Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy
隐孢子虫赖氨酰tRNA合成酶抑制剂阐明了溶解度和渗透性之间的相互作用,而这种相互作用是实现疗效所必需的。
期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.adm8631
Caldwell, Nicola; Peet, Caroline; Miller, Peter; Colon, Beatrice L; Taylor, Malcolm G; Cocco, Mattia; Dawson, Alice; Lukac, Iva; Teixeira, Jose E; Robinson, Lee; Frame, Laura; Seizova, Simona; Damerow, Sebastian; Tamaki, Fabio; Post, John; Riley, Jennifer; Mutter, Nicole; Hanna, Jack C; Ferguson, Liam; Hu, Xiao; Tinti, Michele; Forte, Barbara; Norcross, Neil R; Campbell, Peter S; Svensen, Nina; Caldwell, Flora C; Jansen, Chimed; Postis, Vincent; Read, Kevin D; Huston, Christopher D; Gilbert, Ian H; Baragaña, Beatriz; Pawlowic, Mattie C