Pojun相关文献与解析，生知库 | 链接生命科学的每一步

Novel C5α-substituted carbapenems enhance Mycobacterium abscessus killing via selective target binding and reduced hydrolysis by Bla(Mab)

新型 C5α 取代的碳青霉烯类抗生素通过选择性靶标结合和减少 Bla(Mab) 水解作用增强对脓肿分枝杆菌的杀灭作用。

期刊:Antimicrobial Agents and Chemotherapy

Shin, Eunjeong; Taracila, Magdalena A; Quan, Pojun; Khan, Md Mahbub Kabir; Cox, Jonathan; Patel, Diya; Dousa, Khalid M; Parmar, Aetan; Nantongo, Mary; Nguyen, David C; Rubin, Eric J; Holland, Steven M; Kreiswirth, Barry N; Buynak, John D; Bonomo, Robert A

发表日期：2025

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Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase

C5α-甲基取代的碳青霉烯类抗生素NA-1-157的旋转灵活性受限，导致其对GES-5碳青霉烯酶具有强效抑制作用。

期刊:ACS Infectious Diseases

影响因子:3.8

doi:10.1021/acsinfecdis.3c00683

Stewart, Nichole K; Toth, Marta; Quan, Pojun; Beer, Michael; Buynak, John D; Smith, Clyde A; Vakulenko, Sergei B

发表日期：2024

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Decarboxylation of the Catalytic Lysine Residue by the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the OXA-58 Carbapenemase

C5α-甲基取代的碳青霉烯类抗生素NA-1-157通过催化赖氨酸残基的脱羧作用，有效抑制OXA-58碳青霉烯酶的活性。

期刊:ACS Infectious Diseases

影响因子:3.8

doi:10.1021/acsinfecdis.4c00671

Toth, Marta; Stewart, Nichole K; Maggiolo, Ailiena O; Quan, Pojun; Khan, Md Mahbub Kabir; Buynak, John D; Smith, Clyde A; Vakulenko, Sergei B

发表日期：2024

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The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases

C5α-甲基取代的碳青霉烯类抗生素NA-1-157对产生OXA-48型碳青霉烯酶的克雷伯氏菌属分离株表现出强效活性。

期刊:ACS Infectious Diseases

影响因子:3.8

doi:10.1021/acsinfecdis.3c00059

Smith, Clyde A; Stewart, Nichole K; Toth, Marta; Quan, Pojun; Buynak, John D; Vakulenko, Sergei B

发表日期：2023

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C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation

C6羟甲基取代的碳青霉烯类抗生素MA-1-206通过抑制脱酰基作用来抑制鲍曼不动杆菌的主要碳青霉烯酶OXA-23。

期刊:mBio

影响因子:4.7

doi:10.1128/mbio.00367-22

Stewart, Nichole K; Toth, Marta; Alqurafi, Maha A; Chai, Weirui; Nguyen, Thu Q; Quan, Pojun; Lee, Mijoon; Buynak, John D; Smith, Clyde A; Vakulenko, Sergei B

发表日期：2022

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Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β-Lactamase Inhibitors

非典型修饰的卡巴培南类抗生素在没有 β-内酰胺酶抑制剂的情况下表现出增强的抗分枝杆菌活性

期刊:ACS Infectious Diseases

影响因子:4

doi:10.1021/acsinfecdis.1c00185

Rashmi Gupta, Noora M S A Al-Kharji, Maha A Alqurafi, Thu Q Nguyen, Weirui Chai, Pojun Quan, Riya Malhotra, Breven S Simcox, Phil Mortimer, Leighanne A Brammer Basta, Kyle H Rohde, John D Buynak

微生物学

发表日期：2021

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Dual mechanism of the OXA-23 carbapenemase inhibition by the carbapenem NA-1-157

碳青霉烯类抗生素NA-1-157对OXA-23碳青霉烯酶的双重抑制机制

Novel C5α-substituted carbapenems enhance Mycobacterium abscessus killing via selective target binding and reduced hydrolysis by Bla(Mab)

新型 C5α 取代的碳青霉烯类抗生素通过选择性靶标结合和减少 Bla(Mab) 水解作用增强对脓肿分枝杆菌的杀灭作用。

Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase

C5α-甲基取代的碳青霉烯类抗生素NA-1-157的旋转灵活性受限，导致其对GES-5碳青霉烯酶具有强效抑制作用。

Decarboxylation of the Catalytic Lysine Residue by the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the OXA-58 Carbapenemase

C5α-甲基取代的碳青霉烯类抗生素NA-1-157通过催化赖氨酸残基的脱羧作用，有效抑制OXA-58碳青霉烯酶的活性。

The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases

C5α-甲基取代的碳青霉烯类抗生素NA-1-157对产生OXA-48型碳青霉烯酶的克雷伯氏菌属分离株表现出强效活性。

C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation

C6羟甲基取代的碳青霉烯类抗生素MA-1-206通过抑制脱酰基作用来抑制鲍曼不动杆菌的主要碳青霉烯酶OXA-23。

Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β-Lactamase Inhibitors

非典型修饰的卡巴培南类抗生素在没有 β-内酰胺酶抑制剂的情况下表现出增强的抗分枝杆菌活性