日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans

α-突触核蛋白病对小鼠和人类的多用途 DNA 修复/氧化还原蛋白 APE1 产生性别二态性影响

Kristin M Miner, Anuj S Jamenis, Tarun N Bhatia, Rachel N Clark, Dhivyaa Rajasundaram, Sylvie Sauvaigo, Daniel M Mason, Jessica M Posimo, Nevil Abraham, Brett A DeMarco, Xiaoming Hu, R Anne Stetler, Jun Chen, Laurie H Sanders, Kelvin C Luk, Rehana K Leak

BRAFV600E-Driven Lung Adenocarcinoma Requires Copper to Sustain Autophagic Signaling and Processing

BRAFV600E驱动的肺腺癌需要铜来维持自噬信号传导和加工过程。

Tiffany Tsang # ,Xingxing Gu # ,Caroline I Davis ,Jessica M Posimo ,Zoey A Miller ,Donita C Brady

Loss of p19Arf promotes fibroblast survival during leucine deprivation

p19Arf 的缺失促进亮氨酸缺乏期间成纤维细胞的存活

Kerry C Roby, Allyson Lieberman, Bang-Jin Kim, Nicole Zaragoza Rodríguez, Jessica M Posimo, Tiffany Tsang, Ioannis I Verginadis, Ellen Puré, Donita C Brady, Constantinos Koumenis, Sandra Ryeom

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

铜是自噬激酶 ULK1/2 的重要调节剂,可促进肺腺癌的发生

Tiffany Tsang #, Jessica M Posimo #, Andrea A Gudiel, Michelle Cicchini, David M Feldser, Donita C Brady

Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma

抑制 BCL2 家族成员可提高铜螯合疗法在 BRAFV600E 驱动的黑色素瘤中的疗效

Ye-Jin Kim ,Tiffany Tsang ,Gray R Anderson ,Jessica M Posimo ,Donita C Brady

CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation

CDK7抑制剂通过MED1失活抑制去势抵抗性前列腺癌

Reyaz Ur Rasool ,Ramakrishnan Natesan ,Qu Deng ,Shweta Aras ,Priti Lal ,Samuel Sander Effron ,Erick Mitchell-Velasquez ,Jessica M Posimo ,Shannon Carskadon ,Sylvan C Baca ,Mark M Pomerantz ,Javed Siddiqui ,Lauren E Schwartz ,Daniel J Lee ,Nallasivam Palanisamy ,Goutham Narla ,Robert B Den ,Matthew L Freedman ,Donita C Brady ,Irfan A Asangani

Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism

基于活性比率的FRET探针揭示了由谷胱甘肽代谢改变引起的癌基因驱动的不稳定铜池的变化

Chung, Clive Yik-Sham; Posimo, Jessica M; Lee, Sumin; Tsang, Tiffany; Davis, Julianne M; Brady, Donita C; Chang, Christopher J

Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma

铜伴侣 ATOX1 是 BRAF 突变阳性黑色素瘤中 MAPK 信号传导和生长所必需的

Ye-Jin Kim, Gavin J Bond, Tiffany Tsang, Jessica M Posimo, Luca Busino, Donita C Brady

YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma

YAP1 增强 NF-κB 对肉瘤中时钟介导的未折叠蛋白反应和自噬的依赖性和独立性影响

Adrian Rivera-Reyes, Shuai Ye, Gloria E Marino, Shaun Egolf, Gabrielle E Ciotti, Susan Chor, Ying Liu, Jessica M Posimo, Paul M C Park, Koreana Pak, Yael Babichev, Jaimarie Sostre-Colón, Feven Tameire, Nektaria Maria Leli, Constantinos Koumenis, Donita C Brady, Anthony Mancuso, Kristy Weber, Rebecca

Astrocytes Surviving Severe Stress Can Still Protect Neighboring Neurons from Proteotoxic Injury

星形胶质细胞在严重压力下仍能保护邻近的神经元免受蛋白毒性损伤

Amanda M Gleixner, Jessica M Posimo, Deepti B Pant, Matthew P Henderson, Rehana K Leak