First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sphingosine-1 phosphate receptor-1 agonist for endothelial protection
首次人体研究评估了SAR247799（一种选择性G蛋白偏向性鞘氨醇-1磷酸受体-1激动剂，用于内皮保护）单次和多次口服给药的安全性、耐受性、药代动力学和药效学。
期刊:British Journal of Clinical Pharmacology
影响因子:3
doi:10.1111/bcp.14422
Bergougnan, Luc; Armani, Sara; Golor, Georg; Tardat, Agnes; Vitse, Olivier; Hurbin, Fabrice; Scemama, Michel; Poitiers, Franck; Radzik, David; Gaudin, Christophe; Hovsepian, Lionel; Muslin, Anthony J; Kirkesseli, Stephane; Deutsch, Paul; Parkar, Ashfaq A
