日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Comprehensive perturbation of transcription factors in human cardiomyocytes reveals the regulatory architecture of congenital heart disease

对人类心肌细胞中转录因子的全面扰动揭示了先天性心脏病的调控结构

Takeuchi, Chikara; Sivakumar, Sushama; Sundarrajan, Anjana; Wang, Yihan; Goetsch, Sean C; Zhao, Huan; Wang, Lei; Nzima, Mpathi; Deng, Minnie; Kulkarni, Kartik N; Xu, Lin; Wu, Jun; Posner, Bruce A; Chahrour, Maria H; Kraus, W Lee; Munshi, Nikhil V; Hon, Gary C

Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS).

通过高通量筛选 (HTS) 鉴定针对孤立性纤维瘤 (SFT) 的 BET 抑制剂 (BETi)。

Mondaza-Hernandez Jose L, Moura David S, Li Yi, Marti Jesus L, Gomez-Puertas Paulino, Nguyen John T, Wei Shuguang, Posner Bruce A, Meyer Clark A, Bleris Leonidas, Martin-Broto Javier, Hayenga Heather N

Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells

对 Perturb-seq 在分化人类多能干细胞中的应用进行基准测试和优化

Sivakumar, Sushama; Wang, Yihan; Goetsch, Sean C; Pandit, Vrushali; Wang, Lei; Zhao, Huan; Sundarrajan, Anjana; Armendariz, Daniel; Takeuchi, Chikara; Deng, Minnie; Nzima, Mpathi; Chen, Wei-Chen; Dederich, Ashley E; El Hayek, Lauretta; Gao, Taosha; Gogate, Ashlesha; Kaur, Kiran; Kim, Hyung Bum; McCoy, Melissa K; Niederstrasser, Hanspeter; Oura, Seiya; Pinzon-Arteaga, Carlos A; Sanghvi, Menaka; Schmitz, Daniel A; Yu, Leqian; Zhang, Yanfeng; Zhou, Qinbo; Kraus, W Lee; Xu, Lin; Wu, Jun; Posner, Bruce A; Chahrour, Maria H; Hon, Gary C; Munshi, Nikhil V

Synergistic and antagonistic drug interactions are prevalent but not conserved across acute myeloid leukemia cell lines

药物的协同和拮抗作用普遍存在,但并非在急性髓系白血病细胞系中都保守存在。

Kalkan, Fatma Neslihan; Yildiz, Muhammed Sadik; Wood, N Ezgi; Farid, Michael; McCoy, Melissa; Lin, Milo M; Zhang, Chengcheng; Posner, Bruce A; Chung, Stephen S; Toprak, Erdal

Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na(+) Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening

通过表型筛选鉴定具有快速杀灭无性血液期疟原虫活性的α-氮杂环乙酰胺类恶性疟原虫钠泵(PfATP4)抑制剂

Casas, Arturo Jr; Imlay, Leah S; Thathy, Vandana; Fairhurst, Kate J; Lehane, Adele M; Lawong, Aloysus K; Deni, Ioanna; Striepen, Josefine; Lee, Seungheon; Kumar, Ashwani; Xing, Chao; Niederstrasser, Hanspeter; Posner, Bruce A; Laleu, Benoît; Charman, Susan A; Fidock, David A; Ready, Joseph M; Phillips, Margaret A

Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na (+) pump ( Pf ATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening

通过表型筛选鉴定出具有快速杀灭无性血液期疟原虫活性的α-氮杂环乙酰胺类恶性疟原虫钠泵(Pf ATP4)抑制剂

Casas, Arturo; Imlay, Leah S; Thathy, Vandana; Fairhurst, Kate J; Lehane, Adele M; Lawong, Aloysus K; Deni, Ionna; Striepen, Josefine; Lee, Seungheon; Kumar, Ashwani; Xing, Chao; Niederstrasser, Hanspeter; Posner, Bruce A; Laleu, Benoît; Charman, Susan A; Fidock, David A; Ready, Joseph M; Phillips, Margaret A

Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface.

某些偶氮化合物可通过与三聚体界面相互作用,在翻译后调节 HTRA1 的丰度和活性

Hulleman John D, Jeon Seungje, Bali Sofia, DiCesare Sophia M, Abbas Ali, Daniel Steffi, Ortega Antonio J, Collier Gracen E, Yang Julian, Bhattacharyaa Archishman, McCoy Melissa K, Joachimiak Lukasz A, Posner Bruce A

A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells

一种能结合胆固醇的细菌毒素为鉴定一种特异性的Scap抑制剂提供了一种策略,该抑制剂可以阻断动物细胞中的脂质合成。

Xu, Shimeng; Smothers, Jared C; Rye, Daphne; Endapally, Shreya; Chen, Hong; Li, Shili; Liang, Guosheng; Kinnebrew, Maia; Rohatgi, Rajat; Posner, Bruce A; Radhakrishnan, Arun

GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology

GSK3抑制剂可减少细胞外基质的生成,并预防与年龄相关的黄斑变性样病变。

DiCesare, Sophia M; Ortega, Antonio J; Collier, Gracen E; Daniel, Steffi; Thompson, Krista N; McCoy, Melissa K; Posner, Bruce A; Hulleman, John D

Synthesis of the 5/5-spiroindimicin alkaloids: development of a general synthetic approach and biological investigations

5/5-螺吲哚生物碱的合成:通用合成方法的建立及生物学研究

Banerjee, Ankush; Brisco, Tiffany A; Ray, Sneha; Datta, Arani; Zhang, Xiaoyu; Zhang, Zhen; Busse, Alexander A; Niederstrasser, Hanspeter; Sumida, Krissty; Posner, Bruce A; Wetzel, Dawn M; Phillips, Margaret A; Smith, Myles W