日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS.

轴突 Eif5a 低磷化控制局部翻译,减轻 FUS-ALS 的缺陷。

Piol Diana, Khalil Bilal, Robberechts Tessa, Killian Theo, Georgopoulou Maria, Partel Gabriele, Wouters David, Hecker Nikolai, Tziortzouda Paraskevi, Verresen Yana, Corthout Nikky, Kint Sam, Vandereyken Katy, Van Damme Philip, Voet Thierry, Davie Kristofer, Poovathingal Suresh, Van Den Bosch Ludo, Aerts Stein, Sifrim Alejandro, Da Cruz Sandrine

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

阿尔茨海默病治疗药物Lecanemab通过诱导小胶质细胞中的淀粉样蛋白清除程序来减轻Aβ病理。

Albertini Giulia, Zielonka Magdalena, Cuypers Marie-Lynn, Snellinx An, Xu Ciana, Poovathingal Suresh, Wojno Marta, Davie Kristofer, van Lieshout Veerle, Craessaerts Katleen, Wolfs Leen, Pasciuto Emanuela, Jaspers Tom, Horré Katrien, Serneels Lurgarde, Fiers Mark, Dewilde Maarten, De Strooper Bart

Evaluating single-cell ATAC-seq atlasing technologies using sequence-to-function modeling

利用序列-功能模型评估单细胞ATAC-seq图谱技术

Dickmänken, Hannah; Wojno, Marta; Mahieu, Lukas; Theunis, Koen; Ekşi, Eren Can; Christiaens, Valerie; Kempynck, Niklas; De Rop, Florian V; Roels, Natalie; Spanier, Katina I; Vandepoel, Roel; Hulselmans, Gert; Poovathingal, Suresh; Aerts, Stein

Human Myelin Spheres for in Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling.

用于体外少突胶质细胞成熟、髓鞘形成和神经系统疾病建模的人类髓鞘球。

Ahuja Karan, Ramezankhani Roya, Wang Xinyu, Burg Thibaut, Amos Giulia, Neyrinck Katrien, Silva Alessio, Arekatla Geethika, Cassidy Eleanor Eva, Nami Fatemeharefeh, Terryn Joke, Wierda Keimpe, Vints Katlijn, Vandamme Niels, Poovathingal Suresh, Lambrichts Ivo, Swinnen Johannes V, Van Den Bosch Ludo, De Groef Lies, Moons Lieve, Verfaillie Catherine, Neyts Johan, Jochmans Dirk, Chai Yoke Chin

C9orf72 hexanucleotide repeat expansions impair microglial response in ALS.

C9orf72 六核苷酸重复序列扩增会损害 ALS 中的小胶质细胞反应。

Masrori Pegah, Bijnens Baukje, Fumagalli Laura, Davie Kristofer, Poovathingal Suresh Kumar, Meese Tim, Storm Annet, Hersmus Nicole, Fazal Raheem, van den Biggelaar Diede, Asselbergh Bob, Gruel Roxane, Van Den Daele Johanna, Denton Heidi, Miquel Paula Polanco, Manzella Simona, De Vos Winnok H, Chandran Siddhartan, Van Den Bosch Ludo, Thal Dietmar Rudolf, Mancuso Renzo, Van Damme Philip

Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits.

成年小胶质细胞的细胞骨架控制对于恢复神经发育突触和认知缺陷至关重要

Kessels Sofie, Trippaers Chloë, Mertens Melanie, Hamad Ibrahim, Rombaut Ben, Janssen Art, Ramanathan Keerthana, Duwé Sam, Gharghani Adelaïde M, Theuwis Rune, Delbroek Amber, Vangansewinkel Tim, Berden Lisa, Beeken Jolien, Vandormael Patrick, Poovathingal Suresh, Voets Thomas, Kleinewietfeld Markus, Nguyen Laurent, Antel Jack P, Healy Luke M, Cowley Sally A, Ishizuka Koko, Rigo Jean-Michel, Hendrix Jelle, Vanmierlo Tim, Dewachter Ilse, Alpizar Yeranddy A, Sawa Akira, Brône Bert

A dynamic gene regulatory code drives synaptic development of hippocampal granule cells

动态基因调控密码驱动海马颗粒细胞突触的发育

Blanca Lorente-Echeverría ,Danie Daaboul ,Jeroen Vandensteen ,Gabriele Marcassa ,Willem Naert ,Joris Vandenbempt ,Elke Leysen ,Malou Reverendo ,Ine Vlaeminck ,Lise Vervloessem ,Jochen Lamote ,Suresh Poovathingal ,Kristofer Davie ,Keimpe Wierda ,Dan Dascenco ,Stein Aerts ,Joris de Wit

APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodegeneration (N), halting progressive ATN pathology in a preclinical model

APOE 缺陷抑制淀粉样蛋白促进的 tau 蛋白病理 (T) 和神经退行性变 (N),从而在临床前模型中阻止进行性 ATN 病理的发生。

Sarah Vanherle # ,Art Janssen # ,Manuel Gutiérrez de Ravé # ,Bieke Janssen ,Chritica Lodder ,Pablo Botella Lucena ,Sofie Kessels ,Jana Hardy ,Eline Vandeput ,Yanyan Wang ,Ilie-Cosmin Stancu ,Andrei Segal ,Markus Kleinewietfeld ,Thomas Voets ,Bert Brône ,Suresh Poovathingal ,Yeranddy A Alpizar ,Ilse Dewachter

Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across five fly Parkinsonism models.

胆碱能投射神经元的突触失调导致五种果蝇帕金森病模型出现嗅觉功能障碍

Pech Ulrike, Janssens Jasper, Schoovaerts Nils, Kuenen Sabine, Calatayud Aristoy Carles, Gallego Sandra F, Makhzami Samira, Hulselmans Gert J, Poovathingal Suresh, Davie Kristofer, Bademosi Adekunle T, Swerts Jef, Vilain Sven, Aerts Stein, Verstreken Patrik

Systematic benchmarking of single-cell ATAC-sequencing protocols

单细胞ATAC测序方案的系统性基准测试

Florian V De Rop ,Gert Hulselmans ,Chris Flerin ,Paula Soler-Vila ,Albert Rafels ,Valerie Christiaens ,Carmen Bravo González-Blas ,Domenica Marchese ,Ginevra Caratù ,Suresh Poovathingal ,Orit Rozenblatt-Rosen ,Michael Slyper ,Wendy Luo ,Christoph Muus ,Fabiana Duarte ,Rojesh Shrestha ,S Tansu Bagdatli ,M Ryan Corces ,Lira Mamanova ,Andrew Knights ,Kerstin B Meyer ,Ryan Mulqueen ,Akram Taherinasab ,Patrick Maschmeyer ,Jörn Pezoldt ,Camille Lucie Germaine Lambert ,Marta Iglesias ,Sebastián R Najle ,Zain Y Dossani ,Luciano G Martelotto ,Zach Burkett ,Ronald Lebofsky ,José Ignacio Martin-Subero ,Satish Pillai ,Arnau Sebé-Pedrós ,Bart Deplancke ,Sarah A Teichmann ,Leif S Ludwig ,Theodore P Braun ,Andrew C Adey ,William J Greenleaf ,Jason D Buenrostro ,Aviv Regev ,Stein Aerts ,Holger Heyn