日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The inhibition of necroptosis prevents neuronal death in a mouse model of Alzheimer’s disease pathology

抑制坏死性凋亡可预防阿尔茨海默病小鼠模型中的神经元死亡

Pillai, Jagan A; Bena, James; Tousi, Babak; Rothenberg, Kasia; Keene, C Dirk; Leverenz, James B; Polydoro, Manuela; Geric, Ivana; Zheng, Jin; Bisgaard, Tina Sommer; Comer, Ashley; Sans, Laura; Lu, Ashley; Vilstrup, Joachim; Wolfs, Leen; Nair, Arya; Andersen, Morten S; Frederiksen, Ninna; Flagstad, Peter; Dalby, Maria; Balice‐Gordon, Rita; Plath, Niels; Hemmer, Brittany M; Grau‐Perales, Alejandro B; Ferreira, Ana Catarina; Pallikunnath, Ralphyn; Rosenstadt, Jacob L; Castellano, Joseph M; Moonen, Sebastiaan; Koper, Marta J; Ronisz, Alicja; Ospitalieri, Simona; Vegh, Zsuzsanna; T’Syen, Dries; Rabe, Sabine; Staufenbiel, Matthias; De Strooper, Bart; Balusu, Sriram; Thal, Dietmar Rudolf

Targeting tau: Clinical trials and novel therapeutic approaches

靶向tau蛋白:临床试验和新型治疗方法

VandeVrede, Lawren; Boxer, Adam L; Polydoro, Manuela

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

在早期阿尔茨海默病模型中,淀粉样蛋白加速了tau蛋白的增殖和毒性。

Pooler, Amy M; Polydoro, Manuela; Maury, Eduardo A; Nicholls, Samantha B; Reddy, Snigdha M; Wegmann, Susanne; William, Christopher; Saqran, Lubna; Cagsal-Getkin, Ozge; Pitstick, Rose; Beier, David R; Carlson, George A; Spires-Jones, Tara L; Hyman, Bradley T

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model

内嗅皮层中可溶性病理性tau蛋白会导致早期阿尔茨海默病模型中的突触前功能障碍

Polydoro, Manuela; Dzhala, Volodymyr I; Pooler, Amy M; Nicholls, Samantha B; McKinney, A Patrick; Sanchez, Laura; Pitstick, Rose; Carlson, George A; Staley, Kevin J; Spires-Jones, Tara L; Hyman, Bradley T

Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy

亚甲蓝不能逆转rTg4510小鼠tau蛋白病模型中已存在的神经原纤维缠结病理。

Spires-Jones, Tara L; Friedman, Taylor; Pitstick, Rose; Polydoro, Manuela; Roe, Allyson; Carlson, George A; Hyman, Bradley T

The intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

淀粉样蛋白β和tau蛋白在阿尔茨海默病谷氨酸能突触功能障碍和崩解中的相互作用

Crimins, Johanna L; Pooler, Amy; Polydoro, Manuela; Luebke, Jennifer I; Spires-Jones, Tara L

Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology

在早期阿尔茨海默病rTgTauEC模型中,tau蛋白与淀粉样蛋白的相互作用表明,淀粉样蛋白诱导的轴突投射破坏和轴突病理加剧。

Pooler, Amy M; Polydoro, Manuela; Wegmann, Susanne K; Pitstick, Rose; Kay, Kevin R; Sanchez, Laura; Carlson, George A; Gomez-Isla, Teresa; Albers, Mark W; Spires-Jones, Tara L; Hyman, Bradley T

Synaptic alterations in the rTg4510 mouse model of tauopathy.

rTg4510 小鼠 tau 蛋白病模型中的突触改变

Kopeikina Katherine J, Polydoro Manuela, Tai Hwan-Ching, Yaeger Erich, Carlson George A, Pitstick Rose, Hyman Bradley T, Spires-Jones Tara L

Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets

阿尔茨海默病中tau蛋白病理的传播:新型治疗靶点的鉴定

Pooler, Amy M; Polydoro, Manuela; Wegmann, Susanne; Nicholls, Samantha B; Spires-Jones, Tara L; Hyman, Bradley T

αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

αβγ-突触核蛋白三重敲除小鼠表现出与年龄相关的神经元功能障碍

Greten-Harrison, Becket; Polydoro, Manuela; Morimoto-Tomita, Megumi; Diao, Ling; Williams, Andrew M; Nie, Esther H; Makani, Sachin; Tian, Ning; Castillo, Pablo E; Buchman, Vladimir L; Chandra, Sreeganga S