The catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease action
催化天冬氨酸在胰蛋白酶和体外进化的底物样抑制剂之间形成的 Michaelis 复合物中被质子化:丝氨酸蛋白酶作用的精细机制
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M110.161604
Weixiao Yuan Wahlgren, Gábor Pál, József Kardos, Pálma Porrogi, Borbála Szenthe, András Patthy, László Gráf, Gergely Katona