日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

4E-BP inhibition ameliorates heart failure through translational upregulation of SERCA2a and modulation of mitochondrial redox signaling in cardiomyocytes

4E-BP抑制剂通过上调SERCA2a的翻译和调节心肌细胞中的线粒体氧化还原信号传导来改善心力衰竭。

Gao, Junling; Lan, Ting; Xu, Xin; Guo, Haipeng; Wang, Siyu; Zhang, Ping; Polunovsky, Vitaly A; Sonenberg, Nahum; Bitterman, Peter B; Bache, Robert J; Hu, Xinli; Lu, Zhongbing; Chen, Yingjie

eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells

eIF4E阈值水平在调控乳腺干细胞和腔祖细胞的正常和肿瘤性增殖方面存在差异。

Avdulov, Svetlana; Herrera, Jeremy; Smith, Karen; Peterson, Mark; Gomez-Garcia, Jose R; Beadnell, Thomas C; Schwertfeger, Kathryn L; Benyumov, Alexey O; Manivel, J Carlos; Li, Shunan; Bielinsky, Anja-Katrin; Yee, Douglas; Bitterman, Peter B; Polunovsky, Vitaly A

Translational control of the fibroblast-extracellular matrix association: An application to pulmonary fibrosis

成纤维细胞-细胞外基质结合的翻译调控:在肺纤维化中的应用

Nho, Richard Seonghun; Polunovsky, Vitaly

Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation

通过逆转异常的eIF4F介导的翻译来攻击致癌回路的关键节点

Bitterman, Peter B; Polunovsky, Vitaly A

Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype

Cap依赖性mRNA翻译和泛素-蛋白酶体系统协同作用促进ERBB2依赖性食管癌表型

O A Issaenko, P B Bitterman, V A Polunovsky, P S Dahlberg

Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense

真核起始因子 4E 结合蛋白家族:肺癌防御中翻译控制检查点的哨兵

Yong Y Kim, Linda Von Weymarn, Ola Larsson, Danhua Fan, Jon M Underwood, Mark S Peterson, Stephen S Hecht, Vitaly A Polunovsky, Peter B Bitterman

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

通过靶向帽子依赖性翻译来无毒化学阻断上皮-间质转化

Brahma Ghosh, Alexey O Benyumov, Phalguni Ghosh, Yan Jia, Svetlana Avdulov, Peter S Dahlberg, Mark Peterson, Karen Smith, Vitaly A Polunovsky, Peter B Bitterman, Carston R Wagner

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein

表达、纯化和表征重组小鼠翻译起始因子eIF4E作为二氢叶酸还原酶(DHFR)融合蛋白

Ghosh, Phalguni; Cheng, Jilin; Chou, Tsui-Fen; Jia, Yan; Avdulov, Svetlana; Bitterman, Peter B; Polunovsky, Vitaly A; Wagner, Carston R

Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency

翻译调控细胞命运:翻译抑制因子4E-BP1上磷酸化位点的可用性决定其促凋亡能力

Li, Shunan; Sonenberg, Nahum; Gingras, Anne-Claude; Peterson, Mark; Avdulov, Svetlana; Polunovsky, Vitaly A; Bitterman, Peter B

Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc

程序性细胞死亡的翻译调控:真核翻译起始因子4E阻断生长因子限制性成纤维细胞的凋亡,这些成纤维细胞具有生理表达或失调的Myc蛋白。

Polunovsky, V A; Rosenwald, I B; Tan, A T; White, J; Chiang, L; Sonenberg, N; Bitterman, P B