日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Comprehensive perturbation of transcription factors in human cardiomyocytes reveals the regulatory architecture of congenital heart disease

对人类心肌细胞中转录因子的全面扰动揭示了先天性心脏病的调控结构

Takeuchi, Chikara; Sivakumar, Sushama; Sundarrajan, Anjana; Wang, Yihan; Goetsch, Sean C; Zhao, Huan; Wang, Lei; Nzima, Mpathi; Deng, Minnie; Kulkarni, Kartik N; Xu, Lin; Wu, Jun; Posner, Bruce A; Chahrour, Maria H; Kraus, W Lee; Munshi, Nikhil V; Hon, Gary C

Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS).

通过高通量筛选 (HTS) 鉴定针对孤立性纤维瘤 (SFT) 的 BET 抑制剂 (BETi)。

Mondaza-Hernandez Jose L, Moura David S, Li Yi, Marti Jesus L, Gomez-Puertas Paulino, Nguyen John T, Wei Shuguang, Posner Bruce A, Meyer Clark A, Bleris Leonidas, Martin-Broto Javier, Hayenga Heather N

Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells

对 Perturb-seq 在分化人类多能干细胞中的应用进行基准测试和优化

Sivakumar, Sushama; Wang, Yihan; Goetsch, Sean C; Pandit, Vrushali; Wang, Lei; Zhao, Huan; Sundarrajan, Anjana; Armendariz, Daniel; Takeuchi, Chikara; Deng, Minnie; Nzima, Mpathi; Chen, Wei-Chen; Dederich, Ashley E; El Hayek, Lauretta; Gao, Taosha; Gogate, Ashlesha; Kaur, Kiran; Kim, Hyung Bum; McCoy, Melissa K; Niederstrasser, Hanspeter; Oura, Seiya; Pinzon-Arteaga, Carlos A; Sanghvi, Menaka; Schmitz, Daniel A; Yu, Leqian; Zhang, Yanfeng; Zhou, Qinbo; Kraus, W Lee; Xu, Lin; Wu, Jun; Posner, Bruce A; Chahrour, Maria H; Hon, Gary C; Munshi, Nikhil V

Synergistic and antagonistic drug interactions are prevalent but not conserved across acute myeloid leukemia cell lines

药物的协同和拮抗作用普遍存在,但并非在急性髓系白血病细胞系中都保守存在。

Kalkan, Fatma Neslihan; Yildiz, Muhammed Sadik; Wood, N Ezgi; Farid, Michael; McCoy, Melissa; Lin, Milo M; Zhang, Chengcheng; Posner, Bruce A; Chung, Stephen S; Toprak, Erdal

Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine.

通过活性位点半胱氨酸对 SARS-CoV-2 NiRAN 结构域进行共价抑制

Hernandez Genaro, Osinski Adam, Majumdar Abir, Eitson Jennifer L, Antczak Monika, Pawłowski Krzysztof, Niederstrasser Hanspeter, Servage Kelly A, Posner Bruce, Schoggins John W, Ready Joseph M, Tagliabracci Vincent S

Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na(+) Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening

通过表型筛选鉴定具有快速杀灭无性血液期疟原虫活性的α-氮杂环乙酰胺类恶性疟原虫钠泵(PfATP4)抑制剂

Casas, Arturo Jr; Imlay, Leah S; Thathy, Vandana; Fairhurst, Kate J; Lehane, Adele M; Lawong, Aloysus K; Deni, Ioanna; Striepen, Josefine; Lee, Seungheon; Kumar, Ashwani; Xing, Chao; Niederstrasser, Hanspeter; Posner, Bruce A; Laleu, Benoît; Charman, Susan A; Fidock, David A; Ready, Joseph M; Phillips, Margaret A

Contrasting interferon-mediated antiviral responses in human lung adenocarcinoma cells.

人类肺腺癌细胞中干扰素介导的抗病毒反应的对比

Esparza Matthew, El Zahed Sara S, Karakus Umut, Niederstrasser Hanspeter, Gao Boning, Batten Kimberly, Shay Jerry W, Posner Bruce, Hirsch Fred R, Girard Luc, Huang Lily Jun-Shen, Minna John, García-Sastre Adolfo, Fontoura Beatriz M A

A Computational Workflow for Structure-Guided Design of Potent and Selective Kinase Peptide Substrates.

基于结构导向的高效选择性激酶肽底物设计的计算工作流程

Yekeen Abeeb A, Meyer Cynthia J, McCoy Melissa, Posner Bruce, Westover Kenneth D

Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface.

某些偶氮化合物可通过与三聚体界面相互作用,在翻译后调节 HTRA1 的丰度和活性

Hulleman John D, Jeon Seungje, Bali Sofia, DiCesare Sophia M, Abbas Ali, Daniel Steffi, Ortega Antonio J, Collier Gracen E, Yang Julian, Bhattacharyaa Archishman, McCoy Melissa K, Joachimiak Lukasz A, Posner Bruce A

GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology

GSK3抑制剂可减少细胞外基质的生成,并预防与年龄相关的黄斑变性样病变。

DiCesare, Sophia M; Ortega, Antonio J; Collier, Gracen E; Daniel, Steffi; Thompson, Krista N; McCoy, Melissa K; Posner, Bruce A; Hulleman, John D