Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
酪氨酸磷酸化抑制PKM2,从而促进瓦博格效应和肿瘤生长。
期刊:Science Signaling
影响因子:6.6
doi:10.1126/scisignal.2000431
Hitosugi, Taro; Kang, Sumin; Vander Heiden, Matthew G; Chung, Tae-Wook; Elf, Shannon; Lythgoe, Katherine; Dong, Shaozhong; Lonial, Sagar; Wang, Xu; Chen, Georgia Z; Xie, Jianxin; Gu, Ting-Lei; Polakiewicz, Roberto D; Roesel, Johannes L; Boggon, Titus J; Khuri, Fadlo R; Gilliland, D Gary; Cantley, Lewis C; Kaufman, Jonathan; Chen, Jing