文献库，生知库 | 链接生命科学的每一步

日期影响因子

Bispecific receptor decoy proteins block ocular neovascularization via simultaneous blockade of vascular endothelial growth factor A and C

双特异性受体诱饵蛋白通过同时阻断血管内皮生长因子A和C来抑制眼部新生血管形成。

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2025.03.027

Sargunas, Paul R; Ariail, Emily; Lima E Silva, Raquel; Patil, Akash; Zhang, Mingliang; Shen, Jikui; Lopes, Beatriz Silva; Oh, Yuseong; McCue, Amelia C; Ramasubramanian, Ranjani; Stephenson, A Carson; Popel, Aleksander S; Campochiaro, Peter A; Spangler, Jamie B

发表日期：2025

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Bi-level graph learning unveils prognosis-relevant tumor microenvironment patterns in breast multiplexed digital pathology

双层图学习揭示乳腺多重数字病理中与预后相关的肿瘤微环境模式

期刊:Patterns

影响因子:7.4

doi:10.1016/j.patter.2025.101178

Wang, Zhenzhen; Santa-Maria, Cesar A; Popel, Aleksander S; Sulam, Jeremias

肿瘤微环境

发表日期：2025

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Spatial Architecture of Single-Cell and Vasculature in Tumor Microenvironment Predicts Clinical Outcomes in Triple-Negative Breast Cancer

肿瘤微环境中单细胞和血管的空间结构可预测三阴性乳腺癌的临床结果

期刊:Modern Pathology

影响因子:5.5

doi:10.1016/j.modpat.2024.100652

Mi, Haoyang; Varadhan, Ravi; Cimino-Mathews, Ashley M; Emens, Leisha A; Santa-Maria, Cesar A; Popel, Aleksander S

细胞生物学

肿瘤微环境

发表日期：2025

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Promoting vascular stability through Src inhibition and Tie2 activation: A model-based analysis

通过抑制Src和激活Tie2促进血管稳定性：基于模型的分析

期刊:iScience

影响因子:4.1

doi:10.1016/j.isci.2025.112625

Zhang, Yu; Kontos, Christopher D; Annex, Brian H; Popel, Aleksander S

发表日期：2025

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A mechanistic computational model of HGF-VEGF-mediated endothelial cell proliferation and vascular permeability.

HGF-VEGF介导的内皮细胞增殖和血管通透性的机制计算模型

期刊:iScience

影响因子:4.1

doi:10.1016/j.isci.2025.113199

de Melo Oliveira Rebeca Hannah, Patil Akash, Annex Brian H, Pathak Arvind P, Popel Aleksander S

细胞生物学

发表日期：2025

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Experimental and computational studies of IL-6 signaling in endothelial cells under hypoxia serum starvation conditions

在缺氧血清饥饿条件下，对内皮细胞中IL-6信号传导进行实验和计算研究

期刊:Cytokine

影响因子:3.7

doi:10.1016/j.cyto.2025.157029

Song, Min; Wang, Youli; Annex, Brian H; Popel, Aleksander S

细胞生物学

发表日期：2025

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Quantitative Calibration of a Spatial QSP Model Identifies Fibroblast Impact on HCC Immunotherapy

空间QSP模型的定量校准揭示成纤维细胞对肝细胞癌免疫治疗的影响

doi:10.1101/2025.10.31.685939

Zhang, Shuming; Wang, Hanwen; Cho, Yeonju; Wong, Wendy; Yarchoan, Mark; Jaffee, Elizabeth M; Ho, Won Jin; Kagohara, Luciane T; Fertig, Elana J; Popel, Aleksander S; Deshpande, Atul

免疫/内分泌

成纤维细胞

细胞生物学

发表日期：2025

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Oncolytic peptide NF27 effectively inhibits tumor growth and eradicates tumors in multiple cancer types

溶瘤肽NF27能有效抑制肿瘤生长并根除多种癌症类型的肿瘤。

doi:10.1101/2025.08.17.668569

Furukawa, Natsuki; Chao, Alex R; Yang, Wendy; Patil, Akash; Christenson, Eric S; Mirando, Adam C; Pandey, Niranjan B; Popel, Aleksander S

发表日期：2025

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Quantitative Systems Pharmacology Modeling in Immuno-Oncology: Hypothesis Testing, Dose Optimization, and Efficacy Prediction

免疫肿瘤学中的定量系统药理学建模：假设检验、剂量优化和疗效预测

期刊:Handbook of Experimental Pharmacology

doi:10.1007/164_2024_735

Wang, Hanwen; Arulraj, Theinmozhi; Ippolito, Alberto; Popel, Aleksander S

免疫/内分泌

发表日期：2025

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Correction: Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers

更正：胰腺导管腺癌免疫细胞群的定量空间分析揭示肿瘤微环境异质性和预后生物标志物

期刊:Cancer Research

影响因子:16.6

doi:10.1158/0008-5472.CAN-24-2929

Mi, Haoyang; Sivagnanam, Shamilene; Betts, Courtney B; Liudahl, Shannon M; Jaffee, Elizabeth M; Coussens, Lisa M; Popel, Aleksander S

肿瘤微环境

细胞生物学

免疫/内分泌

发表日期：2024

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