日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapid human oogonia-like cell specification via transcription factor-directed differentiation

通过转录因子指导的分化实现人类卵原细胞样细胞的快速分化

Merrick Pierson Smela ,Christian C Kramme ,Patrick R J Fortuna ,Bennett Wolf ,Shrey Goel ,Jessica Adams ,Carl Ma ,Sergiy Velychko ,Ursula Widocki ,Venkata Srikar Kavirayuni ,Tianlai Chen ,Sophia Vincoff ,Edward Dong ,Richie E Kohman ,Mutsumi Kobayashi ,Toshi Shioda ,George M Church ,Pranam Chatterjee

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

可编程蛋白质降解剂能够在体内和体外选择性敲低致病 β-catenin 亚群

Tianzheng Ye, Azmain Alamgir, Cara M Robertus, Darianna Colina, Connor Monticello, Thomas Connor Donahue, Lauren Hong, Sophia Vincoff, Shrey Goel, Peter Fekkes, Luis Miguel Camargo, Kieu Lam, James Heyes, David Putnam, Christopher A Alabi, Pranam Chatterjee, Matthew P DeLisa

Programmable Protein Stabilization with Language Model-Derived Peptide Guides

利用语言模型衍生的肽指南进行可编程蛋白质稳定

Lauren Hong, Tianzheng Ye, Tian Zi Wang, Divya Srijay, Lin Zhao, Rio Watson, Sophia Vincoff, Tianlai Chen, Kseniia Kholina, Shrey Goel, Matthew P DeLisa, Pranam Chatterjee

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

使用对比语言模型对构象多样的靶标进行肽结合剂的从头设计

Suhaas Bhat, Kalyan Palepu, Lauren Hong, Joey Mao, Tianzheng Ye, Rema Iyer, Lin Zhao, Tianlai Chen, Sophia Vincoff, Rio Watson, Tian Wang, Divya Srijay, Venkata Srikar Kavirayuni, Kseniia Kholina, Shrey Goel, Pranay Vure, Aniruddha J Desphande, Scott H Soderling, Matthew P DeLisa, Pranam Chatterjee

Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

通过转录因子过表达将人诱导多能干细胞定向分化为功能性卵巢颗粒样细胞

Merrick D Pierson Smela # ,Christian C Kramme # ,Patrick R J Fortuna ,Jessica L Adams ,Rui Su ,Edward Dong ,Mutsumi Kobayashi ,Garyk Brixi ,Venkata Srikar Kavirayuni ,Emma Tysinger ,Richie E Kohman ,Toshi Shioda ,Pranam Chatterjee ,George M Church

Femtomolar detection of SARS-CoV-2 via peptide beacons integrated on a miniaturized TIRF microscope

通过微型 TIRF 显微镜上集成的肽信标对 SARS-CoV-2 进行飞摩尔级检测

Soumya P Tripathy, Manvitha Ponnapati, Suhaas Bhat, Joseph Jacobson, Pranam Chatterjee

Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers

扩大保持生殖系特征、无需血清或饲养层的人类原始生殖细胞样细胞的均质培养

Mutsumi Kobayashi, Misato Kobayashi, Junko Odajima, Keiko Shioda, Young Sun Hwang, Kotaro Sasaki, Pranam Chatterjee, Christian Kramme, Richie E Kohman, George M Church, Amanda R Loehr, Robert S Weiss, Harald Jüppner, Joanna J Gell, Ching C Lau, Toshi Shioda

An integrated pipeline for mammalian genetic screening

哺乳动物基因筛选的集成流程

Christian Kramme, Alexandru M Plesa, Helen H Wang, Bennett Wolf, Merrick Pierson Smela, Xiaoge Guo, Richie E Kohman, Pranam Chatterjee, George M Church

MegaGate: A toxin-less gateway molecular cloning tool

MegaGate:无毒网关分子克隆工具

Christian Kramme, Alexandru M Plesa, Helen H Wang, Bennett Wolf, Merrick Pierson Smela, Xiaoge Guo, Richie E Kohman, Pranam Chatterjee, George M Church

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

PD-1 通过抑制糖酵解、促进脂肪分解和脂肪酸氧化来改变 T 细胞代谢重编程

Nikolaos Patsoukis, Kankana Bardhan, Pranam Chatterjee, Duygu Sari, Bianling Liu, Lauren N Bell, Edward D Karoly, Gordon J Freeman, Victoria Petkova, Pankaj Seth, Lequn Li, Vassiliki A Boussiotis