日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence.

干预性靶向体细胞 CAG 扩增可能是一种快速改变疾病的治疗途径:临床前证据

Gall-Duncan Terence, Ko Sangyoon Y, Quick Isabelle K, Khan Mahreen, Feng Kristie, Kelley Chase P, Coleman Annabelle, Touze Alexiane, Tang Shuqian, Mehkary Mustafa, Yokoi Katsuyuki, Herrington Casey R, You Justin, Lambie Scott C, Prasolava Tanya K, Panigrahi Gagan B, Park Jeehye, Nakatani Kazuhiko, Byrne Lauren M, Wang Peixiang, Schneekloth John S Jr, Nakamori Masayuki, Frankland Paul W, Wang Eric T, Pearson Christopher E

C9orf72 expansion creates the unstable folate-sensitive fragile site FRA9A

C9orf72 扩增导致不稳定的叶酸敏感脆性位点 FRA9A 的形成。

Mirceta, Mila; Schmidt, Monika H M; Shum, Natalie; Prasolava, Tanya K; Meikle, Bryanna; Lanni, Stella; Mohiuddin, Mohiuddin; Mckeever, Paul M; Zhang, Ming; Liang, Minggao; van der Werf, Ilse; Scheers, Stefaan; Dion, Patrick A; Wang, Peixiang; Wilson, Michael D; Abell, Theresa; Philips, Elliot A; Sznajder, Łukasz J; Swanson, Maurice S; Mehkary, Mustafa; Khan, Mahreen; Yokoi, Katsuyuki; Jung, Christine; de Jong, Pieter J; Freudenreich, Catherine H; McGoldrick, Philip; Yuen, Ryan K C; Abrahão, Agessandro; Keith, Julia; Zinman, Lorne; Robertson, Janice; Rogaeva, Ekaterina; Rouleau, Guy A; Kooy, R Frank; Pearson, Christopher E

C9orf72 repeat expansion creates the unstable folate-sensitive fragile site FRA9A

C9orf72重复序列扩增导致不稳定的叶酸敏感脆性位点FRA9A的形成。

Mirceta, Mila; Schmidt, Monika H M; Shum, Natalie; Prasolava, Tanya K; Meikle, Bryanna; Lanni, Stella; Mohiuddin, Mohiuddin; McKeever, Paul M; Zhang, Ming; Liang, Minggao; van der Werf, Ilse; Scheers, Stefaan; Dion, Patrick A; Wang, Peixiang; Wilson, Michael D; Abell, Theresa; Philips, Elliot A; Sznajder, Łukasz J; Swanson, Maurice S; Mehkary, Mustafa; Khan, Mahreen; Yokoi, Katsuyuki; Jung, Christine; de Jong, Pieter J; Freudenreich, Catherine H; McGoldrick, Philip; Yuen, Ryan K C; Abrahão, Agessandro; Keith, Julia; Zinman, Lorne; Robertson, Janice; Rogaeva, Ekaterina; Rouleau, Guy A; Kooy, R Frank; Pearson, Christopher E

Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability

经典和替代 RPA 在疾病相关串联 CAG 重复不稳定性中的拮抗作用

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A Fischer, Kyota Fujita, Amit L Deshmukh, Rachel J Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E Leib, Ran Chen, Hikari Tanaka, Amanda G Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stell

Genome-wide detection of tandem DNA repeats that are expanded in autism

全基因组检测自闭症中扩增的串联DNA重复序列

Trost, Brett; Engchuan, Worrawat; Nguyen, Charlotte M; Thiruvahindrapuram, Bhooma; Dolzhenko, Egor; Backstrom, Ian; Mirceta, Mila; Mojarad, Bahareh A; Yin, Yue; Dov, Alona; Chandrakumar, Induja; Prasolava, Tanya; Shum, Natalie; Hamdan, Omar; Pellecchia, Giovanna; Howe, Jennifer L; Whitney, Joseph; Klee, Eric W; Baheti, Saurabh; Amaral, David G; Anagnostou, Evdokia; Elsabbagh, Mayada; Fernandez, Bridget A; Hoang, Ny; Lewis, M E Suzanne; Liu, Xudong; Sjaarda, Calvin; Smith, Isabel M; Szatmari, Peter; Zwaigenbaum, Lonnie; Glazer, David; Hartley, Dean; Stewart, A Keith; Eberle, Michael A; Sato, Nozomu; Pearson, Christopher E; Scherer, Stephen W; Yuen, Ryan K C

A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo

滑脱的CAG DNA结合小分子在体内诱导三核苷酸重复收缩

Masayuki Nakamori #, Gagan B Panigrahi #, Stella Lanni #, Terence Gall-Duncan, Hideki Hayakawa, Hana Tanaka, Jennifer Luo, Takahiro Otabe, Jinxing Li, Akihiro Sakata, Marie-Christine Caron, Niraj Joshi, Tanya Prasolava, Karen Chiang, Jean-Yves Masson, Marc S Wold, Xiaoxiao Wang, Marietta Y W T Lee, 

Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts

巨噬细胞中 SIRPα 信号的破坏会消除异种移植中的人类急性髓系白血病干细胞

Alexandre P A Theocharides, Liqing Jin, Po-Yan Cheng, Tatiana K Prasolava, Andrei V Malko, Jenny M Ho, Armando G Poeppl, Nico van Rooijen, Mark D Minden, Jayne S Danska, John E Dick, Jean C Y Wang