日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Neural basis for mutant ATAXIN-1 induced respiratory dysfunction in mouse models of spinocerebellar ataxia type 1

突变型共济失调1型小鼠模型中ATAXIN-1诱导呼吸功能障碍的神经基础

期刊:Neurobiology of Disease
影响因子:5.6
doi:10.1016/j.nbd.2026.107356
Soles, Alyssa; Grittner, Jessica; Douglas, Kaia; Yang, Praseuth; Duvick, Lisa; O'Callaghan, Brennon; Barnett, Ryan; Chau, Christine; Cosiquien, Roj; Rainwater, Orion; Serres, Shannah; Dougherty, Brendan; Orr, Harry T; Cvetanovic, Marija
发表日期：2026
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An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model

ATAXIN1 中多聚谷氨酰胺的扩增导致其功能丧失，从而加剧 EAE 小鼠模型中多发性硬化症的严重程度。

期刊:Journal of Neuroinflammation
影响因子:10.1
doi:10.1186/s12974-025-03450-2
Talukdar, Gourango; Duvick, Lisa; Yang, Praseuth; O'Callaghan, Brennon; Fuchs, Gavin J; Cvetanovic, Marija; Orr, Harry T
神经科学
AXIN1
多发性硬化症
发表日期：2025
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Membrane-associated estrogen receptor α prevents the amyloid β-induced suppression of GIRK channel activity in hippocampal neurons from female mice

膜结合雌激素受体α可阻止淀粉样蛋白β诱导的雌性小鼠海马神经元GIRK通道活性抑制。

期刊:Biology of Sex Differences
影响因子:5.1
doi:10.1186/s13293-025-00776-7
Luo, Haichang; Marron Fernandez de Velasco, Ezequiel; Kim, Jaeyoon; Yang, Praseuth; Mermelstein, Paul; Bonventre, Joseph V; Cooke, Paul S; Wickman, Kevin
信号转导
神经科学
免疫/内分泌
发表日期：2025
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Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntington's disease

脊髓小脑性共济失调1型小鼠纹状体病理：与亨廷顿病的比较研究

期刊:
影响因子:
doi:10.64898/2025.12.11.693749
Goel, Pragya; Yang, Praseuth; Duvick, Lisa; Rainwater, Orion; Serres, Shannah; O'Callaghan, Brennon; Gomez-Pastor, Rocio; Mehkary, Mustafa; Gall-Duncan, Terence; Langfelder, Peter; Yang, X William; Pearson, Christopher E; Rothwell, Patrick E; Orr, Harry T
神经科学
发表日期：2025
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Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease

绘制 SCA1 区域脆弱性图可揭示神经和骨骼肌对疾病的贡献

期刊:JCI Insight
影响因子:6.3
doi:10.1172/jci.insight.176057
Lisa Duvick, W Michael Southern, Kellie A Benzow, Zoe N Burch, Hillary P Handler, Jason S Mitchell, Hannah Kuivinen, Udaya Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie A Sheeler, Orion Rainwater, Shannah Serres, Erin B Lind, Tessa Nichols-Meade, Yun You, Brennon O'Callaghan, Huda Y Zoghbi, Marija
神经
发表日期：2024
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A Neural Basis for Mutant ATAXIN-1 Induced Respiratory Dysfunction in Mouse Models of Spinocerebellar Ataxia Type 1

突变型共济失调1型小鼠模型中ATAXIN-1诱导呼吸功能障碍的神经基础

期刊:
影响因子:
doi:10.1101/2024.08.20.608114
Soles, Alyssa; Grittner, Jessica; Douglas, Kaia; Yang, Praseuth; Barnett, Ryan; Chau, Christine; Cosiquien, Roj; Duvick, Lisa; Rainwater, Orion; Serres, Shannah; Orr, Harry; Dougherty, Brendan; Cvetanovic, Marija
Mouse
发表日期：2024
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Delineating regional vulnerability in the neurodegenerative disease SCA1 using a conditional mutant ATXN1 mouse

使用条件突变 ATXN1 小鼠描绘神经退行性疾病 SCA1 的区域脆弱性

期刊:
影响因子:
doi:10.1101/2023.02.08.527710
Lisa Duvick, W Michael Southern, Kellie Benzow, Zoe N Burch, Hillary P Handler, Jason S Mitchell, Hannah Kuivinen, Udaya Keerthy Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie Scheeler, Orion Rainwater, Shannah Serres, Erin Lind, Tessa Nichols-Meade, Brennon O'Callaghan, Huda Y Zoghbi, Marija Cveta
神经
Mouse
发表日期：2023
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Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice

胆囊收缩素 1 受体激活可恢复正常的 mTORC1 信号传导并对 SCA 小鼠的浦肯野细胞具有保护作用

期刊:Cell Reports
影响因子:7.5
doi:10.1016/j.celrep.2021.109831
Emily A L Wozniak, Zhao Chen, Sharan Paul, Praseuth Yang, Karla P Figueroa, Jill Friedrich, Tyler Tschumperlin, Michael Berken, Melissa Ingram, Christine Henzler, Stefan M Pulst, Harry T Orr
信号转导
其它细胞
WB
mTOR
发表日期：2021
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The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways

Ataxin-1 相互作用组揭示与多种破坏的核运输途径直接相关

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-020-17145-0
Sunyuan Zhang, Nicholas A Williamson, Lisa Duvick, Alexander Lee, Harry T Orr, Austin Korlin-Downs, Praseuth Yang, Yee-Foong Mok, David A Jans, Marie A Bogoyevitch
信号转导
Donkey
IgG
发表日期：2020
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Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment

反义寡核苷酸疗法抑制 Ataxin-1 表达：安全性评估

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.5
doi:10.1016/j.omtn.2020.07.030
Brennon O'Callaghan, Bente Hofstra, Hillary P Handler, Holly B Kordasiewicz, Tracy Cole, Lisa Duvick, Jillian Friedrich, Orion Rainwater, Praseuth Yang, Michael Benneyworth, Tessa Nichols-Meade, Wesley Heal, Rachel Ter Haar, Christine Henzler, Harry T Orr
信号转导
Donkey
IgG
发表日期：2020
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