日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP

利用 MultiSTEP 技术对分泌蛋白中的变异效应进行多重和多模态映射

Popp, Nicholas A; Powell, Rachel L; Wheelock, Melinda K; Holmes, Kristen J; Zapp, Brendan D; Sheldon, Kathryn M; Fletcher, Shelley N; Wu, Xiaoping; Fayer, Shawn; Rubin, Alan F; Lannert, Kerry W; Chang, Alexis T; Sheehan, John P; Johnsen, Jill M; Fowler, Douglas M

Editing stem cell genomes at scale to measure variant effects in diverse cell and genetic contexts

大规模编辑干细胞基因组,以测量不同细胞和遗传背景下的变异效应

Fayer, Shawn; Garge, Riddhiman K; Hopkins, Melissa; Friedman, Clayton E; McGee, Abby V; Rico, Joshua; Powell, Rachel L; McDermot, Evan; Smith, Nahum T; Pendyala, Sriram; Richardson, Marcy E; Smith, Erica D; Bowen, B Monica; Resnick, Rebecca; Gupta, Pankhuri; Stergachis, Andrew B; Gifford, Casey; Pinglay, Sudarshan; Yang, Kai-Chun; Fowler, Douglas M; Starita, Lea M

Multiplex, multimodal mapping of variant effects in secreted proteins

分泌蛋白变异效应的多重、多模态映射

Popp, Nicholas A; Powell, Rachel L; Wheelock, Melinda K; Holmes, Kristen J; Zapp, Brendan D; Sheldon, Kathryn M; Fletcher, Shelley N; Wu, Xiaoping; Fayer, Shawn; Rubin, Alan F; Lannert, Kerry W; Chang, Alexis T; Sheehan, John P; Johnsen, Jill M; Fowler, Douglas M

Functional evidence for G6PD variant classification from mutational scanning.

通过突变扫描获得G6PD变异分类的功能证据

Geck Renee C, Wheelock Melinda K, Powell Rachel L, Wang Ziyu R, Holmes Daniel L, Fayer Shawn, Boyle Gabriel E, Vandi Allyssa J, McGee Abby V, Amorosi Clara J, Moore Nick, Rubin Alan F, Fowler Douglas M, Dunham Maitreya J

Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects.

基于图像的汇总表型分析揭示了多维度的、疾病特异性的变异效应

Pendyala Sriram, Partington Katie, Bradley Nicholas, McEwen Abbye E, Straub Gwenneth, Kim Hyeon-Jin, Fayer Shawn, Holmes Daniel Lee, Sitko Katherine A, Vandi Allyssa J, Powell Rachel L, Friedman Clayton E, McDermot Evan, Kishore Nishka, Roth Frederick P, Rubin Alan F, Yang Kai-Chun, Starita Lea M, Noble William S, Fowler Douglas M