日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Camonsertib, an ATRi, in Combination with Low-Dose Gemcitabine in Solid Tumors with DNA Damage Response Aberrations: Preclinical and Phase Ib Results

Camonsertib(一种ATRi)联合低剂量吉西他滨治疗伴有DNA损伤反应异常的实体瘤:临床前和Ib期研究结果

Rosen, Ezra Y; Yap, Timothy A; Fontana, Elisa; Lee, Elizabeth K; Mahalingam, Devalingam; Højgaard, Martin; Mettu, Niharika B; Cote, Gregory M; Plummer, Ruth; Koehler, Maria; Ulanet, Danielle; Fei, Kezhen; Silverman, Ian M; Schonhoft, Joseph D; Rimkunas, Victoria; Bacque, Emeline S; Gomez, Gabriela; Fretland, Adrian J; Roulston, Anne; Li, Li; Baruah, Prasamit; Zimmermann, Michal; Yang, Julia; Carneiro, Benedito A; Lheureux, Stephanie

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

CCNE1 扩增与 PKMYT1 激酶抑制一起具有合成致死性

David Gallo #, Jordan T F Young #, Jimmy Fourtounis #, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jess

Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ

鉴定出一种口服生物利用度高的化合物RP-6685,该化合物可抑制Polθ的DNA聚合酶活性。

Monica Bubenik ,Pavel Mader ,Philippe Mochirian ,Fréderic Vallée ,Jillian Clark ,Jean-François Truchon ,Alexander L Perryman ,Victor Pau ,Igor Kurinov ,Karl E Zahn ,Marie-Eve Leclaire ,Robert Papp ,Marie-Claude Mathieu ,Martine Hamel ,Nicole M Duffy ,Claude Godbout ,Matias Casas-Selves ,Jean-Pierre Falgueyret ,Prasamit S Baruah ,Olivier Nicolas ,Rino Stocco ,Hugo Poirier ,Giovanni Martino ,Alexanne Bonneau Fortin ,Anne Roulston ,Amandine Chefson ,Stéphane Dorich ,Miguel St-Onge ,Purvish Patel ,Charles Pellerin ,Stéphane Ciblat ,Thomas Pinter ,Francis Barabé ,Majida El Bakkouri ,Paranjay Parikh ,Christian Gervais ,Agnel Sfeir ,Yael Mamane ,Stephen J Morris ,W Cameron Black ,Frank Sicheri ,Michel Gallant

Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer

单染色体扩增在结肠癌中既可作为转移抑制因子,也可作为转移促进因子。

Anand Vasudevan,Prasamit S Baruah,Joan C Smith,Zihua Wang,Nicole M Sayles,Peter Andrews,Jude Kendall,Justin Leu,Narendra Kumar Chunduri,Dan Levy,Michael Wigler,Zuzana Storchová,Jason M Sheltzer

Expression of human Bcl-xL (Ser49) and (Ser62) mutants in Caenorhabditis elegans causes germline defects and aneuploidy

在秀丽隐杆线虫中表达人类 Bcl-xL (Ser49) 和 (Ser62) 突变体会导致生殖细胞缺陷和非整倍体

Baruah, Prasamit Saurav; Beauchemin, Myriam; Parker, J Alexander; Bertrand, Richard

Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts

有丝分裂过程中 Bcl-xL (S49) 和 (S62) 的动态磷酸化/去磷酸化可防止正常人二倍体成纤维细胞的染色体不稳定和非整倍体形成

Baruah, Prasamit Saurav; Beauchemin, Myriam; Hébert, Josée; Bertrand, Richard

Effect of vitamin E (Tri E®) on antioxidant enzymes and DNA damage in rats following eight weeks exercise

维生素E(Tri E®)对大鼠八周运动后抗氧化酶和DNA损伤的影响

Abd Hamid, Noor Aini; Hasrul, Mohd A; Ruzanna, Rusdiah J; Ibrahim, Ibrahim A; Baruah, Prasamit S; Mazlan, Musalmah; Yusof, Yasmin Anum Mohd; Ngah, Wan Zurinah Wan