Poncer相关文献与解析，生知库 | 链接生命科学的每一步

Donneger, Florian; Zanin, Adrien; Besson, Jeremy; Roussel, Delphine; Kadiri, Yoness; Pagan, Carla; Sinha, Manisha; David, Nicolas; Russeau, Marion; Bielle, Franck; Devaux, Bertrand; Mathon, Bertrand; Navarro, Vincent; Chassoux, Francine; Poncer, Jean Christophe

癫痫

神经科学

发表日期：2026

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Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

使用抗衰老药物靶向病理细胞可减少神经发育性 mTOR 相关癫痫的发作

期刊:Nature Neuroscience

影响因子:21.2

doi:10.1038/s41593-024-01634-2

Théo Ribierre, Alexandre Bacq, Florian Donneger, Marion Doladilhe, Marina Maletic, Delphine Roussel, Isabelle Le Roux, Francine Chassoux, Bertrand Devaux, Homa Adle-Biassette, Sarah Ferrand-Sorbets, Georg Dorfmüller, Mathilde Chipaux, Sara Baldassari, Jean-Christophe Poncer, Stéphanie Baulac

Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory

抑制小鼠背侧海马中的KCC2会损害空间记忆和情境记忆。

期刊:Neuropsychopharmacology

影响因子:7.1

doi:10.1038/s41386-022-01480-5

Simonnet, Clémence; Sinha, Manisha; Goutierre, Marie; Moutkine, Imane; Daumas, Stéphanie; Poncer, Jean Christophe

发表日期：2023

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Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons

Gephyrin 与 K-Cl 共转运蛋白 KCC2 相互作用，调节其在皮质神经元中的表面表达和功能

期刊:Journal of Neuroscience

影响因子:4.4

doi:10.1523/JNEUROSCI.2926-20.2021

Sana Al Awabdh, Florian Donneger, Marie Goutierre, Martial Séveno, Oana Vigy, Pauline Weinzettl, Marion Russeau, Imane Moutkine, Sabine Lévi, Philippe Marin, Jean Christophe Poncer

神经

发表日期：2022

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The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function

核氧还蛋白样 2 基因的代谢信号支持大脑功能

期刊:Redox Biology

影响因子:10.7

doi:10.1016/j.redox.2021.102198

Céline Jaillard, Farah Ouechtati, Emmanuelle Clérin, Géraldine Millet-Puel, Mariangela Corsi, Najate Aït-Ali, Frédéric Blond, Quentin Chevy, Lara Gales, Mélissa Farinelli, Deniz Dalkara, José-Alain Sahel, Jean-Charles Portais, Jean-Christophe Poncer, Thierry Léveillard

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity

KCC2 转运和突触活动的相互调节

期刊:Frontiers in Cellular Neuroscience

影响因子:4

doi:10.3389/fncel.2019.00048

Côme, Etienne; Heubl, Martin; Schwartz, Eric J; Poncer, Jean Christophe; Lévi, Sabine

神经科学

发表日期：2019

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GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase

GABAA 受体依赖性突触抑制通过氯离子敏感的 WNK1 激酶快速调节 KCC2 活性。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-017-01749-0

Martin Heubl ,Jinwei Zhang ,Jessica C Pressey ,Sana Al Awabdh ,Marianne Renner ,Ferran Gomez-Castro ,Imane Moutkine ,Emmanuel Eugène ,Marion Russeau ,Kristopher T Kahle ,Jean Christophe Poncer ,Sabine Lévi

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model

Pyk2 调节海马兴奋性突触并导致亨廷顿氏病模型中的认知缺陷

期刊:Nature Communications

影响因子:14.7

doi:10.1038/ncomms15592

Albert Giralt, Veronica Brito, Quentin Chevy, Clémence Simonnet, Yo Otsu, Carmen Cifuentes-Díaz, Benoit de Pins, Renata Coura, Jordi Alberch, Sílvia Ginés, Jean-Christophe Poncer, Jean-Antoine Girault

信号转导

发表日期：2017

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Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration

α-微管蛋白Tuba1a的突变导致微管变得更直，并扰乱神经元迁移

期刊:Journal of Cell Biology

影响因子:7.4

doi:10.1083/jcb.201607074

Richard Belvindrah, Kathiresan Natarajan, Preety Shabajee, Elodie Bruel-Jungerman, Jennifer Bernard, Marie Goutierre, Imane Moutkine, Xavier H Jaglin, Mythili Savariradjane, Theano Irinopoulou, Jean-Christophe Poncer, Carsten Janke, Fiona Francis

神经

发表日期：2017

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KCC2 Gates Activity-Driven AMPA Receptor Traffic through Cofilin Phosphorylation

KCC2通过Cofilin磷酸化调控活性驱动的AMPA受体转运

期刊:Journal of Neuroscience

影响因子:4

doi:10.1523/JNEUROSCI.1735-15.2015

Chevy, Quentin; Heubl, Martin; Goutierre, Marie; Backer, Stéphanie; Moutkine, Imane; Eugène, Emmanuel; Bloch-Gallego, Evelyne; Lévi, Sabine; Poncer, Jean Christophe

Enhancing KCC2 function reduces interictal activity and prevents seizures in temporal lobe epilepsy

增强KCC2功能可减少颞叶癫痫的发作间期活动并预防癫痫发作。

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

使用抗衰老药物靶向病理细胞可减少神经发育性 mTOR 相关癫痫的发作

Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory

抑制小鼠背侧海马中的KCC2会损害空间记忆和情境记忆。

Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons

Gephyrin 与 K-Cl 共转运蛋白 KCC2 相互作用，调节其在皮质神经元中的表面表达和功能

The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function

核氧还蛋白样 2 基因的代谢信号支持大脑功能

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity

KCC2 转运和突触活动的相互调节

GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase

GABAA 受体依赖性突触抑制通过氯离子敏感的 WNK1 激酶快速调节 KCC2 活性。

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model

Pyk2 调节海马兴奋性突触并导致亨廷顿氏病模型中的认知缺陷

Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration

α-微管蛋白Tuba1a的突变导致微管变得更直，并扰乱神经元迁移

KCC2 Gates Activity-Driven AMPA Receptor Traffic through Cofilin Phosphorylation

KCC2通过Cofilin磷酸化调控活性驱动的AMPA受体转运