日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength

TIGIT 破坏可通过增强 TCR 信号强度来挽救低亲和力 TCR 工程化 T 细胞的抗肿瘤活性。

Spiga, Martina; Potenza, Alessia; Magnani, Zulma; Beretta, Stefano; Camisa, Barbara; Conte, Laura; Airaghi, Alessia; Mohammadi, Neda; Perani, Laura; Doglioni, Claudio; Ponzoni, Maurilio; Sanvito, Francesca; Balestrieri, Chiara; Sergi Sergi, Lucia; Botrugno, Oronza A; Giovannoni, Giulio; Tonon, Giovanni; Abbati, Danilo; Iozzi, Chiara; Reichert, Maximilian; Algul, Hana; Pocaterra, Arianna; Fiumara, Martina; Ferrari, Samuele; Ugolini, Alessia; Grometto, Alice; Di Lullo, Giulia; Sitia, Giovanni; Belfiori, Giulio; Protti, Maria Pia; Ostuni, Renato; Mondino, Anna; Reni, Michele; Crippa, Stefano; Falconi, Massimo; Naldini, Luigi; Ruggiero, Eliana; Bonini, Chiara

The investigational anti-B7-H3 antibody-drug conjugate vobramitamab duocarmazine exerts anti-tumor activity in vitro and in vivo in pediatric sarcoma preclinical models.

研究性抗 B7-H3 抗体药物偶联物 vobramitamab duocarmazine 在体外和体内儿科肉瘤临床前模型中均表现出抗肿瘤活性。

Bianchi Giovanna, Pastorino Fabio, Rolandi Gaia, Ciampi Eleonora, Segalerba Daniela, De Giovanni Barbara, Cafferata Barbara, Balbi Matilde, Ravera Silvia, Vellone Valerio Gaetano, Ponzoni Mirco, Brignole Chiara

A 3D lymph node model for chronic lymphocytic leukaemia recapitulates microenvironmental features and drug response in vitro

慢性淋巴细胞白血病的三维淋巴结模型可在体外重现微环境特征和药物反应。

Belloni, Daniela; Barozzi, Dafne; Milani, Giulia; Barbaglio, Federica; Puthukkunnath, Aswin Raj; Ranghetti, Pamela; Perotta, Eleonora; Musco, Teresa; Sampietro, Marta; Ponzoni, Maurilio; Scarfò, Lydia; Ghia, Paolo; Scielzo, Cristina

CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming

CD4+ T细胞激活库普弗细胞,从而逆转肝细胞启动引起的CD8+ T细胞功能障碍

Valentina Venzin #,Cristian G Beccaria #,Chiara Perucchini,Pietro Delfino,Elisa B Bono,Leonardo Giustini,Federica Moalli,Marta Grillo,Valeria Fumagalli,Chiara Laura ,Pietro Di Lucia,Katharina Reinhard,Jutta Petschenka,Tana Annmarie Omokoko,Anna Celant,Sabrina Ottolini,Keigo Kawashima,Micol Ravà,Marco De Giovanni,Donato Inverso,Mirela Kuka,Patrick T F Kennedy,Martin Guilliams,Giulia Casorati,Federica Pedica,Maurilio Ponzoni,Uğur Şahin,Nina Le Bert,Antonio Bertoletti,Fulvia Vascotto,Luca G Guidotti,Matteo Iannacone

CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming

CD4+ T细胞激活库普弗细胞,从而逆转肝细胞启动引起的CD8+ T细胞功能障碍

Valentina Venzin # ,Cristian G Beccaria # ,Chiara Perucchini ,Pietro Delfino ,Elisa B Bono ,Leonardo Giustini ,Federica Moalli ,Marta Grillo ,Valeria Fumagalli ,Chiara Laura ,Pietro Di Lucia ,Katharina Reinhard ,Jutta Petschenka ,Tana Annmarie Omokoko ,Anna Celant ,Sabrina Ottolini ,Keigo Kawashima ,Micol Ravà ,Marco De Giovanni ,Donato Inverso ,Mirela Kuka ,Patrick T F Kennedy ,Martin Guilliams ,Giulia Casorati ,Federica Pedica ,Maurilio Ponzoni ,Uğur Şahin ,Nina Le Bert ,Antonio Bertoletti ,Fulvia Vascotto ,Luca G Guidotti ,Matteo Iannacone

Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone

侵袭性B细胞淋巴瘤保留了ATR依赖性决定因子,这些决定因子可将T细胞排除在生发中心暗区之外。

Cancila, Valeria; Bertolazzi, Giorgio; Chan, Allison Sy; Medico, Giovanni; Bastianello, Giulia; Morello, Gaia; Paysan, Daniel; Lai, Clemence; Hong, Liang; Shenoy, Girija; Jaynes, Patrick W; Schiavoni, Giovanna; Mattei, Fabrizio; Piconese, Silvia; Revuelta, Maria V; Noto, Francesco; Businaro, Luca; De Ninno, Adele; Cammarata, Ilenia; Pagni, Fabio; Venkatachalapathy, Saradha; Sangaletti, Sabina; Di Napoli, Arianna; Cicio, Giada; Vacca, Davide; Lonardi, Silvia; Lorenzi, Luisa; Ferreri, Andrés Jm; Belmonte, Beatrice; Liu, Min; Lakshmanan, Manikandan; Ong, Michelle Sn; Zhang, Biyan; See, Tingyi; Lam, Kong-Peng; Varano, Gabriele; Colombo, Mario P; Bicciato, Silvio; Inghirami, Giorgio; Cerchietti, Leandro; Ponzoni, Maurilio; Zappasodi, Roberta; Metzger, Evelyn; Beechem, Joseph; Facchetti, Fabio; Foiani, Marco; Casola, Stefano; Jeyasekharan, Anand D; Tripodo, Claudio

A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities

患者来源的T细胞淋巴瘤生物样本库揭示了发病机制和宿主相关的治疗弱点。

Danilo Fiore,Luca Vincenzo Cappelli,Liu Zhaoqi,Nikita Kotlov,Maria Sorokina,Jude Phillip,Paul Zumbo,Liron Yoffe,Paola Ghione,Anqi Wang,Xueshuai Han,Abigail Taylor,William Chiu,Valentina Fragliasso,Fabrizio Tabbo,Nahuel Zamponi,Nicolás Di Siervi,Clarisse Kayembe,Giovanni Medico,Ruchi P Patel,Marcello Gaudiano,Rodolfo Machiorlatti,Giuseppina Astone,Maria Teresa Cacciapuoti,Giorgia Zanetti,Claudia Pignataro,Ruiz Arvin Eric,Sanjay Patel,Francesca Zammarchi,Claudio Zanettini,Lucio Queiroz,Anastasia Nikitina,Olga Kudryashova,Anton Karelin,Daniil Nikitin,Dmitry Tychinin,Ekaterina Postovalova,Alexander Bagaev,Viktor Svekolkin,Ekaterina Belova,Katerina Tikhonova,Sandrine Degryse,Chengqi Xu,Domenico Novero,Maurilio Ponzoni,Enrico Tiacci,Brunangelo Falini,Joo Song,Inna Khodos,Elisa De Stanchina,Gabriele Macari,Luciana Cafforio,Simone Gardini,Roberto Piva,Enzo Medico,Samuel Y Ng,Allison Moskowitz,Zachary Epstein,Andrew Intlekofer,Dogan Ahmed,Wing C Chan,Peter Martin,Jia Ruan,Francesco Bertoni,Robin Foà,Joshua D Brody,David M Weinstock,Jaspreet Osan,Laura Santambrogio,Oliver Elemento,Doron Betel,Wayne Tam,Marco Ruella,Leandro Cerchietti,Raul Rabadan,Steven Horwitz,Giorgio Inghirami

