日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion

与暗色小胶质细胞和毒性脂质分泌相关的神经退行性细胞应激反应

Anna Flury,Leen Aljayousi,Hye-Jin Park,Mohammadparsa Khakpour,Jack Mechler,Siaresh Aziz,Jackson D McGrath,Pragney Deme,Colby Sandberg,Fernando González Ibáñez,Olivia Braniff,Thi Ngo,Simira Smith,Matthew Velez,Denice Moran Ramirez,Dvir Avnon-Klein,John W Murray,Jia Liu,Martin Parent,Susana Mingote,Norman J Haughey,Sebastian Werneburg,Marie-Ève Tremblay,Pinar Ayata

Etomoxir repurposed as a promiscuous fatty acid mimetic chemoproteomic probe

乙莫克舍被重新用作混杂脂肪酸模拟化学蛋白质组学探针

Joseph Choi, Danielle M Smith, Ye Jin Lee, Danfeng Cai, Mohammad J Hossain, Tamara J O'Connor, Pragney Deme, Norman J Haughey, Susanna Scafidi, Ryan C Riddle, Michael J Wolfgang

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model

抑制 tau 诱导的 nSMase2 活性升高和神经酰胺对阿尔茨海默病小鼠模型具有治疗作用

Carolyn Tallon, Benjamin J Bell, Medhinee M Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G Thomas, Kristen R Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R Joe, Rana Rais, Norman J Haughey, Dimitrios Kapogiannis, Barbara S Slusher

Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer

关键调节因子 PNPLA8 驱动磷脂重编程诱导的三阴性乳腺癌增殖和迁移

Zheqiong Tan, Pragney Deme, Keerti Boyapati, Britt S R Claes, Annet A M Duivenvoorden, Ron M A Heeren, Caitlin M Tressler, Norman James Haughey, Kristine Glunde

Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound

抑制中性鞘磷脂酶 2 可损害 HIV-1 包膜形成,并显著延缓或消除病毒反弹

Seung-Wan Yoo, Abdul A Waheed, Pragney Deme, Sehmus Tohumeken, Rana Rais, Matthew D Smith, Catherine DeMarino, Peter A Calabresi, Fatah Kashanchi, Eric O Freed, Barbara S Slusher, Norman J Haughey

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer's disease

抑制 tau 诱导的 nSMase2 活性升高和神经酰胺可治疗小鼠阿尔茨海默病

Carolyn Tallon, Benjamin J Bell, Medhinee M Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G Thomas, Kristen R Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R Joe, Rana Rais, Norman J Haughey, Dimitrios Kapogiannis, Barbara S Slusher

Oxysterol misbalance critically contributes to Wilson disease pathogenesis

氧固醇失衡是威尔逊病发病的关键因素

Som Dev, Abigael Muchenditsi, Aline Gottlieb, Pragney Deme, Sean Murphy, Kathleen L Gabrielson, Yixuan Dong, Robert Hughes, Norman J Haughey, James P Hamilton, Svetlana Lutsenko

High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair

高脂饮食和短期不可预测的压力会增加长链神经酰胺,而不会增强行为绝望

Lubriel Sambolín-Escobales, Lizmarie Tirado-Castro, Cristina Suarez, Dariangelly Pacheco-Cruz, Wilfred Fonseca-Ferrer, Pragney Deme, Norman Haughey, Gladys Chompre, James T Porter

Immunometabolic Reprogramming in Response to HIV Infection Is Not Fully Normalized by Suppressive Antiretroviral Therapy

抑制性抗逆转录病毒疗法无法完全恢复艾滋病毒感染后的免疫代谢重编程

Pragney Deme, Leah H Rubin, Danyang Yu, Yanxun Xu, Gertrude Nakigozi, Noeline Nakasujja, Aggrey Anok, Alice Kisakye, Thomas C Quinn, Steven J Reynolds, Richard Mayanja, James Batte, Maria J Wawer, Ned C Sacktor, Deanna Saylor, Norman J Haughey

Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice

谷氨酰胺拮抗剂JHU083可改善EcoHIV感染小鼠的心理社会行为和睡眠缺陷

Benjamin J Bell ,Kristen R Hollinger ,Pragney Deme ,Shinji Sakamoto ,Yuto Hasegawa ,David Volsky ,Atsushi Kamiya ,Norman Haughey ,Xiaolei Zhu ,Barbara S Slusher