; Abdul-Aziz, Rabheh; Akoghlanian, Shoghik; Al Julandani, Dalila; Alvarez, Marcela B; Bader-Meunier, Brigitte; Balay-Dustrude, Erin E; Balboni, Imelda; Baxter, Sarah K; Berard, Roberta A; Bhattad, Sagar; Bolaria, Roxana; Boneparth, Alexis; Cassidy, Elaine A; Co, Dominic O; Collins, Kathleen P; Dancey, Paul; Dickinson, Aileen M; Edelheit, Barbara S; Espada, Graciela; Flanagan, Elaine R; Imundo, Lisa F; Jindal, Ankur K; Kim, Hyoun-Ah; Klaus, Günter; Lake, Carol; Lapin, W Blaine; Lawson, Erica F; Marmor, Itay; Mombourquette, Joy; Ogunjimi, Benson; Olveda, Rebecca; Ombrello, Michael J; Onel, Karen; Poholek, Catherine; Ramanan, Athimalaipet V; Ravelli, Angelo; Reinhardt, Adam; Robinson, Amanda D; Rouster-Stevens, Kelly; Saad, Nadine; Schneider, Rayfel; Selmanovic, Velma; Sefic Pasic, Irmina; Shenoi, Susan; Shilo, Natalie R; Soep, Jennifer B; Sura, Angeli; Taber, Sarah F; Tesher, Melissa; Tibaldi, Jessica; Torok, Kathryn S; Tsin, Cathy Mei; Vasquez-Canizares, Natalia; Villacis Nunez, Diana S; Way, Emily E; Whitehead, Benjamin; Zemel, Lawrence S; Sharma, Surbhi; Fernández-Viña, Marcelo A; Mellins, Elizabeth D

Systems immunology approaches to study T cells in health and disease

利用系统免疫学方法研究健康和疾病状态下的T细胞

Yang, Aaron; Poholek, Amanda C