日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

从人外周血中鉴定出与1型糖尿病相关的T细胞受体库特征

Rawat, Puneet; Shapiro, Melanie R; Peters, Leeana D; Widrich, Michael; Mayer-Blackwell, Koshlan; Motwani, Keshav; Pavlović, Milena; Al Hajj, Ghadi; Posgai, Amanda L; Kanduri, Chakravarthi; Isacchini, Giulio; Chernigovskaya, Maria; Scheffer, Lonneke; Motwani, Kartik; Balzano-Nogueira, Leandro Octavio; Pettenger-Willey, Camryn M; Valkiers, Sebastiaan; Jacobsen, Laura M; Haller, Michael J; Schatz, Desmond A; Wasserfall, Clive H; Emerson, Ryan O; Fiore-Gartland, Andrew J; Atkinson, Mark A; Klambauer, Günter; Sandve, Geir Kjetil; Greiff, Victor; Brusko, Todd M

TCR2HLA: Calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes

TCR2HLA:通过对TCR库进行校准推断HLA基因型,可以识别具有免疫学意义的元克隆型。

Mayer-Blackwell, Koshlan; Minervina, Anastasia; Pogorelyy, Mikhail; Rawat, Puneet; Shapiro, Melanie R; Peters, Leeana D; Ford, Emily S; Posgai, Amanda L; Vegesana, Kasi; Minot, Samuel; Koelle, David M; Greiff, Victor; Bradley, Philip; Brusko, Todd M; Thomas, Paul G; Fiore-Gartland, Andrew

Aberrant immune regulation and enrichment of stem-like CD8(+) T cells in the pancreatic lymph node during type 1 diabetes development

1型糖尿病发展过程中胰腺淋巴结内异常的免疫调节和干细胞样CD8(+) T细胞的富集

Peters, Leeana D; Seay, Howard R; Smith, Justin; Posgai, Amanda L; Berkowitz, Reed; Wasserfall, Clive H; Atkinson, Mark A; Bacher, Rhonda; Brusko, Maigan A; Brusko, Todd M

The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium

AIRR 数据共享平台中的 1 型糖尿病 T 细胞受体和 B 细胞受体库:通过 1 型糖尿病 AIRR 联盟访问、使用和贡献的实用指南

Hanna, Stephanie J; Bonami, Rachel H; Corrie, Brian; Westley, Monica; Posgai, Amanda L; Luning Prak, Eline T; Breden, Felix; Michels, Aaron W; Brusko, Todd M

Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes

利用人工智能和机器学习加速发现1型糖尿病的疾病改善疗法

Shapiro, Melanie R; Tallon, Erin M; Brown, Matthew E; Posgai, Amanda L; Clements, Mark A; Brusko, Todd M

The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes

型糖尿病患者的胰腺:从糖尿病胰腺器官捐献者网络中汲取的经验教训

Kusmartseva, Irina; Posgai, Amanda; Yang, Mingder; Oram, Richard; Atkinson, Mark; Pugliese, Alberto; Evans-Molina, Carmella

Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function

抑制 CD226 共刺激可通过增强调节性 T 细胞和削弱效应性 T 细胞功能来抑制 NOD 小鼠的糖尿病发展

Matthew E Brown #, Puchong Thirawatananond #, Leeana D Peters, Elizabeth J Kern, Sonali Vijay, Lindsey K Sachs, Amanda L Posgai, Maigan A Brusko, Melanie R Shapiro, Clayton E Mathews, Rhonda Bacher, Todd M Brusko

The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes

型糖尿病心血管疾病数据库 (CaRe-T1D):美国国立糖尿病、消化和肾脏疾病研究所 (NIDDK) 的一项旨在增进对 1 型糖尿病与 2 型糖尿病心血管疾病潜在机制理解的计划

Jones, Teresa L Z; Kusmartseva, Irina; Litovsky, Silvio; Thakar, Rahul; Posgai, Amanda L; Eckel, Robert H; Atkinson, Mark A

Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes

1型糖尿病中,胰岛素阳性细胞簇的丢失先于胰岛细胞数量和β细胞面积的减少。

Drotar, Denise M; Vazquez Ramos, Giovanni J A; Williams, MacKenzie D; David, Surya T; Luce, Caitlyn; Smith, Justin A; Posgai, Amanda L; Bacher, Rhonda; Campbell-Thompson, Martha; Kusmartseva, Irina; Brusko, Maigan A; Atkinson, Mark A; Wasserfall, Clive H

Serological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes

胰腺外分泌功能的血清学标志物在区分进展为 1 型糖尿病的个体方面具有不同的参考价值。

Williams, MacKenzie D; Grace, Catherine Ramsey; Posgai, Amanda L; McGrail, Kieran M; Brusko, Maigan A; Haller, Michael J; Jacobsen, Laura; Schatz, Desmond; Brusko, Todd M; Atkinson, Mark; Bacher, Rhonda; Wasserfall, Clive H