日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

16p11.2 缺失与人类 iPSC 衍生的多巴胺能神经元网络过度活跃有关,可通过体外 RHOA 抑制来挽救

Maria Sundberg, Hannah Pinson #, Richard S Smith #, Kellen D Winden, Pooja Venugopal, Derek J C Tai, James F Gusella, Michael E Talkowski, Christopher A Walsh, Max Tegmark, Mustafa Sahin

Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

TSC 缺陷型神经元的表型筛选揭示了热休克机制是 mTORC1 和纤毛减少的可用药物途径

Alessia Di Nardo, Isadora Lenoël, Kellen D Winden, Alina Rühmkorf, Meera E Modi, Lee Barrett, Ebru Ercan-Herbst, Pooja Venugopal, Robert Behne, Carla A M Lopes, Robin J Kleiman, Mónica Bettencourt-Dias, Mustafa Sahin