日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes

开发一种新型苯二氮卓类药物以阐明内脏疼痛综合征中的外周GABA-A信号传导机制

Poslusney, Michael S; Li, Qian; Buchler, Ingrid P; Huang, Yifang; Liu, Liansheng; Zhu, Yaohui; Kulkarni, Subhash; Carr, Gregory; DeBrosse, Adrienne; White, Noelle; Peters, Diane; Barrow, James C; Pasricha, Pankaj J

Clinical recommendations for polygenic risk score-enhanced breast cancer screening: Can.Heal project

基于多基因风险评分的乳腺癌筛查临床建议:Can.Heal 项目

Bubser, Michael; Bridges, Thomas M; Dencker, Ditte; Gould, Robert W; Grannan, Michael; Noetzel, Meredith J; Lamsal, Atin; Niswender, Colleen M; Daniels, J Scott; Poslusney, Michael S; Melancon, Bruce J; Tarr, James C; Byers, Frank W; Wess, Jürgen; Duggan, Mark E; Dunlop, John; Wood, Michael W; Brandon, Nicholas J; Wood, Michael R; Lindsley, Craig W; Conn, P Jeffrey; Jones, Carrie K; Taha, A; Matt McCrary, J; van Rooij, J; Lahousse, L; Paoletti, F; Pascucci, E; Vaht, M; Pastorino, R; Pezzullo, A M; Boccia, S

Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O-Methyltransferase

双环羟基吡啶酮类化合物的合成及作为儿茶酚O-甲基转移酶抑制剂的评价

Ernst, Glen; Akuma, Daniel; Au, Vinh; Buchler, Ingrid P; Byers, Spencer; Carr, Gregory V; Defays, Sabine; de León, Pablo; Demaude, Thierry; DePasquale, Michael; Durieu, Véronique; Huang, Yifang; Jigorel, Emilie; Kimos, Martha; Kolobova, Anna; Montel, Florian; Moureau, Florence; Poslusney, Michael; Swinnen, Dominique; Vandergeten, Marie-Christine; Van Houtvin, Nathalie; Wei, Huijun; White, Noelle; Wood, Martyn; Barrow, James C

Novel M(4) positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

通过质疑β-氨基羧酰胺配体中假定的分子内氢键基序的作用和影响,开发出新型M(4)正变构调节剂

Poslusney, Michael S; Salovich, James M; Wood, Michael R; Melancon, Bruce J; Bollinger, Katrina A; Luscombe, Vincent B; Rodriguez, Alice L; Engers, Darren W; Bridges, Thomas M; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M(4) PAMs

受醛氧化酶 (AO) 代谢启发的 SAR 研究:新型中枢神经系统穿透性三环 M(4) PAM 的发现

Chopko, Trevor C; Han, Changho; Gregro, Alison R; Engers, Darren W; Felts, Andrew S; Poslusney, Mike S; Bollinger, Katrina A; Morrison, Ryan D; Bubser, Michael; Lamsal, Atin; Luscombe, Vincent B; Cho, Hyekyung P; Schnetz-Boutaud, Nathalie C; Rodriguez, Alice L; Chang, Sichen; Daniels, J Scott; Stec, Donald F; Niswender, Colleen M; Jones, Carrie K; Wood, Michael R; Wood, Michael W; Duggan, Mark E; Brandon, Nicholas J; Conn, P Jeffrey; Bridges, Thomas M; Lindsley, Craig W; Melancon, Bruce J

Challenges in the development of an M(4) PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

M(4) PAM 体内工具化合物开发面临的挑战:VU0467154 的发现及其近缘类似物出乎意料的 DMPK 特征

Wood, Michael R; Noetzel, Meredith J; Poslusney, Michael S; Melancon, Bruce J; Tarr, James C; Lamsal, Atin; Chang, Sichen; Luscombe, Vincent B; Weiner, Rebecca L; Cho, Hyekyung P; Bubser, Michael; Jones, Carrie K; Niswender, Colleen M; Wood, Michael W; Engers, Darren W; Brandon, Nicholas J; Duggan, Mark E; Conn, P Jeffrey; Bridges, Thomas M; Lindsley, Craig W

Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

发现 VU0467485/AZ13713945:一种被评估为治疗精神分裂症的临床前候选药物的 M4 PAM

Michael R Wood, Meredith J Noetzel, Bruce J Melancon, Michael S Poslusney, Kellie D Nance, Miguel A Hurtado, Vincent B Luscombe, Rebecca L Weiner, Alice L Rodriguez, Atin Lamsal, Sichen Chang, Michael Bubser, Anna L Blobaum, Darren W Engers, Colleen M Niswender, Carrie K Jones, Nicholas J Brandon, M

Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule

将靛红取代应用于高选择性毒蕈碱M1 PAM ML137:MLPCN探针分子的持续优化

Melancon, Bruce J; Poslusney, Michael S; Gentry, Patrick R; Tarr, James C; Sheffler, Douglas J; Mattmann, Margrith E; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R

Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule

高选择性毒蕈碱M1 PAM ML137中异靛红的螺环取代:MLPCN探针分子的持续优化

Poslusney, Michael S; Melancon, Bruce J; Gentry, Patrick R; Sheffler, Douglas J; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R

Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists

一系列新型二芳基酰胺M₁拮抗剂的合成及生物学表征

Poslusney, Michael S; Sevel, Christian; Utley, Thomas J; Bridges, Thomas M; Morrison, Ryan D; Kett, Nathan R; Sheffler, Douglas J; Niswender, Colleen M; Daniels, J S; Conn, P J; Lindsley, Craig W; Wood, Michael R