日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity.

发现并表征了具有强大髓系激活和抗肿瘤活性的首创 LIV1-TLR7/8 免疫调节偶联物

Yamazoe Sayumi, Poudel Yam, Sega Emanuela, Mukhopadhyay Anandaroop, Ramakrishnan Radha, Ukairo Okechukwu, Liu Scot, Akter Rahima, Sadanala Keerthi, Que Kathryn, Cheng Qinqin, Kotapati Srikanth, Deshpande Madhura, Cox Matthew, Chourey Shishir, Gupta Anuradha, Kempson James, Pabbisetty Kumar, Kaspady Mahammed, Bhattasali Debabrata, Yip Shiuhang, Wu Dauh-Rurng, Pookot Deepa, Li Yvonne, Kozhich Alexander, Drexler Dieter, Carl Stephen, Deyanova Ekaterina, Smith Michael, Chan Henry, West Sean, Diong S J, Chang Aram, Florin Lore, Mathur Arvind, Strop Pavel, Zapf Christoph W, Law Deborah, Wilson Nicholas, Broz Miranda, Chekler Eugene P

Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach

基于结构的新型TLR7/8激动剂有效载荷设计,可实现免疫调节偶联物策略

Poudel, Yam B; Lo, Julian C; Norris, Derek J; Cox, Matthew; He, Liqi; Johnson, Walter L; A M Subbaiah, Murugaiah; Mondal, Santigopal; Thangavel, Soodamani; Subramani, Lakshumanan; Reddy, Maheswara; Jain, Suraksha; Weiss, Dahlia R; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Dhar, Payal; Li, Yvonne; Sega, Emanuela; Yamazoe, Sayumi; Gavai, Ashvinikumar V; Mathur, Arvind; Zapf, Christoph W; Chekler, Eugene P

Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells

将TLR7激动剂靶向递送至肿瘤微环境可通过激活肿瘤驻留髓系细胞增强肿瘤免疫力

Sega, Emanuela; Kotapati, Srikanth; Poudel, Yam B; Cheng, Qinqin; Sadanala, Keerthi; Schneider, Bridget; Chekler, Eugene P; Rao, Chetana; Gangwar, Sanjeev; Sproul, Tim; Law, Deborah; Broz, Miranda; Strop, Pavel; Yamazoe, Sayumi

Design and Characterization of Prodrugged Anti-CTLA-4 Antibodies

前药化抗CTLA-4抗体的设计与表征

Yamazoe, Sayumi; Huber, Mary; Kotapati, Srikanth; Akter, Rahima; Jashnani, Aarti; Deol, Suprit; Bee, Christine; Engelhart, John; Poudel, Yam B; Krystek, Stanley; Haugner, John; Srinivasan, Mohan; Rajpal, Arvind; Zhang, Yong; Strop, Pavel; Rao, Chetana

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology

发现新型TLR7激动剂作为全身性药物与抗PD-1抗体联合用于免疫肿瘤学

Poudel, Yam B; He, Liqi; Cox, Matthew; Zhang, Qian; Johnson, Walter L; Cong, Qiang; Cheng, Heng; Chowdari, Naidu S; Tarby, Christine; Donnell, Andrew F; Broekema, Matthais; O'Malley, Daniel P; Zhang, Yong; A M Subbaiah, Murugaiah; Kumar, Boda Vijay; Subramani, Lakshumanan; Wang, Bei; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Sandhu, Bhupindar; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Oderinde, Martins S; Murtaza, Anwar; Schieven, Gary L; Mathur, Arvind; Gavai, Ashvinikumar V; Vite, Gregory; Gangwar, Sanjeev

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology

鉴定和优化小分子吡唑并嘧啶类TLR7激动剂在免疫肿瘤学中的应用

He, Liqi; Zhang, Meng Yao; Cox, Matthew; Zhang, Qian; Donnell, Andrew F; Zhang, Yong; Tarby, Christine; Gill, Patrice; Subbaiah, Murugaiah A M; Ramar, Thangeswaran; Reddy, Maheswara; Puttapaka, Vijaya; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Murtaza, Anwar; Oderinde, Martins S; Schieven, Gary L; Mathur, Arvind; Gavai, Ashvinikumar V; Vite, Gregory; Gangwar, Sanjeev; Poudel, Yam B

Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs

二氢麦角酸和二氢麦角醇的全合成:一种适用于快速组装D环类似物的发散合成策略的开发

Lee, Kiyoun; Poudel, Yam B; Glinkerman, Christopher M; Boger, Dale L

Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1

脂溶性较低且合成更易获得的bryostatin 7的生物学特性与bryostatin 1非常相似。

Kedei, Noemi; Lewin, Nancy E; Géczy, Tamás; Selezneva, Julia; Braun, Derek C; Chen, Jinqiu; Herrmann, Michelle A; Heldman, Madeleine R; Lim, Langston; Mannan, Poonam; Garfield, Susan H; Poudel, Yam B; Cummins, Thomas J; Rudra, Arnab; Blumberg, Peter M; Keck, Gary E

Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

bryostatin 1 的 C8 二甲基基团对其独特生物活性模式的作用

Keck, Gary E; Poudel, Yam B; Rudra, Arnab; Stephens, Jeffrey C; Kedei, Noemi; Lewin, Nancy E; Blumberg, Peter M

Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1

C9-脱氧布里奥他汀1的分子建模、全合成和生物学评价

Keck, Gary E; Poudel, Yam B; Rudra, Arnab; Stephens, Jeffrey C; Kedei, Noemi; Lewin, Nancy E; Peach, Megan L; Blumberg, Peter M