Metronomic cyclophosphamide attenuates mTOR-mediated expansion of regulatory T cells, but does not impact clinical outcome in patients with metastatic renal cell cancer treated with everolimus
节拍式环磷酰胺可减弱 mTOR 介导的调节性 T 细胞扩增,但不影响接受依维莫司治疗的转移性肾细胞癌患者的临床结局。
期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-019-02313-z
Werter, Inge M; Huijts, Charlotte M; Lougheed, Sinéad M; Hamberg, Paul; Polee, Marco B; Tascilar, Metin; Los, Maartje; Haanen, John B A G; Helgason, Helgi H; Verheul, Henk M; de Gruijl, Tanja D; van der Vliet, Hans J