日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia.

表观遗传改变促进缺氧条件下的转录和翻译程序。

Watt Kathleen, Dauber Bianca, Szkop Krzysztof J, Lee Laura, Jovanovic Predrag, Chen Shan, Palia Ranveer, Vassalakis Julia A, Cooper Tyler T, Papadopoli David, Masvidal Laìa, Jewer Michael, Tandoc Kristofferson, Plummer Hannah, Lajoie Gilles A, Topisirovic Ivan, Larsson Ola, Postovit Lynne-Marie

Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System

细胞外囊泡在人类造血系统中定义了离散的纳米级微环境

Grenier-Pleau, Isabelle J; Wells, Christopher J; Holmes, Samantha M; Hall, Christine; Vermeulen, Michael; de Villiers, Camille A; Penders, Jelle; Pedersen, Simon Vilms; Dick, Sarah A; Bonneil, Eric; Slobodyanyuk, Mykhaylo; Nagree, Murtaza S; Kaur, Jasleen; McNaughton, Amy J M; Beaulieu, Jamie; Stevens, Molly M; Xie, Stephanie Z; Rauh, Michael J; Postovit, Lynne-Marie; Knapp, David J H F; Reimand, Jüri; Tyryshkin, Kathrin; Thibault, Pierre; Craig, Andrew W; Rudan, John F; Mann, Steve; Chan, Edmond Y W; Abraham, Sheela A

Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition

多组学分析发现,肉豆蔻酰化抑制导致的氧化磷酸化是癌症的一种脆弱性因素。

Erwan Beauchamp,Jay M Gamma,Christopher R Cromwell,Eman W Moussa,Rony Pain,Morris A Kostiuk,Claudia Acevedo-Morantes,Aishwarya Iyer,Megan Yap,Krista M Vincent,Lynne M Postovit,Olivier Julien,Basil P Hubbard,John R Mackey,Luc G Berthiaume

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

MTOR 调节会诱导组蛋白甲基化的选择性扰动,从而影响 mTOR 抑制剂的抗增殖作用

HaEun Kim, Benjamin Lebeau, David Papadopoli, Predrag Jovanovic, Mariana Russo, Daina Avizonis, Masahiro Morita, Farzaneh Afzali, Josie Ursini-Siegel, Lynne-Marie Postovit, Michael Witcher, Ivan Topisirovic

Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer

血浆细胞外囊泡的靶向蛋白质组学揭示 MUC1 作为高级别浆液性卵巢癌早期检测的组合生物标志物

Tyler T Cooper, Dylan Z Dieters-Castator, Jiahui Liu, Gabrielle M Siegers, Desmond Pink, Lorena Veliz, John D Lewis, François Lagugné-Labarthet, Yangxin Fu, Helen Steed, Gilles A Lajoie, Lynne-Marie Postovit

Cancer-associated Fibroblast-specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis

癌相关成纤维细胞特异性表达基质细胞蛋白CCN1协调黑色素瘤转移中的新生血管形成和基质沉积

James Hutchenreuther # ,John Nguyen # ,Katherine Quesnel # ,Krista M Vincent # ,Louis Petitjean ,Sophia Bourgeois ,Mark Boyd ,George Bou-Gharios ,Lynne-Marie Postovit ,Andrew Leask

Wounding the stroma: Docetaxel's role in dormant breast cancer escape

损伤基质:多西他赛在休眠乳腺癌逃逸中的作用

Cooper, Tyler T; Postovit, Lynne-Marie

Cancer Plasticity: The Role of mRNA Translation

癌症可塑性:mRNA翻译的作用

Lee, Laura J; Papadopoli, David; Jewer, Michael; Del Rincon, Sonia; Topisirovic, Ivan; Lawrence, Mitchell G; Postovit, Lynne-Marie

Genome profiles of pathologist-defined cell clusters by multiregional LCM and G&T-seq in one triple-negative breast cancer patient

通过多区域 LCM 和 G&T-seq 对一名三阴性乳腺癌患者进行病理学家定义的细胞簇的基因组图谱分析

Zhongyi Zhu, Weiwei Wang, Feng Lin, Tracy Jordan, Guibo Li, Sveta Silverman, Si Qiu, Anil Abraham Joy, Chao Chen, Deanna L Hockley, Xi Zhang, Qing Zhou, Lynne M Postovit, Xiuqing Zhang, Yong Hou, John R Mackey, Bo Li, Gane Ka-Shu Wong

Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL

利用基因编码技术发现对形态发生素NODAL具有蛋白水解稳定性的双环抑制剂

Wong, Jeffrey Y-K; Mukherjee, Raja; Miao, Jiayuan; Bilyk, Olena; Triana, Vivian; Miskolzie, Mark; Henninot, Antoine; Dwyer, John J; Kharchenko, Serhii; Iampolska, Anna; Volochnyuk, Dmitriy M; Lin, Yu-Shan; Postovit, Lynne-Marie; Derda, Ratmir