A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities

患者来源的T细胞淋巴瘤生物样本库揭示了发病机制和宿主相关的治疗弱点。

Danilo Fiore ,Luca Vincenzo Cappelli ,Liu Zhaoqi ,Nikita Kotlov ,Maria Sorokina ,Jude Phillip ,Paul Zumbo ,Liron Yoffe ,Paola Ghione ,Anqi Wang ,Xueshuai Han ,Abigail Taylor ,William Chiu ,Valentina Fragliasso ,Fabrizio Tabbo ,Nahuel Zamponi ,Nicolás Di Siervi ,Clarisse Kayembe ,Giovanni Medico ,Ruchi P Patel ,Marcello Gaudiano ,Rodolfo Machiorlatti ,Giuseppina Astone ,Maria Teresa Cacciapuoti ,Giorgia Zanetti ,Claudia Pignataro ,Ruiz Arvin Eric ,Sanjay Patel ,Francesca Zammarchi ,Claudio Zanettini ,Lucio Queiroz ,Anastasia Nikitina ,Olga Kudryashova ,Anton Karelin ,Daniil Nikitin ,Dmitry Tychinin ,Ekaterina Postovalova ,Alexander Bagaev ,Viktor Svekolkin ,Ekaterina Belova ,Katerina Tikhonova ,Sandrine Degryse ,Chengqi Xu ,Domenico Novero ,Maurilio Ponzoni ,Enrico Tiacci ,Brunangelo Falini ,Joo Song ,Inna Khodos ,Elisa De Stanchina ,Gabriele Macari ,Luciana Cafforio ,Simone Gardini ,Roberto Piva ,Enzo Medico ,Samuel Y Ng ,Allison Moskowitz ,Zachary Epstein ,Andrew Intlekofer ,Dogan Ahmed ,Wing C Chan ,Peter Martin ,Jia Ruan ,Francesco Bertoni ,Robin Foà ,Joshua D Brody ,David M Weinstock ,Jaspreet Osan ,Laura Santambrogio ,Oliver Elemento ,Doron Betel ,Wayne Tam ,Marco Ruella ,Leandro Cerchietti ,Raul Rabadan ,Steven Horwitz ,Giorgio Inghirami

B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements

B细胞受体沉默揭示了具有MYC和BCL2重排的高级别B细胞淋巴瘤的起源和依赖性

Gabriele Varano #,Silvia Lonardi #,Paola Sindaco #,Ilaria Pietrini #,Gaia Morello,Piera Balzarini,Filippo Vit,Hadas Neuman,Giorgio Bertolazzi,Silvia Brambillasca,Nicara C Parr,Marco Chiarini,Silvia Bellesi,Elena Maiolo,Sabrina Giampaolo,Federica Mainoldi,Viveka Selvarasa,Hiroshi Arima,Vilma Pellegrini,Chiara Pagani,Mattia Bugatti,Cecilia Ranise,Tommaso M Taddei,Takashi Sonoki,Hajdica Thanasi,Elena Morlacchi,Daniel Segura-Garzon,Emma Albertini,Rosa Daffini,Anojan Sivacegaram,Henry Yang,Ying Li,Valeria Cancila,Giada Cicio,Michela Robusto,Brian Leuzzi,Adrian Andronache,Paolo Trifiro,Mirko Riboni,Simone P Minardi,Raoul J P Bonnal,Cristina Lopez Gonzalez,Euplio Visco,Pasquale Capaccio,Sara Torretta,Lorenzo Pignataro,Camillo Almici,Mario Varasi,Luigi M Larocca,Reiner Siebert,Brunangelo Falini,Andres J M Ferreri,Alessandra Tucci,Daniele Lorenzini,Antonello D Cabras,Giancarlo Pruneri,Arianna Di Napoli,Marco Ungari,Marco Pizzi,Stefan Hohaus,Ciro Mercurio,Joo Y Song,Wing C Chan,Luisa Lorenzi,Riccardo Bomben,Maurilio Ponzoni,Ramit Mehr,Claudio Tripodo #,Fabio Facchetti #,Stefano Casola #

Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome.

Shank3 通过 mGlu5 调节 Rpl3 表达和蛋白质合成:对 Phelan McDermid 综合征的意义

Giona Federica, Beretta Stefania, Zippo Antonio, Stefanoni Alessia, Tomasoni Zaira, Vicidomini Cinzia, Ponzoni Luisa, Sala Mariaelvina, Jones Carrie K, Conn P Jeffrey, Boeckers Tobias M, Sala Carlo, Verpelli Chiara