Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1α and VEGFA and concurrent inhibition of nuclear factor of activated T cell 1 (NFAT1) activation.
内皮抑制素通过拮抗多种血管内皮生长因子受体 2 (VEGFR2) 诱发的信号通路来影响血管生成：转录抑制缺氧诱导因子 1α 和 VEGFA，同时抑制活化 T 细胞核因子 1 (NFAT1) 的活化
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M112.401786
Goyal Atul, Poluzzi Chiara, Willis Chris D, Smythies James, Shellard Adam, Neill Thomas, Iozzo Renato V
信号转导
细胞生物学
Angiogenesis
EGFR
FAT1
血管生成
