日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of cystathionine-β-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome.

胱硫醚β-合成酶的缺失导致氧化磷酸化水平升高,这是唐氏综合征中阿糖胞苷耐药性髓系白血病的一个弱点。

Thibodeau Jenna, Zhao Jianlei, Edwards Holly, Polin Lisa, Kushner Juiwanna, Dzinic Sijana H, White Kathryn, Hershberger Kian, Su Yongwei, Arroum Tasnim, Pham Lucynda, Pavelich Lauren, Awdish Raina, LaValley Jacob, Boucher Austin C, Chen Wei, Li Jing, Bao Xun, Hüttemann Maik, Back Jessica B, Allen Joshua E, Prabhu Varun V, Crispino John D, Taub Jeffrey W, Ge Yubin

TMET-26. Allosteric ClpP agonist ONC206 alters mitochondrial metabolism and stress response to elicit apoptosis in meningioma

TMET-26。变构ClpP激动剂ONC206通过改变线粒体代谢和应激反应诱导脑膜瘤细胞凋亡。

Mahawar, Usha; Davis, Deanna L; Kannan, Muthukumar; Suemitsu, John; Oltorik, Christopher D; Farooq, Faheem; Fulani, Raheema; Weintraub, Collin; Allegood, Jeremy; Wattenberg, Binks; Lee, Andrew K; Maranto, Cristina; Foster, Scott; Prabhu, Varun V; Allen, Joshua E

ONC206 demonstrates potent anti-tumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma

ONC206 显示出强大的抗肿瘤活性,是一种潜在的高危髓母细胞瘤新型治疗策略。

Tzaridis, Theophilos; Liu, Jingbo; Chien, Franklin Lee; Malhotra, Anshu; Zhu, Dan; Gershon, Isabella; Zhang, Hongying; Velazquez Vega, Jose E; Schniederjan, Matthew; Sposito, Teresa; Adams, Peter D; Allen, Joshua E; Prabhu, Varun V; Wechsler-Reya, Robert J; MacDonald, Tobey J

Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo

ONC201 和 TLY012 联合用药可在体外诱导选择性、协同性细胞凋亡,并显著延缓体内 PDAC 异种移植瘤的生长。

Jhaveri, Aakash V; Zhou, Lanlan; Ralff, Marie D; Lee, Young S; Navaraj, Arunasalam; Carneiro, Benedito A; Safran, Howard; Prabhu, Varun V; Ross, Eric A; Lee, Seulki; El-Deiry, Wafik S

Correction: Discovery and clinical introduction of first-in-class imipridone ONC201

更正:首创药物咪吡啶酮 ONC201 的发现和临床应用

Allen, Joshua E; Kline, C Leah B; Prabhu, Varun V; Wagner, Jessica; Ishizawa, Jo; Madhukar, Neel; Lev, Avital; Baumeister, Marie; Zhou, Lanlan; Lulla, Amriti; Stogniew, Martin; Schalop, Lee; Benes, Cyril; Kaufman, Howard L; Pottorf, Richard S; Nallaganchu, B Rao; Olson, Gary L; Al-Mulla, Fahd; Duvic, Madeleine; Wu, Gen Sheng; Dicker, David T; Talekar, Mala K; Lim, Bora; Elemento, Olivier; Oster, Wolfgang; Bertino, Joseph; Flaherty, Keith; Wang, Michael L; Borthakur, Gautam; Andreeff, Michael; Stein, Mark; El-Deiry, Wafik S

Biological activity of weekly ONC201 in adult recurrent glioblastoma patients.

ONC201每周一次治疗成人复发性胶质母细胞瘤患者的生物活性

Arrillaga-Romany Isabel, Odia Yazmin, Prabhu Varun V, Tarapore Rohinton S, Merdinger Krystal, Stogniew Martin, Oster Wolfgang, Allen Joshua E, Mehta Minesh, Batchelor Tracy T, Wen Patrick Y

Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration

每周口服给药的 DRD2 拮抗剂 ONC201 在晚期实体瘤患者中的安全性和增强的免疫刺激活性

Stein, Mark N; Malhotra, Jyoti; Tarapore, Rohinton S; Malhotra, Usha; Silk, Ann W; Chan, Nancy; Rodriguez, Lorna; Aisner, Joseph; Aiken, Robert D; Mayer, Tina; Haffty, Bruce G; Newman, Jenna H; Aspromonte, Salvatore M; Bommareddy, Praveen K; Estupinian, Ricardo; Chesson, Charles B; Sadimin, Evita T; Li, Shengguo; Medina, Daniel J; Saunders, Tracie; Frankel, Melissa; Kareddula, Aparna; Damare, Sherrie; Wesolowsky, Elayne; Gabel, Christian; El-Deiry, Wafik S; Prabhu, Varun V; Allen, Joshua E; Stogniew, Martin; Oster, Wolfgang; Bertino, Joseph R; Libutti, Steven K; Mehnert, Janice M; Zloza, Andrew

Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies

首创小分子药物伊米普利酮 ONC201 在血液系统恶性肿瘤中的单药及协同联合疗效

Prabhu, Varun V; Talekar, Mala K; Lulla, Amriti R; Kline, C Leah B; Zhou, Lanlan; Hall, Junior; Van den Heuvel, A Pieter J; Dicker, David T; Babar, Jawad; Grupp, Stephan A; Garnett, Mathew J; McDermott, Ultan; Benes, Cyril H; Pu, Jeffrey J; Claxton, David F; Khan, Nadia; Oster, Wolfgang; Allen, Joshua E; El-Deiry, Wafik S

ONC201 Demonstrates Antitumor Effects in Both Triple-Negative and Non-Triple-Negative Breast Cancers through TRAIL-Dependent and TRAIL-Independent Mechanisms

ONC201通过TRAIL依赖性和TRAIL非依赖性机制,在三阴性和非三阴性乳腺癌中均表现出抗肿瘤作用。

Ralff, Marie D; Kline, Christina L B; Küçükkase, Ozan C; Wagner, Jessica; Lim, Bora; Dicker, David T; Prabhu, Varun V; Oster, Wolfgang; El-Deiry, Wafik S

Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212.

对伊米普利酮家族(临床阶段抗癌小分子 ONC201 的类似物)的临床前评估显示,ONC212 具有强大的抗癌作用

Wagner Jessica, Kline Christina Leah, Ralff Marie D, Lev Avital, Lulla Amriti, Zhou Lanlan, Olson Gary L, Nallaganchu Bhaskara Rao, Benes Cyril H, Allen Joshua E, Prabhu Varun V, Stogniew Martin, Oster Wolfgang, El-Deiry Wafik S