Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases
以动力学为靶标的鸟枪法合成策略,发现了针对致病性自由生活变形虫葡萄糖激酶的小分子抑制剂。
期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.3c00284
Kassu, Mintesinot; Parvatkar, Prakash T; Milanes, Jillian; Monaghan, Neil P; Kim, Chungsik; Dowgiallo, Matthew; Zhao, Yingzhao; Asakawa, Ami H; Huang, Lili; Wagner, Alicia; Miller, Brandon; Carter, Karissa; Barrett, Kayleigh F; Tillery, Logan M; Barrett, Lynn K; Phan, Isabelle Q; Subramanian, Sandhya; Myler, Peter J; Van Voorhis, Wesley C; Leahy, James W; Rice, Christopher A; Kyle, Dennis E; Morris, James; Manetsch, Roman