Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q
通过靶向 mGluR5 阻止 C1Q 对突触的标记,逆转阿尔茨海默病小鼠模型中的突触丢失
期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.abi8593
Spurrier, Joshua; Nicholson, LaShae; Fang, Xiaotian T; Stoner, Austin J; Toyonaga, Takuya; Holden, Daniel; Siegert, Timothy R; Laird, William; Allnutt, Mary Alice; Chiasseu, Marius; Brody, A Harrison; Takahashi, Hideyuki; Nies, Sarah Helena; Pérez-Cañamás, Azucena; Sadasivam, Pragalath; Lee, Supum; Li, Songye; Zhang, Le; Huang, Yiyun H; Carson, Richard E; Cai, Zhengxin; Strittmatter, Stephen M