日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion

与暗色小胶质细胞和毒性脂质分泌相关的神经退行性细胞应激反应

Anna Flury,Leen Aljayousi,Hye-Jin Park,Mohammadparsa Khakpour,Jack Mechler,Siaresh Aziz,Jackson D McGrath,Pragney Deme,Colby Sandberg,Fernando González Ibáñez,Olivia Braniff,Thi Ngo,Simira Smith,Matthew Velez,Denice Moran Ramirez,Dvir Avnon-Klein,John W Murray,Jia Liu,Martin Parent,Susana Mingote,Norman J Haughey,Sebastian Werneburg,Marie-Ève Tremblay,Pinar Ayata

Insulin acts on astrocytes to shift their substrate preference to fatty acids.

胰岛素作用于星形胶质细胞,使其底物偏好转向脂肪酸

Taib Bouchra, Deme Pragney, Gupta Sujasha, Yoo Seung Wan, Khuder Saja S, Hoke Ahmet, Li Zhigang, Ahima Rexford S, Haughey Norman J

Discovery of new pyridine 3-carboxylic acid-based pharmacophores as dual anti-inflammatory and anti-hyperglycemic agents

发现新型吡啶-3-羧酸基药效团作为双重抗炎和降血糖药物

Ramakrishnan, K; Nachimuthu, Lenin; Rajan, Reshma; Premkumar, J; Mulay, Vallabh; Meenakshi, S; Narasimhulu, Chandrakala A; Deme, Pragney; Rajagopalan, Sanjay; Lalgudi, Ramanathan; Sivaramakrishna, Akella; Karthikeyan, S; Desikan, Rajagopal

PeakClimber: A software tool for the accurate quantification of complex HPLC chromatograms

PeakClimber:一款用于精确量化复杂高效液相色谱图的软件工具

Derrick, Joshua T; Deme, Pragney; Haughey, Norman J; Farber, Steven A; Ludington, William B

Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation

恢复多发性硬化症相关的肠道吲哚代谢物失衡可促进髓鞘再生并抑制神经炎症

Jank, Larissa; Singh, Saumitra S; Lee, Judy; Dhukhwa, Asmita; Siavoshi, Fatemeh; Joshi, Deepika; Minney, Veronica; Gupta, Kanak; Ghimire, Sudeep; Deme, Pragney; Schoeps, Vinicius A; Soman, Karthik; Ladakis, Dimitrios; Smith, Matthew; Borkowski, Kamil; Newman, John; Baranzini, Sergio E; Waubant, Emmanuelle L; Fitzgerald, Kathryn C; Mangalam, Ashutosh; Haughey, Norman; Kornberg, Michael; Chamling, Xitiz; Calabresi, Peter A; Bhargava, Pavan

Etomoxir repurposed as a promiscuous fatty acid mimetic chemoproteomic probe

乙莫克舍被重新用作混杂脂肪酸模拟化学蛋白质组学探针

Joseph Choi, Danielle M Smith, Ye Jin Lee, Danfeng Cai, Mohammad J Hossain, Tamara J O'Connor, Pragney Deme, Norman J Haughey, Susanna Scafidi, Ryan C Riddle, Michael J Wolfgang

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model

抑制 tau 诱导的 nSMase2 活性升高和神经酰胺对阿尔茨海默病小鼠模型具有治疗作用

Carolyn Tallon, Benjamin J Bell, Medhinee M Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G Thomas, Kristen R Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R Joe, Rana Rais, Norman J Haughey, Dimitrios Kapogiannis, Barbara S Slusher

Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer

关键调节因子 PNPLA8 驱动磷脂重编程诱导的三阴性乳腺癌增殖和迁移

Zheqiong Tan, Pragney Deme, Keerti Boyapati, Britt S R Claes, Annet A M Duivenvoorden, Ron M A Heeren, Caitlin M Tressler, Norman James Haughey, Kristine Glunde

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer's disease

抑制 tau 诱导的 nSMase2 活性升高和神经酰胺可治疗小鼠阿尔茨海默病

Carolyn Tallon, Benjamin J Bell, Medhinee M Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G Thomas, Kristen R Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R Joe, Rana Rais, Norman J Haughey, Dimitrios Kapogiannis, Barbara S Slusher

Oxysterol misbalance critically contributes to Wilson disease pathogenesis

氧固醇失衡是威尔逊病发病的关键因素

Som Dev, Abigael Muchenditsi, Aline Gottlieb, Pragney Deme, Sean Murphy, Kathleen L Gabrielson, Yixuan Dong, Robert Hughes, Norman J Haughey, James P Hamilton, Svetlana Lutsenko