日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

HMB-002: a monovalent antibody that elevates circulating VWF and FVIII levels for treatment of von Willebrand disease

HMB-002：一种单价抗体，可提高循环中VWF和FVIII水平，用于治疗血管性血友病。

期刊:Blood Advances
影响因子:7.1
doi:10.1182/bloodadvances.2025018516
Häger, Mattias; Zivkovic, Minka; Gandhi, Prafull S; Rasmussen, Caroline; Bonvoisin, Cécile; Harrison, Rane A; Poulsen, Emil; Huskens, Dana; Roest, Mark; Ferrara, Fortunato; Naretto, Anais; Renaud, Lionel; Olsen, Ole H; Eskesen, Nicolas O; Holten-Andersen, Lars; Malladi, Ruthvik; Rea, Catherine J; Sørensen, Benny; Urbanus, Rolf T; Østergaard, Henrik
VWF
发表日期：2026
文献求助 收藏

A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders

双特异性抗体方法可用于预防性治疗遗传性出血性疾病

期刊:Nature Cardiovascular Research
影响因子:9.4
doi:10.1038/s44161-023-00418-4
Prafull S Gandhi #, Minka Zivkovic #, Henrik Østergaard #, Amalie C Bonde, Torben Elm, Monika N Løvgreen, Gerd Schluckebier, Eva Johansson, Ole H Olsen, Eva H N Olsen, Ian-Arris de Bus, Karien Bloem, Oskar Alskär, Catherine J Rea, Søren E Bjørn, Roger E Schutgens, Benny Sørensen, Rolf T Urbanus, Joh
其它
发表日期：2024
文献求助 收藏

A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa

一种系统方法，用于评估胰蛋白酶样丝氨酸蛋白酶中表面暴露环对凝血因子 VIIa 中 170 环的作用

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/s41598-022-07620-7
Anders B Sorensen, Per Jr Greisen, Jesper J Madsen, Jacob Lund, Gorm Andersen, Pernille G Wulff-Larsen, Anette A Pedersen, Prafull S Gandhi, Michael T Overgaard, Henrik Østergaard, Ole H Olsen
信号转导
发表日期：2022
文献求助 收藏

A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice

一种模拟因子VIIIa的双特异性抗体Mim8，可减轻A型血友病小鼠在严重血管损伤后的出血症状。

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2020010331
Østergaard, Henrik; Lund, Jacob; Greisen, Per J; Kjellev, Stine; Henriksen, Anette; Lorenzen, Nikolai; Johansson, Eva; Røder, Gustav; Rasch, Morten G; Johnsen, Laust B; Egebjerg, Thomas; Lund, Søren; Rahbek-Nielsen, Henrik; Gandhi, Prafull S; Lamberth, Kasper; Loftager, Mette; Andersen, Lisbeth M; Bonde, Amalie C; Stavenuiter, Fabian; Madsen, Daniel E; Li, Xun; Holm, Thomas L; Ley, Carsten D; Thygesen, Peter; Zhu, Haisun; Zhou, Rong; Thorn, Karina; Yang, Zhiru; Hermit, Mette B; Bjelke, Jais R; Hansen, Bjarne G; Hilden, Ida
发表日期：2021
文献求助 收藏

Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa

以自己的方式击败组织因子：可溶性组织因子独立凝血因子 VIIa 的设计和特性

期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.RA119.009183
Anders B Sorensen, Inga Tuneew, L Anders Svensson, Egon Persson, Henrik Østergaard, Michael Toft Overgaard, Ole H Olsen, Prafull S Gandhi
信号转导
发表日期：2020
文献求助 收藏

Tissue Distribution and Receptor Activation by Somapacitan, a Long Acting Growth Hormone Derivative

长效生长激素衍生物 Somapacitan 的组织分布和受体激活

期刊:International Journal of Molecular Sciences
影响因子:0.7
doi:10.3390/ijms21041181
Maj Petersen, Prafull S Gandhi, Jens Buchardt, Tomas Alanentalo, Johannes Josef Fels, Nils Langeland Johansen, Peter Helding-Kvist, Knud Vad, Peter Thygesen
信号转导
WB
发表日期：2020
文献求助 收藏

Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures

通过晶体结构整体精修揭示凝血因子VIIa的变构作用

期刊:Biophysical Journal
影响因子:3.1
doi:10.1016/j.bpj.2019.03.024
Sorensen, Anders B; Madsen, Jesper J; Frimurer, Thomas M; Overgaard, Michael T; Gandhi, Prafull S; Persson, Egon; Olsen, Ole H
发表日期：2019
文献求助 收藏

Engineering of a membrane-triggered activity switch in coagulation factor VIIa

凝血因子VIIa中膜触发活性开关的工程设计

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1618713114
Nielsen, Anders L; Sorensen, Anders B; Holmberg, Heidi L; Gandhi, Prafull S; Karlsson, Johan; Buchardt, Jens; Lamberth, Kasper; Kjelgaard-Hansen, Mads; Ley, Carsten Dan; Sørensen, Brit B; Ruf, Wolfram; Olsen, Ole H; Østergaard, Henrik
发表日期：2017
文献求助 收藏

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity

凝血因子 VIIa-胰蛋白酶变体活性增强的分子基础为组织因子介导的凝血因子 VIIa 活性变构调节提供了见解

期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M115.698613
Anders B Sorensen, Jesper J Madsen, L Anders Svensson, Anette A Pedersen, Henrik Østergaard, Michael T Overgaard, Ole H Olsen, Prafull S Gandhi
信号转导
发表日期：2016
文献求助 收藏

Crystallographic and kinetic evidence of allostery in a trypsin-like protease

胰蛋白酶样蛋白酶变构作用的晶体学和动力学证据

期刊:Biochemistry
影响因子:3
doi:10.1021/bi200878c
Niu, Weiling; Chen, Zhiwei; Gandhi, Prafull S; Vogt, Austin D; Pozzi, Nicola; Pelc, Leslie A; Zapata, Fatima; Di Cera, Enrico
发表日期：2011
文献求助 收藏